| Full name: kelch like family member 2 | Alias Symbol: MAV | ||
| Type: protein-coding gene | Cytoband: 4q32.3 | ||
| Entrez ID: 11275 | HGNC ID: HGNC:6353 | Ensembl Gene: ENSG00000109466 | OMIM ID: 605774 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL2 | 11275 | 219157_at | -0.4788 | 0.1293 | |
| GSE20347 | KLHL2 | 11275 | 219157_at | -1.0551 | 0.0000 | |
| GSE23400 | KLHL2 | 11275 | 219157_at | -0.9888 | 0.0000 | |
| GSE26886 | KLHL2 | 11275 | 219157_at | -1.1098 | 0.0003 | |
| GSE29001 | KLHL2 | 11275 | 219157_at | -1.0058 | 0.0141 | |
| GSE38129 | KLHL2 | 11275 | 219157_at | -0.8053 | 0.0000 | |
| GSE45670 | KLHL2 | 11275 | 219157_at | -0.6896 | 0.0054 | |
| GSE53622 | KLHL2 | 11275 | 72496 | -1.1611 | 0.0000 | |
| GSE53624 | KLHL2 | 11275 | 72496 | -1.4098 | 0.0000 | |
| GSE63941 | KLHL2 | 11275 | 219157_at | -0.3843 | 0.4876 | |
| GSE77861 | KLHL2 | 11275 | 219157_at | -0.5565 | 0.0683 | |
| GSE97050 | KLHL2 | 11275 | A_23_P72503 | -0.5404 | 0.1888 | |
| SRP007169 | KLHL2 | 11275 | RNAseq | -1.9053 | 0.0002 | |
| SRP008496 | KLHL2 | 11275 | RNAseq | -1.8261 | 0.0000 | |
| SRP064894 | KLHL2 | 11275 | RNAseq | -1.5826 | 0.0000 | |
| SRP133303 | KLHL2 | 11275 | RNAseq | -0.4502 | 0.0102 | |
| SRP159526 | KLHL2 | 11275 | RNAseq | -1.4881 | 0.0000 | |
| SRP193095 | KLHL2 | 11275 | RNAseq | -1.0071 | 0.0000 | |
| SRP219564 | KLHL2 | 11275 | RNAseq | -1.4858 | 0.0012 | |
| TCGA | KLHL2 | 11275 | RNAseq | -0.1864 | 0.0015 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by KLHL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL2 | 11275 | 0 | 11 | 19 | |
| GSE20123 | KLHL2 | 11275 | 0 | 11 | 19 | |
| GSE43470 | KLHL2 | 11275 | 0 | 13 | 30 | |
| GSE46452 | KLHL2 | 11275 | 1 | 36 | 22 | |
| GSE47630 | KLHL2 | 11275 | 0 | 22 | 18 | |
| GSE54993 | KLHL2 | 11275 | 10 | 0 | 60 | |
| GSE54994 | KLHL2 | 11275 | 1 | 13 | 39 | |
| GSE60625 | KLHL2 | 11275 | 0 | 0 | 11 | |
| GSE74703 | KLHL2 | 11275 | 0 | 11 | 25 | |
| GSE74704 | KLHL2 | 11275 | 0 | 5 | 15 | |
| TCGA | KLHL2 | 11275 | 10 | 33 | 53 |
Total number of gains: 22; Total number of losses: 155; Total Number of normals: 311.
Somatic mutations of KLHL2:
Generating mutation plots.
Highly correlated genes for KLHL2:
Showing top 20/1618 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL2 | ACADM | 0.753571 | 11 | 0 | 11 |
| KLHL2 | CA13 | 0.753294 | 3 | 0 | 3 |
| KLHL2 | CPEB3 | 0.746342 | 10 | 0 | 10 |
| KLHL2 | STK39 | 0.740338 | 12 | 0 | 12 |
| KLHL2 | CNN3 | 0.736676 | 9 | 0 | 9 |
| KLHL2 | BLNK | 0.734198 | 11 | 0 | 11 |
| KLHL2 | FCHO2 | 0.732101 | 8 | 0 | 7 |
| KLHL2 | GOLPH3L | 0.728226 | 10 | 0 | 10 |
| KLHL2 | CDKN2AIP | 0.726684 | 11 | 0 | 10 |
| KLHL2 | KAT2B | 0.725669 | 12 | 0 | 11 |
| KLHL2 | CPPED1 | 0.725485 | 11 | 0 | 11 |
| KLHL2 | AK3 | 0.72304 | 7 | 0 | 7 |
| KLHL2 | ASAH1 | 0.721851 | 11 | 0 | 11 |
| KLHL2 | FLG-AS1 | 0.719959 | 6 | 0 | 6 |
| KLHL2 | SORT1 | 0.71976 | 11 | 0 | 10 |
| KLHL2 | HPGD | 0.719608 | 11 | 0 | 11 |
| KLHL2 | CAST | 0.718745 | 12 | 0 | 11 |
| KLHL2 | GPR108 | 0.718495 | 3 | 0 | 3 |
| KLHL2 | RSPH3 | 0.715833 | 4 | 0 | 4 |
| KLHL2 | RBM20 | 0.715671 | 5 | 0 | 5 |
For details and further investigation, click here
