| Full name: Rho GTPase activating protein 21 | Alias Symbol: KIAA1424|ARHGAP10 | ||
| Type: protein-coding gene | Cytoband: 10p12.1 | ||
| Entrez ID: 57584 | HGNC ID: HGNC:23725 | Ensembl Gene: ENSG00000107863 | OMIM ID: 609870 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ARHGAP21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGAP21 | 57584 | 224764_at | 0.4027 | 0.3411 | |
| GSE26886 | ARHGAP21 | 57584 | 224764_at | 1.4143 | 0.0000 | |
| GSE45670 | ARHGAP21 | 57584 | 224764_at | 0.2851 | 0.2824 | |
| GSE53622 | ARHGAP21 | 57584 | 58256 | 0.4533 | 0.0000 | |
| GSE53624 | ARHGAP21 | 57584 | 58256 | 0.6505 | 0.0000 | |
| GSE63941 | ARHGAP21 | 57584 | 224764_at | -0.6047 | 0.1810 | |
| GSE77861 | ARHGAP21 | 57584 | 224764_at | 0.2749 | 0.4596 | |
| GSE97050 | ARHGAP21 | 57584 | A_33_P3319406 | 0.2562 | 0.3054 | |
| SRP007169 | ARHGAP21 | 57584 | RNAseq | 0.8750 | 0.0062 | |
| SRP008496 | ARHGAP21 | 57584 | RNAseq | 0.9158 | 0.0001 | |
| SRP064894 | ARHGAP21 | 57584 | RNAseq | 0.4535 | 0.0673 | |
| SRP133303 | ARHGAP21 | 57584 | RNAseq | 0.6075 | 0.0000 | |
| SRP159526 | ARHGAP21 | 57584 | RNAseq | 0.1305 | 0.6356 | |
| SRP193095 | ARHGAP21 | 57584 | RNAseq | 0.4085 | 0.0471 | |
| SRP219564 | ARHGAP21 | 57584 | RNAseq | 0.1403 | 0.5949 | |
| TCGA | ARHGAP21 | 57584 | RNAseq | -0.1073 | 0.0778 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ARHGAP21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGAP21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGAP21 | 57584 | 5 | 7 | 18 | |
| GSE20123 | ARHGAP21 | 57584 | 5 | 6 | 19 | |
| GSE43470 | ARHGAP21 | 57584 | 4 | 4 | 35 | |
| GSE46452 | ARHGAP21 | 57584 | 1 | 14 | 44 | |
| GSE47630 | ARHGAP21 | 57584 | 5 | 15 | 20 | |
| GSE54993 | ARHGAP21 | 57584 | 9 | 0 | 61 | |
| GSE54994 | ARHGAP21 | 57584 | 3 | 9 | 41 | |
| GSE60625 | ARHGAP21 | 57584 | 0 | 0 | 11 | |
| GSE74703 | ARHGAP21 | 57584 | 3 | 2 | 31 | |
| GSE74704 | ARHGAP21 | 57584 | 0 | 5 | 15 | |
| TCGA | ARHGAP21 | 57584 | 18 | 25 | 53 |
Total number of gains: 53; Total number of losses: 87; Total Number of normals: 348.
Somatic mutations of ARHGAP21:
Generating mutation plots.
Highly correlated genes for ARHGAP21:
Showing top 20/251 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGAP21 | PGP | 0.79709 | 3 | 0 | 3 |
| ARHGAP21 | CUTC | 0.761755 | 3 | 0 | 3 |
| ARHGAP21 | SHARPIN | 0.746898 | 3 | 0 | 3 |
| ARHGAP21 | C19orf53 | 0.746141 | 3 | 0 | 3 |
| ARHGAP21 | PRMT3 | 0.741861 | 3 | 0 | 3 |
| ARHGAP21 | TRAIP | 0.741299 | 3 | 0 | 3 |
| ARHGAP21 | DHX34 | 0.737617 | 3 | 0 | 3 |
| ARHGAP21 | SPATA2L | 0.713405 | 4 | 0 | 4 |
| ARHGAP21 | CARD8 | 0.704421 | 3 | 0 | 3 |
| ARHGAP21 | HOXC9 | 0.704271 | 4 | 0 | 3 |
| ARHGAP21 | OSBPL11 | 0.70055 | 3 | 0 | 3 |
| ARHGAP21 | BFAR | 0.6949 | 4 | 0 | 4 |
| ARHGAP21 | RNF216 | 0.686304 | 3 | 0 | 3 |
| ARHGAP21 | ZNF639 | 0.683459 | 4 | 0 | 3 |
| ARHGAP21 | ZNF77 | 0.68067 | 3 | 0 | 3 |
| ARHGAP21 | PPIH | 0.676608 | 4 | 0 | 3 |
| ARHGAP21 | SNAI2 | 0.67639 | 6 | 0 | 5 |
| ARHGAP21 | WDR91 | 0.671769 | 3 | 0 | 3 |
| ARHGAP21 | LAMA3 | 0.670051 | 6 | 0 | 5 |
| ARHGAP21 | TMX2 | 0.665304 | 3 | 0 | 3 |
For details and further investigation, click here
