| Full name: TNF superfamily member 14 | Alias Symbol: LIGHT|LTg|HVEM-L|CD258 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 8740 | HGNC ID: HGNC:11930 | Ensembl Gene: ENSG00000125735 | OMIM ID: 604520 |
| Drug and gene relationship at DGIdb | |||
TNFSF14 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway |
Expression of TNFSF14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFSF14 | 8740 | 233935_at | -0.1373 | 0.6652 | |
| GSE20347 | TNFSF14 | 8740 | 207907_at | -0.0401 | 0.7038 | |
| GSE23400 | TNFSF14 | 8740 | 207907_at | -0.0974 | 0.0189 | |
| GSE26886 | TNFSF14 | 8740 | 207907_at | 0.0699 | 0.7772 | |
| GSE29001 | TNFSF14 | 8740 | 207907_at | 0.1596 | 0.4677 | |
| GSE38129 | TNFSF14 | 8740 | 207907_at | -0.0961 | 0.3552 | |
| GSE45670 | TNFSF14 | 8740 | 207907_at | 0.0429 | 0.8755 | |
| GSE53622 | TNFSF14 | 8740 | 38166 | 0.1275 | 0.4309 | |
| GSE53624 | TNFSF14 | 8740 | 38166 | -0.1132 | 0.3827 | |
| GSE63941 | TNFSF14 | 8740 | 207907_at | -0.1090 | 0.5919 | |
| GSE77861 | TNFSF14 | 8740 | 207907_at | 0.0008 | 0.9973 | |
| GSE97050 | TNFSF14 | 8740 | A_24_P237036 | 0.2296 | 0.3369 | |
| SRP007169 | TNFSF14 | 8740 | RNAseq | 0.9966 | 0.2405 | |
| SRP064894 | TNFSF14 | 8740 | RNAseq | 0.5014 | 0.2145 | |
| SRP133303 | TNFSF14 | 8740 | RNAseq | 0.1499 | 0.4239 | |
| SRP159526 | TNFSF14 | 8740 | RNAseq | -0.2527 | 0.5543 | |
| SRP193095 | TNFSF14 | 8740 | RNAseq | 0.0251 | 0.8298 | |
| SRP219564 | TNFSF14 | 8740 | RNAseq | 0.8274 | 0.3330 | |
| TCGA | TNFSF14 | 8740 | RNAseq | -0.2895 | 0.5201 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TNFSF14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFSF14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFSF14 | 8740 | 5 | 3 | 22 | |
| GSE20123 | TNFSF14 | 8740 | 4 | 2 | 24 | |
| GSE43470 | TNFSF14 | 8740 | 2 | 6 | 35 | |
| GSE46452 | TNFSF14 | 8740 | 47 | 1 | 11 | |
| GSE47630 | TNFSF14 | 8740 | 5 | 7 | 28 | |
| GSE54993 | TNFSF14 | 8740 | 16 | 3 | 51 | |
| GSE54994 | TNFSF14 | 8740 | 6 | 14 | 33 | |
| GSE60625 | TNFSF14 | 8740 | 9 | 0 | 2 | |
| GSE74703 | TNFSF14 | 8740 | 2 | 4 | 30 | |
| GSE74704 | TNFSF14 | 8740 | 1 | 2 | 17 | |
| TCGA | TNFSF14 | 8740 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of TNFSF14:
Generating mutation plots.
Highly correlated genes for TNFSF14:
Showing top 20/192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFSF14 | ANKRD30B | 0.818962 | 3 | 0 | 3 |
| TNFSF14 | UBE2O | 0.761354 | 3 | 0 | 3 |
| TNFSF14 | MSL3 | 0.750137 | 3 | 0 | 3 |
| TNFSF14 | FAM131B | 0.732601 | 3 | 0 | 3 |
| TNFSF14 | KLHL28 | 0.730338 | 3 | 0 | 3 |
| TNFSF14 | LIPF | 0.73011 | 3 | 0 | 3 |
| TNFSF14 | PLIN4 | 0.722892 | 3 | 0 | 3 |
| TNFSF14 | HGS | 0.722171 | 3 | 0 | 3 |
| TNFSF14 | LLPH | 0.721346 | 3 | 0 | 3 |
| TNFSF14 | DMAP1 | 0.715834 | 3 | 0 | 3 |
| TNFSF14 | XPNPEP1 | 0.709107 | 3 | 0 | 3 |
| TNFSF14 | CCDC65 | 0.705909 | 3 | 0 | 3 |
| TNFSF14 | EGLN2 | 0.705696 | 3 | 0 | 3 |
| TNFSF14 | DHDH | 0.698002 | 3 | 0 | 3 |
| TNFSF14 | AMOTL2 | 0.693536 | 3 | 0 | 3 |
| TNFSF14 | TAGAP | 0.690146 | 4 | 0 | 3 |
| TNFSF14 | ANKRD44 | 0.685814 | 4 | 0 | 3 |
| TNFSF14 | C19orf38 | 0.682711 | 4 | 0 | 3 |
| TNFSF14 | KCNJ2 | 0.677903 | 3 | 0 | 3 |
| TNFSF14 | XPNPEP3 | 0.677606 | 4 | 0 | 4 |
For details and further investigation, click here
