| Full name: angiomotin like 2 | Alias Symbol: LCCP | ||
| Type: protein-coding gene | Cytoband: 3q22.2 | ||
| Entrez ID: 51421 | HGNC ID: HGNC:17812 | Ensembl Gene: ENSG00000114019 | OMIM ID: 614658 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AMOTL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AMOTL2 | 51421 | 203002_at | -0.9524 | 0.2157 | |
| GSE20347 | AMOTL2 | 51421 | 203002_at | -1.3005 | 0.0000 | |
| GSE23400 | AMOTL2 | 51421 | 203002_at | -1.0969 | 0.0000 | |
| GSE26886 | AMOTL2 | 51421 | 203002_at | -1.1808 | 0.0000 | |
| GSE29001 | AMOTL2 | 51421 | 203002_at | -0.7589 | 0.0072 | |
| GSE38129 | AMOTL2 | 51421 | 203002_at | -1.2909 | 0.0000 | |
| GSE45670 | AMOTL2 | 51421 | 203002_at | -0.6997 | 0.0052 | |
| GSE53622 | AMOTL2 | 51421 | 77748 | -1.3261 | 0.0000 | |
| GSE53624 | AMOTL2 | 51421 | 77748 | -1.4530 | 0.0000 | |
| GSE63941 | AMOTL2 | 51421 | 203002_at | -0.7429 | 0.1714 | |
| GSE77861 | AMOTL2 | 51421 | 203002_at | -0.9547 | 0.0046 | |
| GSE97050 | AMOTL2 | 51421 | A_23_P166686 | -0.7912 | 0.0849 | |
| SRP007169 | AMOTL2 | 51421 | RNAseq | -2.7035 | 0.0000 | |
| SRP008496 | AMOTL2 | 51421 | RNAseq | -2.5372 | 0.0000 | |
| SRP064894 | AMOTL2 | 51421 | RNAseq | -1.8322 | 0.0000 | |
| SRP133303 | AMOTL2 | 51421 | RNAseq | -1.3949 | 0.0000 | |
| SRP159526 | AMOTL2 | 51421 | RNAseq | -1.5080 | 0.0000 | |
| SRP193095 | AMOTL2 | 51421 | RNAseq | -0.8628 | 0.0001 | |
| SRP219564 | AMOTL2 | 51421 | RNAseq | -0.9872 | 0.0280 | |
| TCGA | AMOTL2 | 51421 | RNAseq | -0.1298 | 0.0436 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by AMOTL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AMOTL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AMOTL2 | 51421 | 16 | 0 | 14 | |
| GSE20123 | AMOTL2 | 51421 | 16 | 0 | 14 | |
| GSE43470 | AMOTL2 | 51421 | 21 | 0 | 22 | |
| GSE46452 | AMOTL2 | 51421 | 15 | 4 | 40 | |
| GSE47630 | AMOTL2 | 51421 | 18 | 3 | 19 | |
| GSE54993 | AMOTL2 | 51421 | 2 | 8 | 60 | |
| GSE54994 | AMOTL2 | 51421 | 32 | 1 | 20 | |
| GSE60625 | AMOTL2 | 51421 | 0 | 6 | 5 | |
| GSE74703 | AMOTL2 | 51421 | 18 | 0 | 18 | |
| GSE74704 | AMOTL2 | 51421 | 11 | 0 | 9 | |
| TCGA | AMOTL2 | 51421 | 59 | 5 | 32 |
Total number of gains: 208; Total number of losses: 27; Total Number of normals: 253.
Somatic mutations of AMOTL2:
Generating mutation plots.
Highly correlated genes for AMOTL2:
Showing top 20/1220 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AMOTL2 | NDUFV2 | 0.772223 | 3 | 0 | 3 |
| AMOTL2 | TRIP10 | 0.756328 | 11 | 0 | 11 |
| AMOTL2 | KIF1C | 0.74671 | 11 | 0 | 11 |
| AMOTL2 | ERGIC1 | 0.746368 | 3 | 0 | 3 |
| AMOTL2 | PDLIM2 | 0.743399 | 10 | 0 | 10 |
| AMOTL2 | CA13 | 0.737799 | 3 | 0 | 3 |
| AMOTL2 | KRT78 | 0.736824 | 6 | 0 | 6 |
| AMOTL2 | KRT33B | 0.734993 | 3 | 0 | 3 |
| AMOTL2 | MTHFR | 0.731378 | 3 | 0 | 3 |
| AMOTL2 | EPS8L1 | 0.730755 | 10 | 0 | 9 |
| AMOTL2 | PHYHIPL | 0.730688 | 3 | 0 | 3 |
| AMOTL2 | RAB5B | 0.730228 | 11 | 0 | 11 |
| AMOTL2 | MAGI3 | 0.729058 | 6 | 0 | 6 |
| AMOTL2 | MGLL | 0.726679 | 12 | 0 | 12 |
| AMOTL2 | IQCF1 | 0.726147 | 3 | 0 | 3 |
| AMOTL2 | ZNF175 | 0.725602 | 3 | 0 | 3 |
| AMOTL2 | ANKRD13A | 0.723503 | 7 | 0 | 7 |
| AMOTL2 | CLEC3B | 0.72091 | 3 | 0 | 3 |
| AMOTL2 | SLAIN2 | 0.720763 | 5 | 0 | 4 |
| AMOTL2 | LACTBL1 | 0.720634 | 3 | 0 | 3 |
For details and further investigation, click here
