TRABD2B

 

Full name: TraB domain containing 2B Alias Symbol: TIKI2
Type: protein-coding gene Cytoband: 1p33
Entrez ID: 388630 HGNC ID: HGNC:44200 Ensembl Gene: ENSG00000269113 OMIM ID: 614913
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TRABD2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TRABD2B 388630 241707_at -0.2665 0.3115
GSE26886 TRABD2B 388630 241707_at 0.0107 0.9358
GSE45670 TRABD2B 388630 241707_at 0.0017 0.9903
GSE53622 TRABD2B 388630 1443 -0.7466 0.0000
GSE53624 TRABD2B 388630 1443 -0.1400 0.0571
GSE63941 TRABD2B 388630 241707_at 0.0294 0.8694
GSE77861 TRABD2B 388630 241707_at -0.0356 0.8383
SRP133303 TRABD2B 388630 RNAseq -1.2274 0.0018
SRP159526 TRABD2B 388630 RNAseq -0.4741 0.4311
SRP219564 TRABD2B 388630 RNAseq 0.3193 0.5899

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by TRABD2B expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  


Copy number change of TRABD2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TRABD2B 388630 3 3 24
GSE20123 TRABD2B 388630 3 2 25
GSE43470 TRABD2B 388630 4 3 36
GSE46452 TRABD2B 388630 2 1 56
GSE47630 TRABD2B 388630 8 4 28
GSE54993 TRABD2B 388630 0 1 69
GSE54994 TRABD2B 388630 11 2 40
GSE60625 TRABD2B 388630 0 0 11
GSE74703 TRABD2B 388630 3 2 31
GSE74704 TRABD2B 388630 2 0 18
TCGA TRABD2B 388630 10 17 69

Total number of gains: 46; Total number of losses: 35; Total Number of normals: 407.  


 

Somatic mutations of TRABD2B:

 

Generating mutation plots.

 

Highly correlated genes for TRABD2B:

 

Showing top 20/69 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TRABD2BTMEM106A0.681641303
TRABD2BMPL0.664147303
TRABD2BLINC006280.646244303
TRABD2BF100.639746303
TRABD2BTAL10.63535303
TRABD2BZGLP10.621681303
TRABD2BDPT0.619791303
TRABD2BPLEKHB10.616799303
TRABD2BIQCJ-SCHIP1-AS10.616049403
TRABD2BZMYND100.614505303
TRABD2BKCTD100.614176303
TRABD2BC10orf670.612392303
TRABD2BDNAH90.605506303
TRABD2BCDRT150.604386303
TRABD2BCMA10.596999403
TRABD2BSLC25A470.594589403
TRABD2BADAMTS9-AS20.588607303
TRABD2BLELP10.587212403
TRABD2BTPSD10.586226404
TRABD2BLDB30.582565403

For details and further investigation, click here