| Full name: transient receptor potential cation channel subfamily V member 3 | Alias Symbol: VRL3 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 162514 | HGNC ID: HGNC:18084 | Ensembl Gene: ENSG00000167723 | OMIM ID: 607066 |
| Drug and gene relationship at DGIdb | |||
TRPV3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of TRPV3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPV3 | 162514 | 1552586_at | -0.0231 | 0.9613 | |
| GSE26886 | TRPV3 | 162514 | 1552586_at | 0.0407 | 0.7414 | |
| GSE45670 | TRPV3 | 162514 | 1552586_at | -0.0157 | 0.9073 | |
| GSE53622 | TRPV3 | 162514 | 98474 | 0.9947 | 0.0000 | |
| GSE53624 | TRPV3 | 162514 | 98474 | 0.1662 | 0.1339 | |
| GSE63941 | TRPV3 | 162514 | 1552586_at | 0.1320 | 0.3014 | |
| GSE77861 | TRPV3 | 162514 | 1552586_at | -0.1199 | 0.1356 | |
| GSE97050 | TRPV3 | 162514 | A_23_P49862 | 0.2012 | 0.3727 | |
| SRP007169 | TRPV3 | 162514 | RNAseq | 2.5032 | 0.0003 | |
| SRP064894 | TRPV3 | 162514 | RNAseq | 1.7829 | 0.0012 | |
| SRP133303 | TRPV3 | 162514 | RNAseq | 1.5709 | 0.0043 | |
| SRP159526 | TRPV3 | 162514 | RNAseq | 2.0273 | 0.0001 | |
| SRP193095 | TRPV3 | 162514 | RNAseq | 1.4832 | 0.0000 | |
| SRP219564 | TRPV3 | 162514 | RNAseq | 1.4253 | 0.1035 | |
| TCGA | TRPV3 | 162514 | RNAseq | 1.0200 | 0.0003 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by TRPV3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPV3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPV3 | 162514 | 5 | 3 | 22 | |
| GSE20123 | TRPV3 | 162514 | 5 | 4 | 21 | |
| GSE43470 | TRPV3 | 162514 | 1 | 6 | 36 | |
| GSE46452 | TRPV3 | 162514 | 34 | 1 | 24 | |
| GSE47630 | TRPV3 | 162514 | 7 | 1 | 32 | |
| GSE54993 | TRPV3 | 162514 | 4 | 3 | 63 | |
| GSE54994 | TRPV3 | 162514 | 5 | 9 | 39 | |
| GSE60625 | TRPV3 | 162514 | 4 | 0 | 7 | |
| GSE74703 | TRPV3 | 162514 | 1 | 3 | 32 | |
| GSE74704 | TRPV3 | 162514 | 3 | 2 | 15 | |
| TCGA | TRPV3 | 162514 | 17 | 21 | 58 |
Total number of gains: 86; Total number of losses: 53; Total Number of normals: 349.
Somatic mutations of TRPV3:
Generating mutation plots.
Highly correlated genes for TRPV3:
Showing top 20/145 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPV3 | P2RY4 | 0.718662 | 3 | 0 | 3 |
| TRPV3 | NRG3 | 0.709063 | 4 | 0 | 4 |
| TRPV3 | LCT | 0.705238 | 3 | 0 | 3 |
| TRPV3 | NXF3 | 0.699822 | 4 | 0 | 3 |
| TRPV3 | NKX2-8 | 0.699109 | 3 | 0 | 3 |
| TRPV3 | C14orf180 | 0.697422 | 3 | 0 | 3 |
| TRPV3 | CTSE | 0.6843 | 3 | 0 | 3 |
| TRPV3 | SLC5A4 | 0.676623 | 3 | 0 | 3 |
| TRPV3 | NLRP6 | 0.676304 | 3 | 0 | 3 |
| TRPV3 | NCAN | 0.670406 | 3 | 0 | 3 |
| TRPV3 | RASAL1 | 0.667018 | 3 | 0 | 3 |
| TRPV3 | FGG | 0.66642 | 3 | 0 | 3 |
| TRPV3 | TULP1 | 0.664237 | 4 | 0 | 3 |
| TRPV3 | C11orf86 | 0.658215 | 3 | 0 | 3 |
| TRPV3 | C3orf22 | 0.655378 | 3 | 0 | 3 |
| TRPV3 | C9orf131 | 0.654259 | 5 | 0 | 4 |
| TRPV3 | MYH13 | 0.652699 | 3 | 0 | 3 |
| TRPV3 | EPS8L2 | 0.652533 | 3 | 0 | 3 |
| TRPV3 | RGL4 | 0.649939 | 4 | 0 | 3 |
| TRPV3 | OR1F1 | 0.649367 | 4 | 0 | 3 |
For details and further investigation, click here
