| Full name: hepatocyte growth factor-regulated tyrosine kinase substrate | Alias Symbol: Hrs|ZFYVE8|Vps27 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 9146 | HGNC ID: HGNC:4897 | Ensembl Gene: ENSG00000185359 | OMIM ID: 604375 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HGS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HGS | 9146 | 210428_s_at | 0.5489 | 0.2828 | |
| GSE20347 | HGS | 9146 | 210428_s_at | 0.0771 | 0.6069 | |
| GSE23400 | HGS | 9146 | 210428_s_at | 0.2311 | 0.0011 | |
| GSE26886 | HGS | 9146 | 210428_s_at | -0.1492 | 0.4543 | |
| GSE29001 | HGS | 9146 | 210428_s_at | 0.0799 | 0.8699 | |
| GSE38129 | HGS | 9146 | 210428_s_at | 0.2462 | 0.0386 | |
| GSE45670 | HGS | 9146 | 210428_s_at | 0.3838 | 0.0033 | |
| GSE63941 | HGS | 9146 | 210428_s_at | 0.5367 | 0.0653 | |
| GSE77861 | HGS | 9146 | 210428_s_at | 0.1120 | 0.6341 | |
| GSE97050 | HGS | 9146 | A_23_P72627 | 0.3346 | 0.1782 | |
| SRP007169 | HGS | 9146 | RNAseq | -0.0816 | 0.8618 | |
| SRP008496 | HGS | 9146 | RNAseq | -0.3597 | 0.2351 | |
| SRP064894 | HGS | 9146 | RNAseq | 0.5712 | 0.0013 | |
| SRP133303 | HGS | 9146 | RNAseq | 0.2190 | 0.2405 | |
| SRP159526 | HGS | 9146 | RNAseq | -0.0003 | 0.9984 | |
| SRP193095 | HGS | 9146 | RNAseq | 0.2472 | 0.0099 | |
| SRP219564 | HGS | 9146 | RNAseq | 0.0941 | 0.7789 | |
| TCGA | HGS | 9146 | RNAseq | 0.1059 | 0.0151 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HGS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HGS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HGS | 9146 | 4 | 4 | 22 | |
| GSE20123 | HGS | 9146 | 4 | 4 | 22 | |
| GSE43470 | HGS | 9146 | 3 | 5 | 35 | |
| GSE46452 | HGS | 9146 | 34 | 0 | 25 | |
| GSE47630 | HGS | 9146 | 9 | 2 | 29 | |
| GSE54993 | HGS | 9146 | 2 | 5 | 63 | |
| GSE54994 | HGS | 9146 | 10 | 6 | 37 | |
| GSE60625 | HGS | 9146 | 6 | 0 | 5 | |
| GSE74703 | HGS | 9146 | 3 | 3 | 30 | |
| GSE74704 | HGS | 9146 | 4 | 3 | 13 | |
| TCGA | HGS | 9146 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of HGS:
Generating mutation plots.
Highly correlated genes for HGS:
Showing top 20/606 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HGS | PACS1 | 0.842825 | 3 | 0 | 3 |
| HGS | YIPF3 | 0.808402 | 3 | 0 | 3 |
| HGS | TSEN34 | 0.795334 | 3 | 0 | 3 |
| HGS | DOCK6 | 0.763719 | 6 | 0 | 6 |
| HGS | SGSH | 0.763048 | 5 | 0 | 4 |
| HGS | MORC2 | 0.755243 | 3 | 0 | 3 |
| HGS | TMEM63B | 0.745491 | 3 | 0 | 3 |
| HGS | NAA25 | 0.745444 | 3 | 0 | 3 |
| HGS | WDR4 | 0.733368 | 3 | 0 | 3 |
| HGS | USP36 | 0.73267 | 4 | 0 | 4 |
| HGS | PLXNA1 | 0.73135 | 3 | 0 | 3 |
| HGS | NACC1 | 0.729719 | 4 | 0 | 3 |
| HGS | TDG | 0.727827 | 4 | 0 | 4 |
| HGS | SSBP4 | 0.727358 | 3 | 0 | 3 |
| HGS | DHX30 | 0.727325 | 3 | 0 | 3 |
| HGS | FAM53B | 0.725595 | 4 | 0 | 3 |
| HGS | TMEM160 | 0.723788 | 3 | 0 | 3 |
| HGS | DDX6 | 0.722984 | 3 | 0 | 3 |
| HGS | SLC39A7 | 0.722948 | 3 | 0 | 3 |
| HGS | TNFSF14 | 0.722171 | 3 | 0 | 3 |
For details and further investigation, click here
