| Full name: roundabout guidance receptor 2 | Alias Symbol: KIAA1568 | ||
| Type: protein-coding gene | Cytoband: 3p12.3 | ||
| Entrez ID: 6092 | HGNC ID: HGNC:10250 | Ensembl Gene: ENSG00000185008 | OMIM ID: 602431 |
| Drug and gene relationship at DGIdb | |||
ROBO2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of ROBO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ROBO2 | 6092 | 226766_at | -1.5774 | 0.1301 | |
| GSE26886 | ROBO2 | 6092 | 226766_at | -1.5108 | 0.0018 | |
| GSE45670 | ROBO2 | 6092 | 226766_at | -0.8939 | 0.0237 | |
| GSE53622 | ROBO2 | 6092 | 68091 | -1.2341 | 0.0000 | |
| GSE53624 | ROBO2 | 6092 | 68091 | -1.6419 | 0.0000 | |
| GSE63941 | ROBO2 | 6092 | 226766_at | -4.0960 | 0.0001 | |
| GSE77861 | ROBO2 | 6092 | 226766_at | -0.3582 | 0.0237 | |
| GSE97050 | ROBO2 | 6092 | A_24_P16326 | -0.1214 | 0.7968 | |
| SRP007169 | ROBO2 | 6092 | RNAseq | -0.6030 | 0.3083 | |
| SRP008496 | ROBO2 | 6092 | RNAseq | -0.1378 | 0.7752 | |
| SRP064894 | ROBO2 | 6092 | RNAseq | -2.0855 | 0.0000 | |
| SRP133303 | ROBO2 | 6092 | RNAseq | -0.9262 | 0.0213 | |
| SRP159526 | ROBO2 | 6092 | RNAseq | -0.5438 | 0.1446 | |
| SRP193095 | ROBO2 | 6092 | RNAseq | -1.7045 | 0.0000 | |
| TCGA | ROBO2 | 6092 | RNAseq | 0.6155 | 0.0809 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ROBO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ROBO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ROBO2 | 6092 | 3 | 18 | 9 | |
| GSE20123 | ROBO2 | 6092 | 3 | 18 | 9 | |
| GSE43470 | ROBO2 | 6092 | 0 | 21 | 22 | |
| GSE46452 | ROBO2 | 6092 | 2 | 17 | 40 | |
| GSE47630 | ROBO2 | 6092 | 3 | 20 | 17 | |
| GSE54993 | ROBO2 | 6092 | 4 | 3 | 63 | |
| GSE54994 | ROBO2 | 6092 | 1 | 30 | 22 | |
| GSE60625 | ROBO2 | 6092 | 3 | 1 | 7 | |
| GSE74703 | ROBO2 | 6092 | 0 | 18 | 18 | |
| GSE74704 | ROBO2 | 6092 | 2 | 13 | 5 | |
| TCGA | ROBO2 | 6092 | 1 | 77 | 18 |
Total number of gains: 22; Total number of losses: 236; Total Number of normals: 230.
Somatic mutations of ROBO2:
Generating mutation plots.
Highly correlated genes for ROBO2:
Showing top 20/365 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ROBO2 | MAML3 | 0.743909 | 3 | 0 | 3 |
| ROBO2 | ARHGEF26 | 0.705394 | 3 | 0 | 3 |
| ROBO2 | CCL13 | 0.702646 | 3 | 0 | 3 |
| ROBO2 | ZNF682 | 0.696953 | 4 | 0 | 4 |
| ROBO2 | TMPRSS11A | 0.687805 | 3 | 0 | 3 |
| ROBO2 | PDZRN3 | 0.68506 | 6 | 0 | 6 |
| ROBO2 | GALNT9 | 0.684681 | 3 | 0 | 3 |
| ROBO2 | DAPL1 | 0.681454 | 5 | 0 | 5 |
| ROBO2 | CAPN14 | 0.679984 | 6 | 0 | 6 |
| ROBO2 | SPAG17 | 0.677662 | 4 | 0 | 4 |
| ROBO2 | BNIPL | 0.677317 | 5 | 0 | 5 |
| ROBO2 | PTN | 0.677128 | 5 | 0 | 4 |
| ROBO2 | CYB5D2 | 0.676716 | 4 | 0 | 4 |
| ROBO2 | MUC15 | 0.676252 | 6 | 0 | 5 |
| ROBO2 | ANKRD35 | 0.675367 | 7 | 0 | 6 |
| ROBO2 | SCN3A | 0.67445 | 3 | 0 | 3 |
| ROBO2 | FAM219B | 0.672382 | 5 | 0 | 5 |
| ROBO2 | TNNI3K | 0.672346 | 3 | 0 | 3 |
| ROBO2 | SASH1 | 0.670965 | 7 | 0 | 7 |
| ROBO2 | GCHFR | 0.666573 | 5 | 0 | 5 |
For details and further investigation, click here
