| Full name: troponin T2, cardiac type | Alias Symbol: CMPD2 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 7139 | HGNC ID: HGNC:11949 | Ensembl Gene: ENSG00000118194 | OMIM ID: 191045 |
| Drug and gene relationship at DGIdb | |||
TNNT2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of TNNT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNT2 | 7139 | 215389_s_at | 0.1162 | 0.7612 | |
| GSE20347 | TNNT2 | 7139 | 215389_s_at | -0.1173 | 0.4576 | |
| GSE23400 | TNNT2 | 7139 | 215389_s_at | -0.0191 | 0.7046 | |
| GSE26886 | TNNT2 | 7139 | 215389_s_at | 0.0131 | 0.9620 | |
| GSE29001 | TNNT2 | 7139 | 215389_s_at | 0.0270 | 0.9545 | |
| GSE38129 | TNNT2 | 7139 | 215389_s_at | 0.0293 | 0.8457 | |
| GSE45670 | TNNT2 | 7139 | 215389_s_at | 0.0570 | 0.8243 | |
| GSE53622 | TNNT2 | 7139 | 11184 | -0.1966 | 0.0198 | |
| GSE53624 | TNNT2 | 7139 | 11184 | -0.5878 | 0.0000 | |
| GSE63941 | TNNT2 | 7139 | 1563655_at | 0.3974 | 0.0008 | |
| GSE77861 | TNNT2 | 7139 | 215389_s_at | 0.0165 | 0.9361 | |
| GSE97050 | TNNT2 | 7139 | A_23_P34700 | -0.2538 | 0.2290 | |
| SRP064894 | TNNT2 | 7139 | RNAseq | -0.5273 | 0.1962 | |
| SRP133303 | TNNT2 | 7139 | RNAseq | -0.6492 | 0.0544 | |
| SRP159526 | TNNT2 | 7139 | RNAseq | 0.3804 | 0.4604 | |
| SRP219564 | TNNT2 | 7139 | RNAseq | 0.1632 | 0.8464 | |
| TCGA | TNNT2 | 7139 | RNAseq | 1.0985 | 0.0088 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TNNT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNNT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNT2 | 7139 | 11 | 0 | 19 | |
| GSE20123 | TNNT2 | 7139 | 11 | 0 | 19 | |
| GSE43470 | TNNT2 | 7139 | 6 | 0 | 37 | |
| GSE46452 | TNNT2 | 7139 | 3 | 1 | 55 | |
| GSE47630 | TNNT2 | 7139 | 14 | 0 | 26 | |
| GSE54993 | TNNT2 | 7139 | 0 | 6 | 64 | |
| GSE54994 | TNNT2 | 7139 | 15 | 0 | 38 | |
| GSE60625 | TNNT2 | 7139 | 0 | 0 | 11 | |
| GSE74703 | TNNT2 | 7139 | 6 | 0 | 30 | |
| GSE74704 | TNNT2 | 7139 | 5 | 0 | 15 | |
| TCGA | TNNT2 | 7139 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of TNNT2:
Generating mutation plots.
Highly correlated genes for TNNT2:
Showing top 20/105 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNT2 | BARHL2 | 0.782607 | 3 | 0 | 3 |
| TNNT2 | DMC1 | 0.744883 | 3 | 0 | 3 |
| TNNT2 | ZNF497 | 0.740372 | 3 | 0 | 3 |
| TNNT2 | RHBDL1 | 0.735844 | 3 | 0 | 3 |
| TNNT2 | OR13G1 | 0.728783 | 3 | 0 | 3 |
| TNNT2 | MAP7D2 | 0.725212 | 3 | 0 | 3 |
| TNNT2 | GALK2 | 0.709679 | 3 | 0 | 3 |
| TNNT2 | SBNO2 | 0.706433 | 3 | 0 | 3 |
| TNNT2 | FTMT | 0.705344 | 3 | 0 | 3 |
| TNNT2 | LCE1A | 0.704446 | 3 | 0 | 3 |
| TNNT2 | SCNN1D | 0.696123 | 4 | 0 | 3 |
| TNNT2 | TPRX1 | 0.688758 | 3 | 0 | 3 |
| TNNT2 | UQCRC1 | 0.684071 | 3 | 0 | 3 |
| TNNT2 | NT5C1A | 0.683881 | 3 | 0 | 3 |
| TNNT2 | ZFPM1 | 0.683853 | 3 | 0 | 3 |
| TNNT2 | KRTAP4-1 | 0.682937 | 3 | 0 | 3 |
| TNNT2 | CAPN10 | 0.682734 | 4 | 0 | 3 |
| TNNT2 | TTC7A | 0.680749 | 4 | 0 | 4 |
| TNNT2 | TNR | 0.675982 | 4 | 0 | 3 |
| TNNT2 | GRIK4 | 0.668765 | 3 | 0 | 3 |
For details and further investigation, click here
