| Full name: family with sequence similarity 189 member A2 | Alias Symbol: X123 | ||
| Type: protein-coding gene | Cytoband: 9q21.12 | ||
| Entrez ID: 9413 | HGNC ID: HGNC:24820 | Ensembl Gene: ENSG00000135063 | OMIM ID: 607710 |
| Drug and gene relationship at DGIdb | |||
Expression of FAM189A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAM189A2 | 9413 | 213900_at | -1.7513 | 0.0265 | |
| GSE20347 | FAM189A2 | 9413 | 213900_at | -1.2608 | 0.0000 | |
| GSE23400 | FAM189A2 | 9413 | 213900_at | -0.6412 | 0.0000 | |
| GSE26886 | FAM189A2 | 9413 | 213900_at | -1.2745 | 0.0002 | |
| GSE29001 | FAM189A2 | 9413 | 213900_at | -1.6031 | 0.0000 | |
| GSE38129 | FAM189A2 | 9413 | 213900_at | -1.6837 | 0.0000 | |
| GSE45670 | FAM189A2 | 9413 | 213900_at | -1.1399 | 0.0001 | |
| GSE53622 | FAM189A2 | 9413 | 57317 | -2.6534 | 0.0000 | |
| GSE53624 | FAM189A2 | 9413 | 57317 | -3.2228 | 0.0000 | |
| GSE63941 | FAM189A2 | 9413 | 213900_at | 0.3805 | 0.3488 | |
| GSE77861 | FAM189A2 | 9413 | 213900_at | -0.6667 | 0.0022 | |
| GSE97050 | FAM189A2 | 9413 | A_32_P43717 | -0.5234 | 0.3181 | |
| SRP007169 | FAM189A2 | 9413 | RNAseq | -1.4031 | 0.1013 | |
| SRP064894 | FAM189A2 | 9413 | RNAseq | -1.5142 | 0.0000 | |
| SRP133303 | FAM189A2 | 9413 | RNAseq | -2.1608 | 0.0000 | |
| SRP193095 | FAM189A2 | 9413 | RNAseq | -2.2804 | 0.0000 | |
| SRP219564 | FAM189A2 | 9413 | RNAseq | -1.4969 | 0.1075 | |
| TCGA | FAM189A2 | 9413 | RNAseq | -1.8441 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by FAM189A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAM189A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAM189A2 | 9413 | 6 | 10 | 14 | |
| GSE20123 | FAM189A2 | 9413 | 6 | 10 | 14 | |
| GSE43470 | FAM189A2 | 9413 | 6 | 5 | 32 | |
| GSE46452 | FAM189A2 | 9413 | 7 | 14 | 38 | |
| GSE47630 | FAM189A2 | 9413 | 1 | 19 | 20 | |
| GSE54993 | FAM189A2 | 9413 | 5 | 1 | 64 | |
| GSE54994 | FAM189A2 | 9413 | 4 | 13 | 36 | |
| GSE60625 | FAM189A2 | 9413 | 0 | 0 | 11 | |
| GSE74703 | FAM189A2 | 9413 | 5 | 4 | 27 | |
| GSE74704 | FAM189A2 | 9413 | 3 | 7 | 10 | |
| TCGA | FAM189A2 | 9413 | 19 | 28 | 49 |
Total number of gains: 62; Total number of losses: 111; Total Number of normals: 315.
Somatic mutations of FAM189A2:
Generating mutation plots.
Highly correlated genes for FAM189A2:
Showing top 20/869 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAM189A2 | SH3BGRL2 | 0.825074 | 6 | 0 | 6 |
| FAM189A2 | SHROOM3 | 0.784978 | 6 | 0 | 6 |
| FAM189A2 | FAM219B | 0.774097 | 4 | 0 | 4 |
| FAM189A2 | SORBS2 | 0.765608 | 10 | 0 | 10 |
| FAM189A2 | SUOX | 0.74628 | 10 | 0 | 10 |
| FAM189A2 | TNXB | 0.745963 | 4 | 0 | 3 |
| FAM189A2 | XKR4 | 0.739777 | 4 | 0 | 4 |
| FAM189A2 | GAB2 | 0.738485 | 11 | 0 | 11 |
| FAM189A2 | BTC | 0.738354 | 9 | 0 | 9 |
| FAM189A2 | BOC | 0.734394 | 6 | 0 | 6 |
| FAM189A2 | KAT2B | 0.731189 | 10 | 0 | 10 |
| FAM189A2 | COBL | 0.728089 | 10 | 0 | 10 |
| FAM189A2 | MPC1 | 0.725737 | 10 | 0 | 10 |
| FAM189A2 | PPP1R3C | 0.725687 | 10 | 0 | 10 |
| FAM189A2 | AK9 | 0.724807 | 6 | 0 | 6 |
| FAM189A2 | FAM95B1 | 0.724123 | 4 | 0 | 4 |
| FAM189A2 | UBL3 | 0.721946 | 10 | 0 | 10 |
| FAM189A2 | KIAA0232 | 0.71796 | 11 | 0 | 11 |
| FAM189A2 | TFAP2B | 0.71688 | 10 | 0 | 10 |
| FAM189A2 | SLC27A6 | 0.714205 | 11 | 0 | 10 |
For details and further investigation, click here
