| Full name: flap structure-specific endonuclease 1 | Alias Symbol: FEN-1|MF1 | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 2237 | HGNC ID: HGNC:3650 | Ensembl Gene: ENSG00000168496 | OMIM ID: 600393 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FEN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FEN1 | 2237 | 204767_s_at | 0.9771 | 0.0403 | |
| GSE20347 | FEN1 | 2237 | 204767_s_at | 1.4760 | 0.0000 | |
| GSE23400 | FEN1 | 2237 | 204767_s_at | 1.2065 | 0.0000 | |
| GSE26886 | FEN1 | 2237 | 204767_s_at | 0.7845 | 0.0037 | |
| GSE29001 | FEN1 | 2237 | 204767_s_at | 1.0877 | 0.0004 | |
| GSE38129 | FEN1 | 2237 | 204767_s_at | 1.6364 | 0.0000 | |
| GSE45670 | FEN1 | 2237 | 204767_s_at | 1.2423 | 0.0000 | |
| GSE63941 | FEN1 | 2237 | 204767_s_at | 1.5780 | 0.0171 | |
| GSE77861 | FEN1 | 2237 | 204767_s_at | 1.1782 | 0.0003 | |
| GSE97050 | FEN1 | 2237 | A_24_P84898 | 0.7787 | 0.1377 | |
| SRP007169 | FEN1 | 2237 | RNAseq | 1.7962 | 0.0000 | |
| SRP008496 | FEN1 | 2237 | RNAseq | 1.6035 | 0.0000 | |
| SRP064894 | FEN1 | 2237 | RNAseq | 1.2337 | 0.0000 | |
| SRP133303 | FEN1 | 2237 | RNAseq | 1.4037 | 0.0000 | |
| SRP159526 | FEN1 | 2237 | RNAseq | 1.4921 | 0.0000 | |
| SRP193095 | FEN1 | 2237 | RNAseq | 0.9762 | 0.0000 | |
| SRP219564 | FEN1 | 2237 | RNAseq | 1.7402 | 0.0008 | |
| TCGA | FEN1 | 2237 | RNAseq | 0.5926 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by FEN1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FEN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FEN1 | 2237 | 5 | 5 | 20 | |
| GSE20123 | FEN1 | 2237 | 5 | 5 | 20 | |
| GSE43470 | FEN1 | 2237 | 2 | 6 | 35 | |
| GSE46452 | FEN1 | 2237 | 8 | 4 | 47 | |
| GSE47630 | FEN1 | 2237 | 3 | 7 | 30 | |
| GSE54993 | FEN1 | 2237 | 3 | 0 | 67 | |
| GSE54994 | FEN1 | 2237 | 4 | 8 | 41 | |
| GSE60625 | FEN1 | 2237 | 0 | 3 | 8 | |
| GSE74703 | FEN1 | 2237 | 2 | 3 | 31 | |
| GSE74704 | FEN1 | 2237 | 4 | 3 | 13 | |
| TCGA | FEN1 | 2237 | 14 | 10 | 72 |
Total number of gains: 50; Total number of losses: 54; Total Number of normals: 384.
Somatic mutations of FEN1:
Generating mutation plots.
Highly correlated genes for FEN1:
Showing top 20/1024 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FEN1 | CDCA5 | 0.86585 | 7 | 0 | 7 |
| FEN1 | CDC6 | 0.843147 | 10 | 0 | 10 |
| FEN1 | KIF18B | 0.841675 | 10 | 0 | 10 |
| FEN1 | MTFR2 | 0.838197 | 5 | 0 | 5 |
| FEN1 | RAD51 | 0.823272 | 10 | 0 | 10 |
| FEN1 | GINS1 | 0.822024 | 9 | 0 | 9 |
| FEN1 | FOXM1 | 0.8177 | 11 | 0 | 11 |
| FEN1 | KIF14 | 0.814777 | 10 | 0 | 10 |
| FEN1 | MCM2 | 0.810281 | 11 | 0 | 11 |
| FEN1 | KIF4A | 0.809986 | 11 | 0 | 10 |
| FEN1 | DTL | 0.809769 | 10 | 0 | 9 |
| FEN1 | GINS2 | 0.804717 | 11 | 0 | 10 |
| FEN1 | BUB1B | 0.804511 | 11 | 0 | 10 |
| FEN1 | RAB3IP | 0.803182 | 3 | 0 | 3 |
| FEN1 | RFT1 | 0.801178 | 3 | 0 | 3 |
| FEN1 | CBX3 | 0.799674 | 9 | 0 | 9 |
| FEN1 | ORC6 | 0.799153 | 10 | 0 | 10 |
| FEN1 | CEP55 | 0.79538 | 10 | 0 | 9 |
| FEN1 | CHEK1 | 0.79439 | 9 | 0 | 9 |
| FEN1 | TIMELESS | 0.792309 | 10 | 0 | 10 |
For details and further investigation, click here
