| Full name: nischarin | Alias Symbol: KIAA0975|I-1|IRAS | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 11188 | HGNC ID: HGNC:18006 | Ensembl Gene: ENSG00000010322 | OMIM ID: 615507 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NISCH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NISCH | 11188 | 201591_s_at | -0.3306 | 0.3200 | |
| GSE20347 | NISCH | 11188 | 201591_s_at | -0.4062 | 0.0018 | |
| GSE23400 | NISCH | 11188 | 201591_s_at | -0.2635 | 0.0000 | |
| GSE26886 | NISCH | 11188 | 201591_s_at | -0.9182 | 0.0001 | |
| GSE29001 | NISCH | 11188 | 201591_s_at | -0.3292 | 0.5031 | |
| GSE38129 | NISCH | 11188 | 201591_s_at | -0.4950 | 0.0002 | |
| GSE45670 | NISCH | 11188 | 201591_s_at | -0.3826 | 0.0165 | |
| GSE53622 | NISCH | 11188 | 64188 | -0.5294 | 0.0000 | |
| GSE53624 | NISCH | 11188 | 64188 | -0.3804 | 0.0000 | |
| GSE63941 | NISCH | 11188 | 201591_s_at | -1.2975 | 0.0021 | |
| GSE77861 | NISCH | 11188 | 201591_s_at | -0.2964 | 0.1346 | |
| GSE97050 | NISCH | 11188 | A_24_P405621 | -0.1928 | 0.5600 | |
| SRP007169 | NISCH | 11188 | RNAseq | -0.4820 | 0.2695 | |
| SRP008496 | NISCH | 11188 | RNAseq | -0.4976 | 0.1085 | |
| SRP064894 | NISCH | 11188 | RNAseq | -0.1195 | 0.5267 | |
| SRP133303 | NISCH | 11188 | RNAseq | -0.7837 | 0.0000 | |
| SRP159526 | NISCH | 11188 | RNAseq | -0.7274 | 0.0004 | |
| SRP193095 | NISCH | 11188 | RNAseq | -0.3156 | 0.0056 | |
| SRP219564 | NISCH | 11188 | RNAseq | -0.8020 | 0.0256 | |
| TCGA | NISCH | 11188 | RNAseq | -0.2942 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NISCH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NISCH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NISCH | 11188 | 0 | 18 | 12 | |
| GSE20123 | NISCH | 11188 | 0 | 19 | 11 | |
| GSE43470 | NISCH | 11188 | 0 | 18 | 25 | |
| GSE46452 | NISCH | 11188 | 2 | 17 | 40 | |
| GSE47630 | NISCH | 11188 | 1 | 24 | 15 | |
| GSE54993 | NISCH | 11188 | 6 | 2 | 62 | |
| GSE54994 | NISCH | 11188 | 0 | 33 | 20 | |
| GSE60625 | NISCH | 11188 | 5 | 0 | 6 | |
| GSE74703 | NISCH | 11188 | 0 | 14 | 22 | |
| GSE74704 | NISCH | 11188 | 0 | 12 | 8 | |
| TCGA | NISCH | 11188 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of NISCH:
Generating mutation plots.
Highly correlated genes for NISCH:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NISCH | WDR44 | 0.752668 | 3 | 0 | 3 |
| NISCH | PNPLA7 | 0.745819 | 4 | 0 | 4 |
| NISCH | SEMA5A | 0.699213 | 5 | 0 | 5 |
| NISCH | GDF7 | 0.689854 | 3 | 0 | 3 |
| NISCH | GGA1 | 0.672826 | 4 | 0 | 4 |
| NISCH | GNB3 | 0.671592 | 3 | 0 | 3 |
| NISCH | NCAN | 0.670563 | 3 | 0 | 3 |
| NISCH | GKAP1 | 0.662777 | 4 | 0 | 4 |
| NISCH | SNX21 | 0.659611 | 4 | 0 | 4 |
| NISCH | ATP6AP1L | 0.658465 | 5 | 0 | 5 |
| NISCH | TP53INP1 | 0.655838 | 4 | 0 | 4 |
| NISCH | SHISA6 | 0.655458 | 3 | 0 | 3 |
| NISCH | KRTAP6-1 | 0.654045 | 3 | 0 | 3 |
| NISCH | SPRY3 | 0.652394 | 4 | 0 | 3 |
| NISCH | D2HGDH | 0.647392 | 6 | 0 | 6 |
| NISCH | SSTR2 | 0.639698 | 3 | 0 | 3 |
| NISCH | ETHE1 | 0.638733 | 3 | 0 | 3 |
| NISCH | TPRX1 | 0.633228 | 3 | 0 | 3 |
| NISCH | GRIPAP1 | 0.631815 | 5 | 0 | 3 |
| NISCH | SH3BP5-AS1 | 0.631276 | 5 | 0 | 5 |
For details and further investigation, click here
