| Full name: tyrosine kinase non receptor 2 | Alias Symbol: p21cdc42Hs|ACK|ACK1 | ||
| Type: protein-coding gene | Cytoband: 3q29 | ||
| Entrez ID: 10188 | HGNC ID: HGNC:19297 | Ensembl Gene: ENSG00000061938 | OMIM ID: 606994 |
| Drug and gene relationship at DGIdb | |||
Expression of TNK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNK2 | 10188 | 203839_s_at | 0.5458 | 0.3884 | |
| GSE20347 | TNK2 | 10188 | 203839_s_at | 0.1800 | 0.0649 | |
| GSE23400 | TNK2 | 10188 | 203839_s_at | 0.0991 | 0.1284 | |
| GSE26886 | TNK2 | 10188 | 203839_s_at | 0.4327 | 0.0302 | |
| GSE29001 | TNK2 | 10188 | 203839_s_at | 0.1303 | 0.6295 | |
| GSE38129 | TNK2 | 10188 | 203839_s_at | 0.1754 | 0.1089 | |
| GSE45670 | TNK2 | 10188 | 203839_s_at | 0.2360 | 0.0818 | |
| GSE53622 | TNK2 | 10188 | 98815 | -0.0359 | 0.6517 | |
| GSE53624 | TNK2 | 10188 | 98815 | 0.0677 | 0.3114 | |
| GSE63941 | TNK2 | 10188 | 203839_s_at | -0.1509 | 0.5621 | |
| GSE77861 | TNK2 | 10188 | 203839_s_at | -0.0018 | 0.9927 | |
| GSE97050 | TNK2 | 10188 | A_23_P61633 | -0.3558 | 0.4815 | |
| SRP007169 | TNK2 | 10188 | RNAseq | 0.0323 | 0.9462 | |
| SRP008496 | TNK2 | 10188 | RNAseq | -0.1479 | 0.5898 | |
| SRP064894 | TNK2 | 10188 | RNAseq | 0.3838 | 0.0744 | |
| SRP133303 | TNK2 | 10188 | RNAseq | 0.2143 | 0.2805 | |
| SRP159526 | TNK2 | 10188 | RNAseq | 0.6272 | 0.0295 | |
| SRP193095 | TNK2 | 10188 | RNAseq | 0.5563 | 0.0009 | |
| SRP219564 | TNK2 | 10188 | RNAseq | 0.2809 | 0.5434 | |
| TCGA | TNK2 | 10188 | RNAseq | 0.2365 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TNK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNK2 | 10188 | 22 | 0 | 8 | |
| GSE20123 | TNK2 | 10188 | 22 | 0 | 8 | |
| GSE43470 | TNK2 | 10188 | 21 | 0 | 22 | |
| GSE46452 | TNK2 | 10188 | 19 | 1 | 39 | |
| GSE47630 | TNK2 | 10188 | 27 | 2 | 11 | |
| GSE54993 | TNK2 | 10188 | 1 | 22 | 47 | |
| GSE54994 | TNK2 | 10188 | 41 | 0 | 12 | |
| GSE60625 | TNK2 | 10188 | 0 | 6 | 5 | |
| GSE74703 | TNK2 | 10188 | 19 | 0 | 17 | |
| GSE74704 | TNK2 | 10188 | 14 | 0 | 6 | |
| TCGA | TNK2 | 10188 | 77 | 0 | 19 |
Total number of gains: 263; Total number of losses: 31; Total Number of normals: 194.
Somatic mutations of TNK2:
Generating mutation plots.
Highly correlated genes for TNK2:
Showing top 20/258 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNK2 | CCDC152 | 0.741637 | 3 | 0 | 3 |
| TNK2 | CBS | 0.71659 | 3 | 0 | 3 |
| TNK2 | TET3 | 0.679421 | 3 | 0 | 3 |
| TNK2 | NAPSA | 0.674564 | 3 | 0 | 3 |
| TNK2 | KCTD17 | 0.667155 | 5 | 0 | 5 |
| TNK2 | IGSF9 | 0.66153 | 4 | 0 | 3 |
| TNK2 | SAMD1 | 0.652624 | 3 | 0 | 3 |
| TNK2 | NKAIN1 | 0.649322 | 3 | 0 | 3 |
| TNK2 | FAM53A | 0.648925 | 4 | 0 | 3 |
| TNK2 | ZNF358 | 0.646642 | 3 | 0 | 3 |
| TNK2 | LRRC56 | 0.644288 | 3 | 0 | 3 |
| TNK2 | MYO7A | 0.640416 | 3 | 0 | 3 |
| TNK2 | SPIRE2 | 0.635229 | 4 | 0 | 3 |
| TNK2 | SLC7A9 | 0.634956 | 4 | 0 | 4 |
| TNK2 | RBFOX1 | 0.634493 | 4 | 0 | 3 |
| TNK2 | PPP1R37 | 0.633279 | 4 | 0 | 4 |
| TNK2 | SCT | 0.632692 | 3 | 0 | 3 |
| TNK2 | PNKP | 0.63153 | 3 | 0 | 3 |
| TNK2 | GMEB2 | 0.629904 | 7 | 0 | 6 |
| TNK2 | ANKRD10-IT1 | 0.629487 | 4 | 0 | 3 |
For details and further investigation, click here
