| Full name: N-ribosyldihydronicotinamide:quinone reductase 2 | Alias Symbol: QR2|DHQV|DIA6 | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 4835 | HGNC ID: HGNC:7856 | Ensembl Gene: ENSG00000124588 | OMIM ID: 160998 |
| Drug and gene relationship at DGIdb | |||
Expression of NQO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NQO2 | 4835 | 203814_s_at | 0.5794 | 0.2701 | |
| GSE20347 | NQO2 | 4835 | 203814_s_at | -0.2174 | 0.4430 | |
| GSE23400 | NQO2 | 4835 | 203814_s_at | 0.1646 | 0.2176 | |
| GSE26886 | NQO2 | 4835 | 203814_s_at | 0.4696 | 0.0634 | |
| GSE29001 | NQO2 | 4835 | 203814_s_at | -0.3249 | 0.5220 | |
| GSE38129 | NQO2 | 4835 | 203814_s_at | -0.2182 | 0.2852 | |
| GSE45670 | NQO2 | 4835 | 203814_s_at | 0.1806 | 0.5335 | |
| GSE53622 | NQO2 | 4835 | 291 | 0.6216 | 0.0000 | |
| GSE53624 | NQO2 | 4835 | 291 | 0.3644 | 0.0000 | |
| GSE63941 | NQO2 | 4835 | 203814_s_at | -1.1382 | 0.1623 | |
| GSE77861 | NQO2 | 4835 | 203814_s_at | 0.3937 | 0.4968 | |
| GSE97050 | NQO2 | 4835 | A_23_P58953 | -0.0144 | 0.9481 | |
| SRP007169 | NQO2 | 4835 | RNAseq | 1.0712 | 0.0867 | |
| SRP008496 | NQO2 | 4835 | RNAseq | 1.5233 | 0.0087 | |
| SRP064894 | NQO2 | 4835 | RNAseq | 0.2719 | 0.2830 | |
| SRP133303 | NQO2 | 4835 | RNAseq | -0.1365 | 0.7233 | |
| SRP159526 | NQO2 | 4835 | RNAseq | 0.3895 | 0.1388 | |
| SRP193095 | NQO2 | 4835 | RNAseq | 0.3262 | 0.1240 | |
| SRP219564 | NQO2 | 4835 | RNAseq | 0.0705 | 0.7897 | |
| TCGA | NQO2 | 4835 | RNAseq | 0.0210 | 0.8238 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NQO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NQO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NQO2 | 4835 | 4 | 5 | 21 | |
| GSE20123 | NQO2 | 4835 | 4 | 5 | 21 | |
| GSE43470 | NQO2 | 4835 | 8 | 4 | 31 | |
| GSE46452 | NQO2 | 4835 | 1 | 10 | 48 | |
| GSE47630 | NQO2 | 4835 | 7 | 8 | 25 | |
| GSE54993 | NQO2 | 4835 | 1 | 1 | 68 | |
| GSE54994 | NQO2 | 4835 | 10 | 3 | 40 | |
| GSE60625 | NQO2 | 4835 | 0 | 1 | 10 | |
| GSE74703 | NQO2 | 4835 | 7 | 3 | 26 | |
| GSE74704 | NQO2 | 4835 | 2 | 2 | 16 | |
| TCGA | NQO2 | 4835 | 17 | 30 | 49 |
Total number of gains: 61; Total number of losses: 72; Total Number of normals: 355.
Somatic mutations of NQO2:
Generating mutation plots.
Highly correlated genes for NQO2:
Showing top 20/168 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NQO2 | ALG11 | 0.866076 | 3 | 0 | 3 |
| NQO2 | GRIA4 | 0.796136 | 3 | 0 | 3 |
| NQO2 | GTF2E1 | 0.7943 | 3 | 0 | 3 |
| NQO2 | ASB3 | 0.791405 | 3 | 0 | 3 |
| NQO2 | KRTAP12-2 | 0.787751 | 3 | 0 | 3 |
| NQO2 | CCDC154 | 0.770487 | 3 | 0 | 3 |
| NQO2 | NEK11 | 0.765384 | 3 | 0 | 3 |
| NQO2 | CENPL | 0.762706 | 3 | 0 | 3 |
| NQO2 | TMEM209 | 0.760757 | 3 | 0 | 3 |
| NQO2 | TP53AIP1 | 0.744222 | 3 | 0 | 3 |
| NQO2 | RBM17 | 0.741903 | 4 | 0 | 4 |
| NQO2 | OR2T33 | 0.73409 | 3 | 0 | 3 |
| NQO2 | C1orf112 | 0.729164 | 3 | 0 | 3 |
| NQO2 | CPSF6 | 0.724521 | 3 | 0 | 3 |
| NQO2 | DDHD1 | 0.721839 | 3 | 0 | 3 |
| NQO2 | TMEM150A | 0.71814 | 3 | 0 | 3 |
| NQO2 | DTX4 | 0.714391 | 3 | 0 | 3 |
| NQO2 | LANCL2 | 0.714005 | 3 | 0 | 3 |
| NQO2 | LINC00355 | 0.711768 | 4 | 0 | 4 |
| NQO2 | FCHSD2 | 0.711752 | 3 | 0 | 3 |
For details and further investigation, click here
