RRM2

 

Full name: ribonucleotide reductase regulatory subunit M2 Alias Symbol: 
Type: protein-coding gene Cytoband: 2p25.1
Entrez ID: 6241 HGNC ID: HGNC:10452 Ensembl Gene: ENSG00000171848 OMIM ID: 180390
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RRM2 involved pathways:

KEGG pathway Description View
hsa04115p53 signaling pathway

 

Expression of RRM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RRM2 6241 201890_at 1.0091 0.2657
GSE20347 RRM2 6241 201890_at 1.4000 0.0000
GSE23400 RRM2 6241 209773_s_at 1.3123 0.0000
GSE26886 RRM2 6241 201890_at -0.1922 0.7196
GSE29001 RRM2 6241 201890_at 1.3199 0.0008
GSE38129 RRM2 6241 209773_s_at 1.7254 0.0000
GSE45670 RRM2 6241 209773_s_at 1.4099 0.0000
GSE53622 RRM2 6241 86019 1.2659 0.0000
GSE53624 RRM2 6241 86019 1.0737 0.0000
GSE63941 RRM2 6241 209773_s_at 2.5750 0.0055
GSE77861 RRM2 6241 209773_s_at 0.3699 0.3047
GSE97050 RRM2 6241 A_24_P225616 0.4350 0.2049
SRP007169 RRM2 6241 RNAseq 1.9993 0.0004
SRP008496 RRM2 6241 RNAseq 1.7866 0.0000
SRP064894 RRM2 6241 RNAseq 1.2574 0.0002
SRP133303 RRM2 6241 RNAseq 1.4345 0.0000
SRP159526 RRM2 6241 RNAseq 1.2303 0.0002
SRP193095 RRM2 6241 RNAseq 0.8030 0.0000
SRP219564 RRM2 6241 RNAseq 1.3684 0.0671
TCGA RRM2 6241 RNAseq 1.0332 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by RRM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RRM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RRM2 6241 11 2 17
GSE20123 RRM2 6241 11 2 17
GSE43470 RRM2 6241 4 1 38
GSE46452 RRM2 6241 3 4 52
GSE47630 RRM2 6241 7 0 33
GSE54993 RRM2 6241 0 7 63
GSE54994 RRM2 6241 11 0 42
GSE60625 RRM2 6241 0 3 8
GSE74703 RRM2 6241 3 0 33
GSE74704 RRM2 6241 9 1 10
TCGA RRM2 6241 34 5 57

Total number of gains: 93; Total number of losses: 25; Total Number of normals: 370.  

 

Somatic mutations of RRM2:

 

Generating mutation plots.

 

Highly correlated genes for RRM2:

 

Showing top 20/641 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RRM2CDC200.7948212012
RRM2BUB1B0.790921009
RRM2TTK0.78089610010
RRM2MAD2L10.77750211011
RRM2HMMR0.76168311011
RRM2ZWINT0.75808812011
RRM2CCNA20.75473511010
RRM2MCM40.752587909
RRM2CDK10.7506411010
RRM2MELK0.75013612011
RRM2CCNB10.74998611011
RRM2PRC10.74993211010
RRM2FEN10.7471051008
RRM2BIRC50.74640211010
RRM2DLGAP50.74604213012
RRM2PBK0.74511811010
RRM2OIP50.7445461009
RRM2KIF20A0.74411911010
RRM2CDCA80.74111611010
RRM2NUSAP10.7402721109

For details and further investigation, click here