| Full name: heat shock protein family A (Hsp70) member 4 | Alias Symbol: HS24/P52|HSPH2 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 3308 | HGNC ID: HGNC:5237 | Ensembl Gene: ENSG00000170606 | OMIM ID: 601113 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HSPA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPA4 | 3308 | 211015_s_at | -0.0844 | 0.9297 | |
| GSE20347 | HSPA4 | 3308 | 208815_x_at | -0.4898 | 0.0075 | |
| GSE23400 | HSPA4 | 3308 | 208815_x_at | -0.3885 | 0.0001 | |
| GSE26886 | HSPA4 | 3308 | 208815_x_at | -0.4583 | 0.0253 | |
| GSE29001 | HSPA4 | 3308 | 208815_x_at | -0.6473 | 0.1173 | |
| GSE38129 | HSPA4 | 3308 | 208815_x_at | -0.0493 | 0.8194 | |
| GSE45670 | HSPA4 | 3308 | 208815_x_at | 0.0596 | 0.8210 | |
| GSE53622 | HSPA4 | 3308 | 73834 | -0.3552 | 0.0000 | |
| GSE53624 | HSPA4 | 3308 | 73834 | -0.3290 | 0.0000 | |
| GSE63941 | HSPA4 | 3308 | 208815_x_at | -0.1924 | 0.7253 | |
| GSE77861 | HSPA4 | 3308 | 208815_x_at | -0.4406 | 0.1589 | |
| GSE97050 | HSPA4 | 3308 | A_24_P377277 | -0.2035 | 0.5091 | |
| SRP007169 | HSPA4 | 3308 | RNAseq | -0.5262 | 0.2520 | |
| SRP008496 | HSPA4 | 3308 | RNAseq | -0.6166 | 0.0260 | |
| SRP064894 | HSPA4 | 3308 | RNAseq | -0.6147 | 0.0001 | |
| SRP133303 | HSPA4 | 3308 | RNAseq | -0.1583 | 0.3639 | |
| SRP159526 | HSPA4 | 3308 | RNAseq | -0.3373 | 0.3459 | |
| SRP193095 | HSPA4 | 3308 | RNAseq | -0.5957 | 0.0000 | |
| SRP219564 | HSPA4 | 3308 | RNAseq | -0.7020 | 0.0281 | |
| TCGA | HSPA4 | 3308 | RNAseq | 0.0900 | 0.0522 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSPA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPA4 | 3308 | 1 | 11 | 18 | |
| GSE20123 | HSPA4 | 3308 | 2 | 11 | 17 | |
| GSE43470 | HSPA4 | 3308 | 2 | 9 | 32 | |
| GSE46452 | HSPA4 | 3308 | 0 | 27 | 32 | |
| GSE47630 | HSPA4 | 3308 | 0 | 21 | 19 | |
| GSE54993 | HSPA4 | 3308 | 9 | 1 | 60 | |
| GSE54994 | HSPA4 | 3308 | 2 | 16 | 35 | |
| GSE60625 | HSPA4 | 3308 | 0 | 0 | 11 | |
| GSE74703 | HSPA4 | 3308 | 2 | 6 | 28 | |
| GSE74704 | HSPA4 | 3308 | 1 | 5 | 14 | |
| TCGA | HSPA4 | 3308 | 3 | 38 | 55 |
Total number of gains: 22; Total number of losses: 145; Total Number of normals: 321.
Somatic mutations of HSPA4:
Generating mutation plots.
Highly correlated genes for HSPA4:
Showing top 20/1084 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPA4 | SCRN3 | 0.799525 | 3 | 0 | 3 |
| HSPA4 | TP53AIP1 | 0.788534 | 3 | 0 | 3 |
| HSPA4 | FAM122A | 0.782978 | 3 | 0 | 3 |
| HSPA4 | PPIP5K2 | 0.782212 | 4 | 0 | 4 |
| HSPA4 | C16orf72 | 0.772133 | 3 | 0 | 3 |
| HSPA4 | HDHD2 | 0.762377 | 3 | 0 | 3 |
| HSPA4 | MRPL30 | 0.749794 | 3 | 0 | 3 |
| HSPA4 | UGP2 | 0.749065 | 4 | 0 | 4 |
| HSPA4 | ARRDC3 | 0.746134 | 3 | 0 | 3 |
| HSPA4 | RANBP6 | 0.740015 | 3 | 0 | 3 |
| HSPA4 | PPM1D | 0.735389 | 3 | 0 | 3 |
| HSPA4 | NOXO1 | 0.733114 | 3 | 0 | 3 |
| HSPA4 | NIPBL | 0.732957 | 3 | 0 | 3 |
| HSPA4 | SLC4A1AP | 0.73207 | 3 | 0 | 3 |
| HSPA4 | DYNC1LI2 | 0.722709 | 3 | 0 | 3 |
| HSPA4 | EBPL | 0.721763 | 3 | 0 | 3 |
| HSPA4 | ZNF91 | 0.721218 | 3 | 0 | 3 |
| HSPA4 | COG6 | 0.715666 | 3 | 0 | 3 |
| HSPA4 | PPP2CA | 0.714912 | 13 | 0 | 12 |
| HSPA4 | GSKIP | 0.7127 | 5 | 0 | 5 |
For details and further investigation, click here
