| Full name: late cornified envelope 1A | Alias Symbol: LEP1 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 353131 | HGNC ID: HGNC:29459 | Ensembl Gene: ENSG00000186844 | OMIM ID: 612603 |
| Drug and gene relationship at DGIdb | |||
Expression of LCE1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | LCE1A | 353131 | 83316 | -0.3484 | 0.0016 | |
| GSE53624 | LCE1A | 353131 | 83316 | -0.1978 | 0.0895 | |
| GSE97050 | LCE1A | 353131 | A_23_P404685 | 0.5060 | 0.1270 | |
| TCGA | LCE1A | 353131 | RNAseq | 1.9908 | 0.2461 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LCE1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCE1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCE1A | 353131 | 15 | 0 | 15 | |
| GSE20123 | LCE1A | 353131 | 15 | 0 | 15 | |
| GSE43470 | LCE1A | 353131 | 6 | 2 | 35 | |
| GSE46452 | LCE1A | 353131 | 3 | 1 | 55 | |
| GSE47630 | LCE1A | 353131 | 15 | 0 | 25 | |
| GSE54993 | LCE1A | 353131 | 0 | 4 | 66 | |
| GSE54994 | LCE1A | 353131 | 15 | 0 | 38 | |
| GSE60625 | LCE1A | 353131 | 0 | 0 | 11 | |
| GSE74703 | LCE1A | 353131 | 6 | 1 | 29 | |
| GSE74704 | LCE1A | 353131 | 7 | 0 | 13 | |
| TCGA | LCE1A | 353131 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of LCE1A:
Generating mutation plots.
Highly correlated genes for LCE1A:
Showing top 20/21 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCE1A | TNP1 | 0.716499 | 3 | 0 | 3 |
| LCE1A | PHOSPHO1 | 0.709181 | 3 | 0 | 3 |
| LCE1A | TNNT2 | 0.704446 | 3 | 0 | 3 |
| LCE1A | COL20A1 | 0.690894 | 3 | 0 | 3 |
| LCE1A | KCNA7 | 0.682697 | 3 | 0 | 3 |
| LCE1A | C8G | 0.680079 | 3 | 0 | 3 |
| LCE1A | MGAT5B | 0.676686 | 3 | 0 | 3 |
| LCE1A | THPO | 0.672651 | 3 | 0 | 3 |
| LCE1A | SCNN1D | 0.67242 | 3 | 0 | 3 |
| LCE1A | OR10G3 | 0.663449 | 3 | 0 | 3 |
| LCE1A | FSCN2 | 0.65947 | 3 | 0 | 3 |
| LCE1A | KRTAP19-1 | 0.644595 | 3 | 0 | 3 |
| LCE1A | RAD51D | 0.642117 | 3 | 0 | 3 |
| LCE1A | NKX2-3 | 0.641252 | 3 | 0 | 3 |
| LCE1A | PSPN | 0.638924 | 3 | 0 | 3 |
| LCE1A | FXYD2 | 0.638001 | 3 | 0 | 3 |
| LCE1A | RUFY4 | 0.618053 | 3 | 0 | 3 |
| LCE1A | PLCH2 | 0.61349 | 3 | 0 | 3 |
| LCE1A | KBTBD13 | 0.608087 | 3 | 0 | 3 |
| LCE1A | GHRHR | 0.606467 | 4 | 0 | 3 |
For details and further investigation, click here
