| Full name: MPL proto-oncogene, thrombopoietin receptor | Alias Symbol: CD110|TPOR|THPOR | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 4352 | HGNC ID: HGNC:7217 | Ensembl Gene: ENSG00000117400 | OMIM ID: 159530 |
| Drug and gene relationship at DGIdb | |||
MPL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of MPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPL | 4352 | 207550_at | -0.8944 | 0.0621 | |
| GSE20347 | MPL | 4352 | 216825_s_at | -0.0166 | 0.8573 | |
| GSE23400 | MPL | 4352 | 216825_s_at | -0.1751 | 0.0001 | |
| GSE26886 | MPL | 4352 | 211903_s_at | 0.3461 | 0.0188 | |
| GSE29001 | MPL | 4352 | 216825_s_at | -0.1791 | 0.4595 | |
| GSE38129 | MPL | 4352 | 216825_s_at | -0.0687 | 0.3021 | |
| GSE45670 | MPL | 4352 | 211903_s_at | -0.0568 | 0.5897 | |
| GSE53622 | MPL | 4352 | 103459 | 0.5538 | 0.0001 | |
| GSE53624 | MPL | 4352 | 103459 | 0.7045 | 0.0001 | |
| GSE63941 | MPL | 4352 | 211903_s_at | 0.2023 | 0.2569 | |
| GSE77861 | MPL | 4352 | 211903_s_at | -0.2432 | 0.1647 | |
| GSE97050 | MPL | 4352 | A_33_P3325897 | 0.4724 | 0.2151 | |
| SRP064894 | MPL | 4352 | RNAseq | 0.1115 | 0.6198 | |
| SRP133303 | MPL | 4352 | RNAseq | 0.0286 | 0.8479 | |
| SRP159526 | MPL | 4352 | RNAseq | 0.7744 | 0.2456 | |
| SRP193095 | MPL | 4352 | RNAseq | 0.0658 | 0.6759 | |
| SRP219564 | MPL | 4352 | RNAseq | -0.1560 | 0.6942 | |
| TCGA | MPL | 4352 | RNAseq | -0.5424 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPL | 4352 | 4 | 3 | 23 | |
| GSE20123 | MPL | 4352 | 4 | 2 | 24 | |
| GSE43470 | MPL | 4352 | 7 | 2 | 34 | |
| GSE46452 | MPL | 4352 | 3 | 1 | 55 | |
| GSE47630 | MPL | 4352 | 9 | 2 | 29 | |
| GSE54993 | MPL | 4352 | 0 | 2 | 68 | |
| GSE54994 | MPL | 4352 | 13 | 2 | 38 | |
| GSE60625 | MPL | 4352 | 0 | 0 | 11 | |
| GSE74703 | MPL | 4352 | 6 | 1 | 29 | |
| GSE74704 | MPL | 4352 | 2 | 0 | 18 | |
| TCGA | MPL | 4352 | 13 | 16 | 67 |
Total number of gains: 61; Total number of losses: 31; Total Number of normals: 396.
Somatic mutations of MPL:
Generating mutation plots.
Highly correlated genes for MPL:
Showing top 20/734 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPL | CTNNA2 | 0.749399 | 3 | 0 | 3 |
| MPL | HCN4 | 0.721988 | 3 | 0 | 3 |
| MPL | HOXD12 | 0.717865 | 4 | 0 | 4 |
| MPL | CSN2 | 0.715451 | 3 | 0 | 3 |
| MPL | ZG16 | 0.707362 | 4 | 0 | 4 |
| MPL | RPL34-AS1 | 0.705761 | 3 | 0 | 3 |
| MPL | HMHB1 | 0.704489 | 3 | 0 | 3 |
| MPL | INSL5 | 0.700584 | 3 | 0 | 3 |
| MPL | PYDC1 | 0.69378 | 4 | 0 | 3 |
| MPL | ZMAT4 | 0.686153 | 4 | 0 | 4 |
| MPL | ZNF853 | 0.683519 | 4 | 0 | 3 |
| MPL | EDDM3A | 0.681452 | 4 | 0 | 3 |
| MPL | GIPC3 | 0.67601 | 3 | 0 | 3 |
| MPL | CACNA1H | 0.672918 | 5 | 0 | 4 |
| MPL | ASB11 | 0.670927 | 3 | 0 | 3 |
| MPL | TMEM52 | 0.670054 | 3 | 0 | 3 |
| MPL | ATP6V1B1 | 0.669738 | 3 | 0 | 3 |
| MPL | ZNF517 | 0.669243 | 5 | 0 | 4 |
| MPL | TACR1 | 0.669234 | 5 | 0 | 5 |
| MPL | LIPE-AS1 | 0.668374 | 4 | 0 | 3 |
For details and further investigation, click here
