| Full name: thioredoxin related transmembrane protein 2 | Alias Symbol: PDIA12 | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 51075 | HGNC ID: HGNC:30739 | Ensembl Gene: ENSG00000213593 | OMIM ID: 616715 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TMX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMX2 | 51075 | 201175_at | 0.3450 | 0.1866 | |
| GSE20347 | TMX2 | 51075 | 201175_at | 0.4316 | 0.0158 | |
| GSE23400 | TMX2 | 51075 | 201175_at | 0.5633 | 0.0000 | |
| GSE26886 | TMX2 | 51075 | 201175_at | -0.0254 | 0.9270 | |
| GSE29001 | TMX2 | 51075 | 201175_at | 0.2046 | 0.6080 | |
| GSE38129 | TMX2 | 51075 | 201175_at | 0.4681 | 0.0002 | |
| GSE45670 | TMX2 | 51075 | 201175_at | 0.5377 | 0.0010 | |
| GSE53622 | TMX2 | 51075 | 20410 | 0.0818 | 0.1918 | |
| GSE53624 | TMX2 | 51075 | 20410 | 0.4816 | 0.0000 | |
| GSE63941 | TMX2 | 51075 | 201175_at | 0.6038 | 0.1780 | |
| GSE77861 | TMX2 | 51075 | 201175_at | 0.5353 | 0.0558 | |
| GSE97050 | TMX2 | 51075 | A_24_P152635 | -0.0572 | 0.8160 | |
| SRP007169 | TMX2 | 51075 | RNAseq | 0.6625 | 0.1111 | |
| SRP008496 | TMX2 | 51075 | RNAseq | 0.7425 | 0.0062 | |
| SRP064894 | TMX2 | 51075 | RNAseq | 0.1804 | 0.2239 | |
| SRP133303 | TMX2 | 51075 | RNAseq | 0.2303 | 0.1646 | |
| SRP159526 | TMX2 | 51075 | RNAseq | 0.4281 | 0.0362 | |
| SRP193095 | TMX2 | 51075 | RNAseq | 0.0264 | 0.8126 | |
| SRP219564 | TMX2 | 51075 | RNAseq | 0.1337 | 0.6106 | |
| TCGA | TMX2 | 51075 | RNAseq | 0.0138 | 0.7740 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMX2 | 51075 | 2 | 3 | 25 | |
| GSE20123 | TMX2 | 51075 | 2 | 3 | 25 | |
| GSE43470 | TMX2 | 51075 | 1 | 5 | 37 | |
| GSE46452 | TMX2 | 51075 | 9 | 4 | 46 | |
| GSE47630 | TMX2 | 51075 | 3 | 8 | 29 | |
| GSE54993 | TMX2 | 51075 | 3 | 0 | 67 | |
| GSE54994 | TMX2 | 51075 | 5 | 6 | 42 | |
| GSE60625 | TMX2 | 51075 | 0 | 3 | 8 | |
| GSE74703 | TMX2 | 51075 | 1 | 3 | 32 | |
| GSE74704 | TMX2 | 51075 | 2 | 3 | 15 | |
| TCGA | TMX2 | 51075 | 14 | 10 | 72 |
Total number of gains: 42; Total number of losses: 48; Total Number of normals: 398.
Somatic mutations of TMX2:
Generating mutation plots.
Highly correlated genes for TMX2:
Showing top 20/270 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMX2 | SDCCAG8 | 0.712775 | 3 | 0 | 3 |
| TMX2 | PRR15 | 0.711823 | 3 | 0 | 3 |
| TMX2 | ERC2 | 0.708357 | 3 | 0 | 3 |
| TMX2 | FEN1 | 0.703517 | 8 | 0 | 7 |
| TMX2 | TMEM182 | 0.701942 | 6 | 0 | 6 |
| TMX2 | RRM2 | 0.681306 | 6 | 0 | 6 |
| TMX2 | TSR1 | 0.68026 | 3 | 0 | 3 |
| TMX2 | KLRG2 | 0.668336 | 4 | 0 | 3 |
| TMX2 | POC1A | 0.666438 | 5 | 0 | 4 |
| TMX2 | ARHGAP21 | 0.665304 | 3 | 0 | 3 |
| TMX2 | ZBTB24 | 0.657533 | 4 | 0 | 3 |
| TMX2 | RNF215 | 0.652959 | 4 | 0 | 3 |
| TMX2 | CLPB | 0.652738 | 8 | 0 | 7 |
| TMX2 | KIF4A | 0.65049 | 9 | 0 | 8 |
| TMX2 | RHEBL1 | 0.649119 | 3 | 0 | 3 |
| TMX2 | IGSF9 | 0.648922 | 3 | 0 | 3 |
| TMX2 | SLC35G1 | 0.646563 | 4 | 0 | 3 |
| TMX2 | DCPS | 0.642119 | 6 | 0 | 4 |
| TMX2 | EMC8 | 0.641713 | 10 | 0 | 10 |
| TMX2 | CDCA5 | 0.638003 | 8 | 0 | 6 |
For details and further investigation, click here
