| Full name: exocyst complex component 2 | Alias Symbol: FLJ11026|Sec5p | ||
| Type: protein-coding gene | Cytoband: 6p25.3 | ||
| Entrez ID: 55770 | HGNC ID: HGNC:24968 | Ensembl Gene: ENSG00000112685 | OMIM ID: 615329 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EXOC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of EXOC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC2 | 55770 | 226270_at | -0.1794 | 0.5509 | |
| GSE20347 | EXOC2 | 55770 | 219349_s_at | -0.1901 | 0.3020 | |
| GSE23400 | EXOC2 | 55770 | 219349_s_at | 0.0584 | 0.3360 | |
| GSE26886 | EXOC2 | 55770 | 226270_at | -0.8350 | 0.0000 | |
| GSE29001 | EXOC2 | 55770 | 219349_s_at | -0.0986 | 0.7034 | |
| GSE38129 | EXOC2 | 55770 | 219349_s_at | 0.0232 | 0.8917 | |
| GSE45670 | EXOC2 | 55770 | 226270_at | 0.0243 | 0.9025 | |
| GSE53622 | EXOC2 | 55770 | 58867 | -0.3870 | 0.0000 | |
| GSE53624 | EXOC2 | 55770 | 58867 | -0.3297 | 0.0005 | |
| GSE63941 | EXOC2 | 55770 | 226270_at | -0.6068 | 0.0683 | |
| GSE77861 | EXOC2 | 55770 | 219349_s_at | -0.1082 | 0.5981 | |
| GSE97050 | EXOC2 | 55770 | A_23_P214354 | -0.0558 | 0.8657 | |
| SRP007169 | EXOC2 | 55770 | RNAseq | 0.0467 | 0.9052 | |
| SRP008496 | EXOC2 | 55770 | RNAseq | 0.1588 | 0.5262 | |
| SRP064894 | EXOC2 | 55770 | RNAseq | 0.0093 | 0.9705 | |
| SRP133303 | EXOC2 | 55770 | RNAseq | -0.1087 | 0.4431 | |
| SRP159526 | EXOC2 | 55770 | RNAseq | -0.0644 | 0.7249 | |
| SRP193095 | EXOC2 | 55770 | RNAseq | -0.1791 | 0.0613 | |
| SRP219564 | EXOC2 | 55770 | RNAseq | 0.1183 | 0.7319 | |
| TCGA | EXOC2 | 55770 | RNAseq | -0.0201 | 0.6966 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EXOC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC2 | 55770 | 3 | 5 | 22 | |
| GSE20123 | EXOC2 | 55770 | 3 | 5 | 22 | |
| GSE43470 | EXOC2 | 55770 | 9 | 2 | 32 | |
| GSE46452 | EXOC2 | 55770 | 1 | 10 | 48 | |
| GSE47630 | EXOC2 | 55770 | 7 | 8 | 25 | |
| GSE54993 | EXOC2 | 55770 | 1 | 3 | 66 | |
| GSE54994 | EXOC2 | 55770 | 9 | 2 | 42 | |
| GSE60625 | EXOC2 | 55770 | 0 | 1 | 10 | |
| GSE74703 | EXOC2 | 55770 | 8 | 2 | 26 | |
| GSE74704 | EXOC2 | 55770 | 2 | 2 | 16 | |
| TCGA | EXOC2 | 55770 | 16 | 29 | 51 |
Total number of gains: 59; Total number of losses: 69; Total Number of normals: 360.
Somatic mutations of EXOC2:
Generating mutation plots.
Highly correlated genes for EXOC2:
Showing top 20/603 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC2 | PPM1B | 0.808701 | 3 | 0 | 3 |
| EXOC2 | SAMD8 | 0.786609 | 3 | 0 | 3 |
| EXOC2 | PLEKHF2 | 0.782514 | 3 | 0 | 3 |
| EXOC2 | DNAJB6 | 0.770998 | 3 | 0 | 3 |
| EXOC2 | MRPL46 | 0.759929 | 3 | 0 | 3 |
| EXOC2 | NCOA2 | 0.752812 | 3 | 0 | 3 |
| EXOC2 | ZNF543 | 0.733636 | 3 | 0 | 3 |
| EXOC2 | CD59 | 0.732786 | 3 | 0 | 3 |
| EXOC2 | NBPF1 | 0.722962 | 3 | 0 | 3 |
| EXOC2 | TAB3 | 0.721683 | 3 | 0 | 3 |
| EXOC2 | ZNF441 | 0.715354 | 3 | 0 | 3 |
| EXOC2 | DRAM2 | 0.71001 | 3 | 0 | 3 |
| EXOC2 | TRAF6 | 0.709188 | 4 | 0 | 4 |
| EXOC2 | RNF10 | 0.709144 | 4 | 0 | 3 |
| EXOC2 | THAP1 | 0.709084 | 3 | 0 | 3 |
| EXOC2 | ZDHHC21 | 0.708198 | 3 | 0 | 3 |
| EXOC2 | LRRC28 | 0.707371 | 3 | 0 | 3 |
| EXOC2 | ACAA1 | 0.707262 | 4 | 0 | 3 |
| EXOC2 | MBD1 | 0.706158 | 3 | 0 | 3 |
| EXOC2 | ZNF564 | 0.70593 | 3 | 0 | 3 |
For details and further investigation, click here
