| Full name: cytoplasmic polyadenylation element binding protein 4 | Alias Symbol: KIAA1673 | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 80315 | HGNC ID: HGNC:21747 | Ensembl Gene: ENSG00000113742 | OMIM ID: 610607 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CPEB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis |
Expression of CPEB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPEB4 | 80315 | 224829_at | -0.7336 | 0.1026 | |
| GSE26886 | CPEB4 | 80315 | 224831_at | -1.8117 | 0.0000 | |
| GSE45670 | CPEB4 | 80315 | 224831_at | -0.4739 | 0.0291 | |
| GSE53622 | CPEB4 | 80315 | 10858 | -1.4381 | 0.0000 | |
| GSE53624 | CPEB4 | 80315 | 148331 | -1.4707 | 0.0000 | |
| GSE63941 | CPEB4 | 80315 | 224831_at | -2.0146 | 0.0045 | |
| GSE77861 | CPEB4 | 80315 | 224831_at | -1.4335 | 0.0479 | |
| GSE97050 | CPEB4 | 80315 | A_23_P251937 | -0.4414 | 0.1235 | |
| SRP007169 | CPEB4 | 80315 | RNAseq | -3.2036 | 0.0000 | |
| SRP008496 | CPEB4 | 80315 | RNAseq | -2.9753 | 0.0000 | |
| SRP064894 | CPEB4 | 80315 | RNAseq | -1.6774 | 0.0000 | |
| SRP133303 | CPEB4 | 80315 | RNAseq | -0.6825 | 0.0000 | |
| SRP159526 | CPEB4 | 80315 | RNAseq | -1.5907 | 0.0016 | |
| SRP193095 | CPEB4 | 80315 | RNAseq | -1.3996 | 0.0000 | |
| SRP219564 | CPEB4 | 80315 | RNAseq | -1.4042 | 0.0002 | |
| TCGA | CPEB4 | 80315 | RNAseq | -0.3653 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by CPEB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPEB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPEB4 | 80315 | 2 | 13 | 15 | |
| GSE20123 | CPEB4 | 80315 | 2 | 13 | 15 | |
| GSE43470 | CPEB4 | 80315 | 1 | 10 | 32 | |
| GSE46452 | CPEB4 | 80315 | 0 | 27 | 32 | |
| GSE47630 | CPEB4 | 80315 | 0 | 20 | 20 | |
| GSE54993 | CPEB4 | 80315 | 9 | 2 | 59 | |
| GSE54994 | CPEB4 | 80315 | 2 | 17 | 34 | |
| GSE60625 | CPEB4 | 80315 | 1 | 0 | 10 | |
| GSE74703 | CPEB4 | 80315 | 1 | 7 | 28 | |
| GSE74704 | CPEB4 | 80315 | 1 | 6 | 13 | |
| TCGA | CPEB4 | 80315 | 8 | 34 | 54 |
Total number of gains: 27; Total number of losses: 149; Total Number of normals: 312.
Somatic mutations of CPEB4:
Generating mutation plots.
Highly correlated genes for CPEB4:
Showing top 20/1526 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPEB4 | GGA3 | 0.860654 | 3 | 0 | 3 |
| CPEB4 | CAST | 0.804012 | 7 | 0 | 7 |
| CPEB4 | ITPKC | 0.790192 | 7 | 0 | 7 |
| CPEB4 | PCGF3 | 0.786997 | 3 | 0 | 3 |
| CPEB4 | CLIP1 | 0.784482 | 8 | 0 | 8 |
| CPEB4 | OR7A10 | 0.78345 | 3 | 0 | 3 |
| CPEB4 | ZNF175 | 0.77965 | 3 | 0 | 3 |
| CPEB4 | FPGT | 0.77863 | 3 | 0 | 3 |
| CPEB4 | C18orf25 | 0.778406 | 7 | 0 | 7 |
| CPEB4 | CA13 | 0.777141 | 3 | 0 | 3 |
| CPEB4 | VSIG10L | 0.775544 | 6 | 0 | 6 |
| CPEB4 | ACADVL | 0.77104 | 6 | 0 | 6 |
| CPEB4 | GDPD3 | 0.770869 | 6 | 0 | 6 |
| CPEB4 | RXRA | 0.770678 | 3 | 0 | 3 |
| CPEB4 | KRT78 | 0.769026 | 6 | 0 | 6 |
| CPEB4 | SCNN1B | 0.76846 | 6 | 0 | 6 |
| CPEB4 | IK | 0.768074 | 6 | 0 | 6 |
| CPEB4 | RAB5B | 0.766246 | 7 | 0 | 7 |
| CPEB4 | RAB11A | 0.766152 | 7 | 0 | 7 |
| CPEB4 | PDE7B | 0.765084 | 3 | 0 | 3 |
For details and further investigation, click here
