| Full name: LIM domain binding 3 | Alias Symbol: PDLIM6|KIAA0613|ZASP | ||
| Type: protein-coding gene | Cytoband: 10q23.2 | ||
| Entrez ID: 11155 | HGNC ID: HGNC:15710 | Ensembl Gene: ENSG00000122367 | OMIM ID: 605906 |
| Drug and gene relationship at DGIdb | |||
Expression of LDB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDB3 | 11155 | 213371_at | -2.9795 | 0.0694 | |
| GSE20347 | LDB3 | 11155 | 213717_at | -0.0372 | 0.6734 | |
| GSE23400 | LDB3 | 11155 | 213371_at | -1.2990 | 0.0000 | |
| GSE26886 | LDB3 | 11155 | 216888_at | -0.0477 | 0.8111 | |
| GSE29001 | LDB3 | 11155 | 213371_at | -1.3903 | 0.0252 | |
| GSE38129 | LDB3 | 11155 | 213717_at | -0.3043 | 0.0004 | |
| GSE45670 | LDB3 | 11155 | 213717_at | -0.1135 | 0.0986 | |
| GSE53622 | LDB3 | 11155 | 6451 | -3.1265 | 0.0000 | |
| GSE53624 | LDB3 | 11155 | 6451 | -3.2456 | 0.0000 | |
| GSE63941 | LDB3 | 11155 | 213717_at | 0.2051 | 0.1445 | |
| GSE77861 | LDB3 | 11155 | 213717_at | -0.1291 | 0.2415 | |
| GSE97050 | LDB3 | 11155 | A_32_P98227 | -2.1190 | 0.0782 | |
| SRP064894 | LDB3 | 11155 | RNAseq | -1.3538 | 0.0049 | |
| SRP133303 | LDB3 | 11155 | RNAseq | -1.6420 | 0.0359 | |
| SRP159526 | LDB3 | 11155 | RNAseq | -2.8860 | 0.0000 | |
| SRP193095 | LDB3 | 11155 | RNAseq | -0.0998 | 0.6349 | |
| SRP219564 | LDB3 | 11155 | RNAseq | -1.4122 | 0.1533 | |
| TCGA | LDB3 | 11155 | RNAseq | -1.4884 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by LDB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LDB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDB3 | 11155 | 1 | 7 | 22 | |
| GSE20123 | LDB3 | 11155 | 1 | 6 | 23 | |
| GSE43470 | LDB3 | 11155 | 1 | 6 | 36 | |
| GSE46452 | LDB3 | 11155 | 0 | 11 | 48 | |
| GSE47630 | LDB3 | 11155 | 2 | 14 | 24 | |
| GSE54993 | LDB3 | 11155 | 7 | 0 | 63 | |
| GSE54994 | LDB3 | 11155 | 1 | 11 | 41 | |
| GSE60625 | LDB3 | 11155 | 0 | 0 | 11 | |
| GSE74703 | LDB3 | 11155 | 1 | 4 | 31 | |
| GSE74704 | LDB3 | 11155 | 0 | 4 | 16 | |
| TCGA | LDB3 | 11155 | 7 | 27 | 62 |
Total number of gains: 21; Total number of losses: 90; Total Number of normals: 377.
Somatic mutations of LDB3:
Generating mutation plots.
Highly correlated genes for LDB3:
Showing top 20/1054 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDB3 | RBPMS2 | 0.895943 | 4 | 0 | 4 |
| LDB3 | XKR4 | 0.891908 | 4 | 0 | 4 |
| LDB3 | CLEC3B | 0.891693 | 3 | 0 | 3 |
| LDB3 | CYP21A2 | 0.860035 | 3 | 0 | 3 |
| LDB3 | LONRF2 | 0.837826 | 4 | 0 | 4 |
| LDB3 | EIF4E3 | 0.82317 | 5 | 0 | 5 |
| LDB3 | CASQ2 | 0.796893 | 8 | 0 | 8 |
| LDB3 | ZBTB10 | 0.79612 | 4 | 0 | 4 |
| LDB3 | LRFN5 | 0.794541 | 4 | 0 | 4 |
| LDB3 | GRHPR | 0.791558 | 3 | 0 | 3 |
| LDB3 | SNX1 | 0.790528 | 4 | 0 | 4 |
| LDB3 | C1QTNF7 | 0.788896 | 6 | 0 | 6 |
| LDB3 | PTCHD1 | 0.787112 | 4 | 0 | 4 |
| LDB3 | KCNT2 | 0.786259 | 4 | 0 | 4 |
| LDB3 | MBNL1-AS1 | 0.78486 | 3 | 0 | 3 |
| LDB3 | ADAMTS9-AS2 | 0.771712 | 4 | 0 | 4 |
| LDB3 | UBXN10 | 0.771125 | 4 | 0 | 3 |
| LDB3 | SORCS1 | 0.76955 | 5 | 0 | 4 |
| LDB3 | NFIA | 0.767363 | 5 | 0 | 4 |
| LDB3 | VMAC | 0.765695 | 3 | 0 | 3 |
For details and further investigation, click here
