POC1A

 

Full name: POC1 centriolar protein A Alias Symbol: DKFZP434C245
Type: protein-coding gene Cytoband: 3p21.2
Entrez ID: 25886 HGNC ID: HGNC:24488 Ensembl Gene: ENSG00000164087 OMIM ID: 614783
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of POC1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POC1A 25886 226355_at 0.5461 0.1963
GSE26886 POC1A 25886 226355_at 0.0817 0.8034
GSE45670 POC1A 25886 226355_at 0.6118 0.0000
GSE53622 POC1A 25886 2636 0.5888 0.0000
GSE53624 POC1A 25886 2636 1.0196 0.0000
GSE63941 POC1A 25886 226355_at 0.8809 0.0166
GSE77861 POC1A 25886 226355_at 0.0828 0.7303
GSE97050 POC1A 25886 A_23_P212284 0.4272 0.1566
SRP007169 POC1A 25886 RNAseq 0.9868 0.0955
SRP008496 POC1A 25886 RNAseq 0.2277 0.6004
SRP064894 POC1A 25886 RNAseq 1.2904 0.0000
SRP133303 POC1A 25886 RNAseq 1.1964 0.0001
SRP159526 POC1A 25886 RNAseq 0.5440 0.0861
SRP193095 POC1A 25886 RNAseq 0.4633 0.0003
SRP219564 POC1A 25886 RNAseq 0.6111 0.2392
TCGA POC1A 25886 RNAseq 0.7228 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by POC1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POC1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POC1A 25886 0 18 12
GSE20123 POC1A 25886 0 19 11
GSE43470 POC1A 25886 0 18 25
GSE46452 POC1A 25886 2 17 40
GSE47630 POC1A 25886 1 24 15
GSE54993 POC1A 25886 6 2 62
GSE54994 POC1A 25886 0 34 19
GSE60625 POC1A 25886 5 0 6
GSE74703 POC1A 25886 0 14 22
GSE74704 POC1A 25886 0 12 8
TCGA POC1A 25886 0 78 18

Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.  

 

Somatic mutations of POC1A:

 

Generating mutation plots.

 

Highly correlated genes for POC1A:

 

Showing top 20/432 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POC1ABAX0.803111303
POC1ACDCA80.80049707
POC1AHOXC90.784876303
POC1ARAD510.769873807
POC1AMELK0.769729707
POC1ACDC200.766037808
POC1AC7orf260.76489303
POC1AZWINT0.760035707
POC1AOIP50.759587505
POC1ACHEK10.759336606
POC1AMKI670.758047606
POC1ACDK10.755326606
POC1ABUB1B0.751189505
POC1AMAD2L10.750937606
POC1AZNF6390.744894303
POC1AGINS20.744072707
POC1AERCC6L0.740824605
POC1ACDCA50.739449807
POC1ADDIAS0.738876606
POC1AUHRF10.737845606

For details and further investigation, click here