| Full name: alkB homolog 3, alpha-ketoglutaratedependent dioxygenase | Alias Symbol: DEPC-1 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 221120 | HGNC ID: HGNC:30141 | Ensembl Gene: ENSG00000166199 | OMIM ID: 610603 |
| Drug and gene relationship at DGIdb | |||
Expression of ALKBH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALKBH3 | 221120 | 226127_at | -0.0159 | 0.9737 | |
| GSE26886 | ALKBH3 | 221120 | 226127_at | 0.1065 | 0.7475 | |
| GSE45670 | ALKBH3 | 221120 | 226127_at | 0.0202 | 0.9128 | |
| GSE53622 | ALKBH3 | 221120 | 139696 | 0.0706 | 0.5644 | |
| GSE53624 | ALKBH3 | 221120 | 139696 | -0.2277 | 0.0551 | |
| GSE63941 | ALKBH3 | 221120 | 226127_at | 0.1101 | 0.8755 | |
| GSE77861 | ALKBH3 | 221120 | 226127_at | -0.1974 | 0.4144 | |
| GSE97050 | ALKBH3 | 221120 | A_33_P3225250 | 0.0473 | 0.8541 | |
| SRP007169 | ALKBH3 | 221120 | RNAseq | -0.3472 | 0.4350 | |
| SRP008496 | ALKBH3 | 221120 | RNAseq | 0.2013 | 0.5616 | |
| SRP064894 | ALKBH3 | 221120 | RNAseq | 0.3439 | 0.1154 | |
| SRP133303 | ALKBH3 | 221120 | RNAseq | 0.3877 | 0.1911 | |
| SRP159526 | ALKBH3 | 221120 | RNAseq | -0.4560 | 0.0143 | |
| SRP193095 | ALKBH3 | 221120 | RNAseq | -0.3273 | 0.0011 | |
| SRP219564 | ALKBH3 | 221120 | RNAseq | -0.0455 | 0.8949 | |
| TCGA | ALKBH3 | 221120 | RNAseq | 0.0485 | 0.4546 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALKBH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALKBH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALKBH3 | 221120 | 2 | 7 | 21 | |
| GSE20123 | ALKBH3 | 221120 | 2 | 6 | 22 | |
| GSE43470 | ALKBH3 | 221120 | 3 | 4 | 36 | |
| GSE46452 | ALKBH3 | 221120 | 8 | 5 | 46 | |
| GSE47630 | ALKBH3 | 221120 | 3 | 9 | 28 | |
| GSE54993 | ALKBH3 | 221120 | 3 | 0 | 67 | |
| GSE54994 | ALKBH3 | 221120 | 3 | 9 | 41 | |
| GSE60625 | ALKBH3 | 221120 | 0 | 0 | 11 | |
| GSE74703 | ALKBH3 | 221120 | 2 | 2 | 32 | |
| GSE74704 | ALKBH3 | 221120 | 2 | 5 | 13 | |
| TCGA | ALKBH3 | 221120 | 13 | 21 | 62 |
Total number of gains: 41; Total number of losses: 68; Total Number of normals: 379.
Somatic mutations of ALKBH3:
Generating mutation plots.
Highly correlated genes for ALKBH3:
Showing top 20/118 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALKBH3 | SMN2 | 0.879065 | 3 | 0 | 3 |
| ALKBH3 | OSBPL2 | 0.791784 | 3 | 0 | 3 |
| ALKBH3 | TRIP4 | 0.739164 | 3 | 0 | 3 |
| ALKBH3 | UBE2E2 | 0.733517 | 3 | 0 | 3 |
| ALKBH3 | PPP4R2 | 0.733043 | 3 | 0 | 3 |
| ALKBH3 | B4GALT5 | 0.730735 | 3 | 0 | 3 |
| ALKBH3 | CAPRIN1 | 0.730018 | 3 | 0 | 3 |
| ALKBH3 | STYX | 0.721455 | 3 | 0 | 3 |
| ALKBH3 | PSMB1 | 0.717987 | 3 | 0 | 3 |
| ALKBH3 | COPS5 | 0.716999 | 3 | 0 | 3 |
| ALKBH3 | EPB41L5 | 0.711455 | 4 | 0 | 3 |
| ALKBH3 | C6orf120 | 0.711231 | 3 | 0 | 3 |
| ALKBH3 | EPRS | 0.707858 | 4 | 0 | 3 |
| ALKBH3 | TBC1D23 | 0.707449 | 3 | 0 | 3 |
| ALKBH3 | RABIF | 0.706656 | 3 | 0 | 3 |
| ALKBH3 | BNIP2 | 0.703616 | 3 | 0 | 3 |
| ALKBH3 | TRAF6 | 0.703041 | 3 | 0 | 3 |
| ALKBH3 | VPS53 | 0.698343 | 3 | 0 | 3 |
| ALKBH3 | MINK1 | 0.690131 | 4 | 0 | 4 |
| ALKBH3 | TAOK3 | 0.68993 | 3 | 0 | 3 |
For details and further investigation, click here
