| Full name: betacellulin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 685 | HGNC ID: HGNC:1121 | Ensembl Gene: ENSG00000174808 | OMIM ID: 600345 |
| Drug and gene relationship at DGIdb | |||
BTC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway |
Expression of BTC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BTC | 685 | 241412_at | -2.6705 | 0.0768 | |
| GSE20347 | BTC | 685 | 207326_at | -0.3584 | 0.0000 | |
| GSE23400 | BTC | 685 | 207326_at | -0.1633 | 0.0000 | |
| GSE26886 | BTC | 685 | 241412_at | -1.9185 | 0.0007 | |
| GSE29001 | BTC | 685 | 207326_at | -0.1262 | 0.5620 | |
| GSE38129 | BTC | 685 | 207326_at | -0.5640 | 0.0005 | |
| GSE45670 | BTC | 685 | 241412_at | -2.7499 | 0.0000 | |
| GSE53622 | BTC | 685 | 111094 | -1.7942 | 0.0000 | |
| GSE53624 | BTC | 685 | 111094 | -1.7544 | 0.0000 | |
| GSE63941 | BTC | 685 | 207326_at | 0.5317 | 0.3723 | |
| GSE77861 | BTC | 685 | 241412_at | -0.7643 | 0.0206 | |
| GSE97050 | BTC | 685 | A_23_P135722 | -1.2447 | 0.1729 | |
| SRP007169 | BTC | 685 | RNAseq | -3.3195 | 0.0000 | |
| SRP008496 | BTC | 685 | RNAseq | -1.9800 | 0.0002 | |
| SRP064894 | BTC | 685 | RNAseq | -0.9671 | 0.0083 | |
| SRP133303 | BTC | 685 | RNAseq | -0.4250 | 0.4499 | |
| SRP159526 | BTC | 685 | RNAseq | -1.7674 | 0.0008 | |
| SRP193095 | BTC | 685 | RNAseq | -1.6204 | 0.0000 | |
| SRP219564 | BTC | 685 | RNAseq | -1.2594 | 0.1532 | |
| TCGA | BTC | 685 | RNAseq | -1.0603 | 0.0029 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by BTC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BTC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BTC | 685 | 2 | 9 | 19 | |
| GSE20123 | BTC | 685 | 2 | 9 | 19 | |
| GSE43470 | BTC | 685 | 0 | 13 | 30 | |
| GSE46452 | BTC | 685 | 3 | 34 | 22 | |
| GSE47630 | BTC | 685 | 1 | 19 | 20 | |
| GSE54993 | BTC | 685 | 7 | 0 | 63 | |
| GSE54994 | BTC | 685 | 1 | 9 | 43 | |
| GSE60625 | BTC | 685 | 0 | 0 | 11 | |
| GSE74703 | BTC | 685 | 0 | 11 | 25 | |
| GSE74704 | BTC | 685 | 2 | 5 | 13 | |
| TCGA | BTC | 685 | 17 | 28 | 51 |
Total number of gains: 35; Total number of losses: 137; Total Number of normals: 316.
Somatic mutations of BTC:
Generating mutation plots.
Highly correlated genes for BTC:
Showing top 20/1252 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BTC | NEGR1 | 0.818413 | 5 | 0 | 5 |
| BTC | RBFOX3 | 0.803664 | 3 | 0 | 3 |
| BTC | ANGPTL1 | 0.798659 | 5 | 0 | 5 |
| BTC | MYOM1 | 0.780899 | 8 | 0 | 7 |
| BTC | CYP21A2 | 0.774596 | 3 | 0 | 3 |
| BTC | C14orf28 | 0.774204 | 6 | 0 | 6 |
| BTC | KCNMB1 | 0.773212 | 7 | 0 | 7 |
| BTC | SLITRK3 | 0.772883 | 7 | 0 | 7 |
| BTC | ATP1A2 | 0.769904 | 8 | 0 | 7 |
| BTC | MYZAP | 0.767167 | 3 | 0 | 3 |
| BTC | EIF4E3 | 0.766185 | 7 | 0 | 7 |
| BTC | RNF150 | 0.764642 | 5 | 0 | 5 |
| BTC | EPM2A | 0.75954 | 5 | 0 | 5 |
| BTC | COBL | 0.759316 | 10 | 0 | 10 |
| BTC | LMOD1 | 0.756138 | 8 | 0 | 7 |
| BTC | ANO5 | 0.752732 | 5 | 0 | 5 |
| BTC | VMAC | 0.752285 | 3 | 0 | 3 |
| BTC | FXYD1 | 0.751838 | 6 | 0 | 5 |
| BTC | PLP1 | 0.750265 | 8 | 0 | 8 |
| BTC | SCN7A | 0.74927 | 8 | 0 | 7 |
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