| Full name: DENN domain containing 1B | Alias Symbol: MGC27044|FLJ20054 | ||
| Type: protein-coding gene | Cytoband: 1q31.3 | ||
| Entrez ID: 163486 | HGNC ID: HGNC:28404 | Ensembl Gene: ENSG00000213047 | OMIM ID: 613292 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND1B | 163486 | 219696_at | 0.1960 | 0.8075 | |
| GSE20347 | DENND1B | 163486 | 219696_at | -0.9659 | 0.0001 | |
| GSE23400 | DENND1B | 163486 | 219696_at | -0.2663 | 0.0100 | |
| GSE26886 | DENND1B | 163486 | 219696_at | -0.0202 | 0.9705 | |
| GSE29001 | DENND1B | 163486 | 219696_at | -0.3849 | 0.5716 | |
| GSE38129 | DENND1B | 163486 | 219696_at | -0.5993 | 0.0447 | |
| GSE45670 | DENND1B | 163486 | 219696_at | 0.1582 | 0.4441 | |
| GSE53622 | DENND1B | 163486 | 54192 | -0.1938 | 0.0586 | |
| GSE53624 | DENND1B | 163486 | 7671 | -0.6539 | 0.0000 | |
| GSE63941 | DENND1B | 163486 | 219696_at | 1.1135 | 0.0496 | |
| GSE77861 | DENND1B | 163486 | 219696_at | 0.0328 | 0.9222 | |
| GSE97050 | DENND1B | 163486 | A_23_P201605 | 0.2693 | 0.3978 | |
| SRP007169 | DENND1B | 163486 | RNAseq | -1.8346 | 0.0000 | |
| SRP008496 | DENND1B | 163486 | RNAseq | -1.2228 | 0.0000 | |
| SRP064894 | DENND1B | 163486 | RNAseq | -0.6129 | 0.0077 | |
| SRP133303 | DENND1B | 163486 | RNAseq | -0.0436 | 0.8014 | |
| SRP159526 | DENND1B | 163486 | RNAseq | -0.3502 | 0.3711 | |
| SRP193095 | DENND1B | 163486 | RNAseq | -0.5806 | 0.0001 | |
| SRP219564 | DENND1B | 163486 | RNAseq | -0.2103 | 0.7038 | |
| TCGA | DENND1B | 163486 | RNAseq | 0.0270 | 0.7800 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by DENND1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND1B | 163486 | 7 | 0 | 23 | |
| GSE20123 | DENND1B | 163486 | 7 | 0 | 23 | |
| GSE43470 | DENND1B | 163486 | 6 | 1 | 36 | |
| GSE46452 | DENND1B | 163486 | 3 | 1 | 55 | |
| GSE47630 | DENND1B | 163486 | 14 | 0 | 26 | |
| GSE54993 | DENND1B | 163486 | 0 | 6 | 64 | |
| GSE54994 | DENND1B | 163486 | 16 | 0 | 37 | |
| GSE60625 | DENND1B | 163486 | 0 | 0 | 11 | |
| GSE74703 | DENND1B | 163486 | 6 | 1 | 29 | |
| GSE74704 | DENND1B | 163486 | 2 | 0 | 18 | |
| TCGA | DENND1B | 163486 | 41 | 6 | 49 |
Total number of gains: 102; Total number of losses: 15; Total Number of normals: 371.
Somatic mutations of DENND1B:
Generating mutation plots.
Highly correlated genes for DENND1B:
Showing top 20/762 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND1B | DDX52 | 0.824353 | 3 | 0 | 3 |
| DENND1B | TPP2 | 0.769504 | 3 | 0 | 3 |
| DENND1B | CCIN | 0.760888 | 3 | 0 | 3 |
| DENND1B | ZNF195 | 0.75992 | 3 | 0 | 3 |
| DENND1B | GOLGA5 | 0.74441 | 4 | 0 | 4 |
| DENND1B | TP53AIP1 | 0.744193 | 3 | 0 | 3 |
| DENND1B | C3orf38 | 0.740235 | 3 | 0 | 3 |
| DENND1B | HSDL2 | 0.73508 | 3 | 0 | 3 |
| DENND1B | CHD2 | 0.733576 | 3 | 0 | 3 |
| DENND1B | RCOR3 | 0.733457 | 3 | 0 | 3 |
| DENND1B | PPHLN1 | 0.731916 | 3 | 0 | 3 |
| DENND1B | PANK3 | 0.731167 | 5 | 0 | 5 |
| DENND1B | F12 | 0.729934 | 4 | 0 | 4 |
| DENND1B | FAM200A | 0.726026 | 3 | 0 | 3 |
| DENND1B | ECD | 0.717031 | 3 | 0 | 3 |
| DENND1B | HTATIP2 | 0.71691 | 3 | 0 | 3 |
| DENND1B | NAV2 | 0.713838 | 3 | 0 | 3 |
| DENND1B | C1orf43 | 0.709936 | 3 | 0 | 3 |
| DENND1B | SOS1 | 0.703705 | 3 | 0 | 3 |
| DENND1B | BAG4 | 0.703349 | 3 | 0 | 3 |
For details and further investigation, click here
