| Full name: 4-aminobutyrate aminotransferase | Alias Symbol: GABAT|GABA-T | ||
| Type: protein-coding gene | Cytoband: 16p13.2 | ||
| Entrez ID: 18 | HGNC ID: HGNC:23 | Ensembl Gene: ENSG00000183044 | OMIM ID: 137150 |
| Drug and gene relationship at DGIdb | |||
Expression of ABAT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABAT | 18 | 209459_s_at | -0.7929 | 0.5455 | |
| GSE20347 | ABAT | 18 | 209459_s_at | -2.1136 | 0.0000 | |
| GSE23400 | ABAT | 18 | 206527_at | -0.2940 | 0.0000 | |
| GSE26886 | ABAT | 18 | 209459_s_at | -1.4458 | 0.0129 | |
| GSE29001 | ABAT | 18 | 209459_s_at | -2.2623 | 0.0064 | |
| GSE38129 | ABAT | 18 | 209459_s_at | -1.7718 | 0.0000 | |
| GSE45670 | ABAT | 18 | 209460_at | -0.8382 | 0.0553 | |
| GSE53622 | ABAT | 18 | 122943 | -1.3591 | 0.0000 | |
| GSE53624 | ABAT | 18 | 122943 | -1.7561 | 0.0000 | |
| GSE63941 | ABAT | 18 | 209459_s_at | -1.4165 | 0.1791 | |
| GSE77861 | ABAT | 18 | 206527_at | -0.4411 | 0.0061 | |
| GSE97050 | ABAT | 18 | A_33_P3366161 | -0.2128 | 0.3040 | |
| SRP007169 | ABAT | 18 | RNAseq | -2.6881 | 0.0000 | |
| SRP008496 | ABAT | 18 | RNAseq | -2.5181 | 0.0000 | |
| SRP064894 | ABAT | 18 | RNAseq | -1.7539 | 0.0000 | |
| SRP133303 | ABAT | 18 | RNAseq | -1.0451 | 0.0000 | |
| SRP159526 | ABAT | 18 | RNAseq | -2.6654 | 0.0000 | |
| SRP193095 | ABAT | 18 | RNAseq | -1.6560 | 0.0000 | |
| SRP219564 | ABAT | 18 | RNAseq | -1.0385 | 0.0275 | |
| TCGA | ABAT | 18 | RNAseq | -0.4946 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by ABAT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABAT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABAT | 18 | 4 | 4 | 22 | |
| GSE20123 | ABAT | 18 | 4 | 3 | 23 | |
| GSE43470 | ABAT | 18 | 3 | 2 | 38 | |
| GSE46452 | ABAT | 18 | 38 | 1 | 20 | |
| GSE47630 | ABAT | 18 | 13 | 6 | 21 | |
| GSE54993 | ABAT | 18 | 3 | 5 | 62 | |
| GSE54994 | ABAT | 18 | 5 | 9 | 39 | |
| GSE60625 | ABAT | 18 | 4 | 0 | 7 | |
| GSE74703 | ABAT | 18 | 3 | 2 | 31 | |
| GSE74704 | ABAT | 18 | 2 | 1 | 17 | |
| TCGA | ABAT | 18 | 21 | 12 | 63 |
Total number of gains: 100; Total number of losses: 45; Total Number of normals: 343.
Somatic mutations of ABAT:
Generating mutation plots.
Highly correlated genes for ABAT:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABAT | SUDS3 | 0.747433 | 3 | 0 | 3 |
| ABAT | TRIM41 | 0.746273 | 3 | 0 | 3 |
| ABAT | DGAT2 | 0.724858 | 3 | 0 | 3 |
| ABAT | KIAA1211L | 0.703345 | 5 | 0 | 5 |
| ABAT | SLC37A1 | 0.697575 | 10 | 0 | 10 |
| ABAT | TNNI2 | 0.688202 | 4 | 0 | 4 |
| ABAT | RIPK4 | 0.67888 | 7 | 0 | 6 |
| ABAT | ACBD4 | 0.678443 | 3 | 0 | 3 |
| ABAT | MOS | 0.672786 | 5 | 0 | 4 |
| ABAT | VSIG10 | 0.67116 | 5 | 0 | 4 |
| ABAT | OR10G8 | 0.671054 | 3 | 0 | 3 |
| ABAT | FBF1 | 0.665649 | 4 | 0 | 3 |
| ABAT | MAGIX | 0.658326 | 5 | 0 | 3 |
| ABAT | EPHA1 | 0.656572 | 8 | 0 | 7 |
| ABAT | EPS8L2 | 0.655962 | 11 | 0 | 11 |
| ABAT | HHATL | 0.651656 | 4 | 0 | 3 |
| ABAT | TSHB | 0.649791 | 4 | 0 | 3 |
| ABAT | MUC22 | 0.649075 | 3 | 0 | 3 |
| ABAT | EPB41L4A | 0.648045 | 7 | 0 | 7 |
| ABAT | NCR1 | 0.646216 | 3 | 0 | 3 |
For details and further investigation, click here
