| Full name: spire type actin nucleation factor 2 | Alias Symbol: spir-2|KIAA1832 | ||
| Type: protein-coding gene | Cytoband: 16q24 | ||
| Entrez ID: 84501 | HGNC ID: HGNC:30623 | Ensembl Gene: ENSG00000204991 | OMIM ID: 609217 |
| Drug and gene relationship at DGIdb | |||
Expression of SPIRE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPIRE2 | 84501 | 243594_x_at | 0.4944 | 0.3774 | |
| GSE26886 | SPIRE2 | 84501 | 243594_x_at | 0.3864 | 0.0305 | |
| GSE45670 | SPIRE2 | 84501 | 243594_x_at | 0.5459 | 0.0041 | |
| GSE53622 | SPIRE2 | 84501 | 63169 | -0.3000 | 0.1965 | |
| GSE53624 | SPIRE2 | 84501 | 63169 | 0.3236 | 0.0374 | |
| GSE63941 | SPIRE2 | 84501 | 243594_x_at | 0.1312 | 0.8029 | |
| GSE77861 | SPIRE2 | 84501 | 243594_x_at | 0.1019 | 0.6536 | |
| GSE97050 | SPIRE2 | 84501 | A_33_P3210203 | 0.1849 | 0.6431 | |
| SRP007169 | SPIRE2 | 84501 | RNAseq | 1.4861 | 0.0484 | |
| SRP064894 | SPIRE2 | 84501 | RNAseq | 1.0468 | 0.0020 | |
| SRP133303 | SPIRE2 | 84501 | RNAseq | 1.0429 | 0.0151 | |
| SRP159526 | SPIRE2 | 84501 | RNAseq | 1.2746 | 0.0382 | |
| SRP193095 | SPIRE2 | 84501 | RNAseq | -0.3208 | 0.3587 | |
| SRP219564 | SPIRE2 | 84501 | RNAseq | 0.8435 | 0.0610 | |
| TCGA | SPIRE2 | 84501 | RNAseq | -0.4000 | 0.0558 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SPIRE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPIRE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPIRE2 | 84501 | 4 | 3 | 23 | |
| GSE20123 | SPIRE2 | 84501 | 4 | 3 | 23 | |
| GSE43470 | SPIRE2 | 84501 | 1 | 13 | 29 | |
| GSE46452 | SPIRE2 | 84501 | 38 | 1 | 20 | |
| GSE47630 | SPIRE2 | 84501 | 11 | 9 | 20 | |
| GSE54993 | SPIRE2 | 84501 | 3 | 4 | 63 | |
| GSE54994 | SPIRE2 | 84501 | 9 | 11 | 33 | |
| GSE60625 | SPIRE2 | 84501 | 4 | 0 | 7 | |
| GSE74703 | SPIRE2 | 84501 | 1 | 9 | 26 | |
| GSE74704 | SPIRE2 | 84501 | 3 | 1 | 16 | |
| TCGA | SPIRE2 | 84501 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of SPIRE2:
Generating mutation plots.
Highly correlated genes for SPIRE2:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPIRE2 | CCAR1 | 0.786482 | 3 | 0 | 3 |
| SPIRE2 | AAK1 | 0.770531 | 3 | 0 | 3 |
| SPIRE2 | OPLAH | 0.767336 | 3 | 0 | 3 |
| SPIRE2 | BRD9 | 0.759015 | 3 | 0 | 3 |
| SPIRE2 | METTL3 | 0.754302 | 3 | 0 | 3 |
| SPIRE2 | LSM4 | 0.746505 | 3 | 0 | 3 |
| SPIRE2 | KRI1 | 0.731283 | 4 | 0 | 4 |
| SPIRE2 | VANGL2 | 0.730051 | 3 | 0 | 3 |
| SPIRE2 | HMGXB4 | 0.728866 | 3 | 0 | 3 |
| SPIRE2 | HPS4 | 0.724421 | 3 | 0 | 3 |
| SPIRE2 | CSPP1 | 0.724014 | 4 | 0 | 3 |
| SPIRE2 | BRD4 | 0.723797 | 4 | 0 | 4 |
| SPIRE2 | SRRD | 0.721794 | 3 | 0 | 3 |
| SPIRE2 | RPL8 | 0.715321 | 3 | 0 | 3 |
| SPIRE2 | GTPBP8 | 0.714087 | 4 | 0 | 4 |
| SPIRE2 | PRKCI | 0.713998 | 3 | 0 | 3 |
| SPIRE2 | CPT1C | 0.713365 | 3 | 0 | 3 |
| SPIRE2 | MADD | 0.712853 | 3 | 0 | 3 |
| SPIRE2 | FAM184B | 0.711444 | 3 | 0 | 3 |
| SPIRE2 | CACNA1B | 0.710419 | 3 | 0 | 3 |
For details and further investigation, click here
