| Full name: ubiquinol-cytochrome c reductase core protein 1 | Alias Symbol: D3S3191|QCR1|UQCR1 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 7384 | HGNC ID: HGNC:12585 | Ensembl Gene: ENSG00000010256 | OMIM ID: 191328 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of UQCRC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UQCRC1 | 7384 | 201903_at | 0.2590 | 0.3586 | |
| GSE20347 | UQCRC1 | 7384 | 201903_at | -0.3695 | 0.0119 | |
| GSE23400 | UQCRC1 | 7384 | 201903_at | -0.0203 | 0.7336 | |
| GSE26886 | UQCRC1 | 7384 | 201903_at | -0.7395 | 0.0002 | |
| GSE29001 | UQCRC1 | 7384 | 201903_at | -0.4000 | 0.3588 | |
| GSE38129 | UQCRC1 | 7384 | 201903_at | -0.2597 | 0.0355 | |
| GSE45670 | UQCRC1 | 7384 | 201903_at | 0.1193 | 0.3463 | |
| GSE53622 | UQCRC1 | 7384 | 10794 | -0.4100 | 0.0000 | |
| GSE53624 | UQCRC1 | 7384 | 10794 | -0.1145 | 0.0680 | |
| GSE63941 | UQCRC1 | 7384 | 201903_at | 1.9325 | 0.0000 | |
| GSE77861 | UQCRC1 | 7384 | 201903_at | -0.0752 | 0.7321 | |
| GSE97050 | UQCRC1 | 7384 | A_23_P132675 | -0.1826 | 0.4785 | |
| SRP007169 | UQCRC1 | 7384 | RNAseq | -0.5121 | 0.1215 | |
| SRP008496 | UQCRC1 | 7384 | RNAseq | -0.6222 | 0.0001 | |
| SRP064894 | UQCRC1 | 7384 | RNAseq | 0.0802 | 0.7246 | |
| SRP133303 | UQCRC1 | 7384 | RNAseq | -0.0910 | 0.5996 | |
| SRP159526 | UQCRC1 | 7384 | RNAseq | -0.0223 | 0.9377 | |
| SRP193095 | UQCRC1 | 7384 | RNAseq | -0.5194 | 0.0001 | |
| SRP219564 | UQCRC1 | 7384 | RNAseq | -0.2221 | 0.6261 | |
| TCGA | UQCRC1 | 7384 | RNAseq | -0.1803 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by UQCRC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UQCRC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UQCRC1 | 7384 | 0 | 18 | 12 | |
| GSE20123 | UQCRC1 | 7384 | 0 | 19 | 11 | |
| GSE43470 | UQCRC1 | 7384 | 0 | 19 | 24 | |
| GSE46452 | UQCRC1 | 7384 | 3 | 16 | 40 | |
| GSE47630 | UQCRC1 | 7384 | 1 | 24 | 15 | |
| GSE54993 | UQCRC1 | 7384 | 6 | 2 | 62 | |
| GSE54994 | UQCRC1 | 7384 | 0 | 36 | 17 | |
| GSE60625 | UQCRC1 | 7384 | 5 | 0 | 6 | |
| GSE74703 | UQCRC1 | 7384 | 0 | 15 | 21 | |
| GSE74704 | UQCRC1 | 7384 | 0 | 12 | 8 | |
| TCGA | UQCRC1 | 7384 | 0 | 78 | 18 |
Total number of gains: 15; Total number of losses: 239; Total Number of normals: 234.
Somatic mutations of UQCRC1:
Generating mutation plots.
Highly correlated genes for UQCRC1:
Showing top 20/134 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UQCRC1 | PAFAH2 | 0.808896 | 3 | 0 | 3 |
| UQCRC1 | DNAJB8 | 0.72699 | 3 | 0 | 3 |
| UQCRC1 | ZNF687 | 0.721921 | 3 | 0 | 3 |
| UQCRC1 | KRT15 | 0.694369 | 3 | 0 | 3 |
| UQCRC1 | PHGR1 | 0.692933 | 3 | 0 | 3 |
| UQCRC1 | TNNT2 | 0.684071 | 3 | 0 | 3 |
| UQCRC1 | MBP | 0.681331 | 3 | 0 | 3 |
| UQCRC1 | ATP6V0A1 | 0.6677 | 3 | 0 | 3 |
| UQCRC1 | PYGO2 | 0.66477 | 4 | 0 | 3 |
| UQCRC1 | CCDC88C | 0.663941 | 3 | 0 | 3 |
| UQCRC1 | MOB2 | 0.659628 | 5 | 0 | 4 |
| UQCRC1 | UBXN6 | 0.659577 | 4 | 0 | 3 |
| UQCRC1 | CHTF8 | 0.656642 | 5 | 0 | 5 |
| UQCRC1 | WNK2 | 0.656334 | 4 | 0 | 3 |
| UQCRC1 | FBXO24 | 0.654173 | 4 | 0 | 4 |
| UQCRC1 | DSP | 0.653469 | 4 | 0 | 3 |
| UQCRC1 | TRIM29 | 0.651541 | 5 | 0 | 4 |
| UQCRC1 | MTUS2 | 0.650543 | 3 | 0 | 3 |
| UQCRC1 | LDHC | 0.649077 | 3 | 0 | 3 |
| UQCRC1 | UMODL1 | 0.647099 | 4 | 0 | 3 |
For details and further investigation, click here
