RASAL1

 

Full name: RAS protein activator like 1 Alias Symbol: RASAL
Type: protein-coding gene Cytoband: 12q24.13
Entrez ID: 8437 HGNC ID: HGNC:9873 Ensembl Gene: ENSG00000111344 OMIM ID: 604118
Drug and gene relationship at DGIdb

 

RASAL1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway

 

Expression of RASAL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RASAL1 8437 219752_at -0.9348 0.1976
GSE20347 RASAL1 8437 219752_at -1.4470 0.0000
GSE23400 RASAL1 8437 219752_at -1.1213 0.0000
GSE26886 RASAL1 8437 219752_at -1.6808 0.0000
GSE29001 RASAL1 8437 219752_at -1.3893 0.0000
GSE38129 RASAL1 8437 219752_at -1.0543 0.0000
GSE45670 RASAL1 8437 219752_at -0.0333 0.9489
GSE53622 RASAL1 8437 97104 -1.5375 0.0000
GSE53624 RASAL1 8437 97104 -2.0427 0.0000
GSE63941 RASAL1 8437 219752_at 0.3275 0.2769
GSE77861 RASAL1 8437 219752_at -1.0507 0.0070
GSE97050 RASAL1 8437 A_23_P139600 0.0510 0.8658
SRP007169 RASAL1 8437 RNAseq -3.3519 0.0000
SRP008496 RASAL1 8437 RNAseq -3.6776 0.0000
SRP064894 RASAL1 8437 RNAseq -2.5839 0.0000
SRP133303 RASAL1 8437 RNAseq -2.2463 0.0000
SRP159526 RASAL1 8437 RNAseq -2.4120 0.0000
SRP193095 RASAL1 8437 RNAseq -1.6527 0.0000
SRP219564 RASAL1 8437 RNAseq -2.1591 0.0464
TCGA RASAL1 8437 RNAseq -0.1649 0.5175

Upregulated datasets: 0; Downregulated datasets: 15.  

 

Survival by RASAL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RASAL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RASAL1 8437 4 3 23
GSE20123 RASAL1 8437 4 3 23
GSE43470 RASAL1 8437 2 0 41
GSE46452 RASAL1 8437 9 1 49
GSE47630 RASAL1 8437 9 3 28
GSE54993 RASAL1 8437 0 5 65
GSE54994 RASAL1 8437 4 2 47
GSE60625 RASAL1 8437 0 0 11
GSE74703 RASAL1 8437 2 0 34
GSE74704 RASAL1 8437 2 2 16
TCGA RASAL1 8437 22 11 63

Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.  

 

Somatic mutations of RASAL1:

 

Generating mutation plots.

 

Highly correlated genes for RASAL1:

 

Showing top 20/1556 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RASAL1EPS8L20.83464911011
RASAL1KLK130.81595312012
RASAL1SCNN1B0.81591412011
RASAL1PRSS270.811521808
RASAL1CXCR20.80985610010
RASAL1NCCRP10.807903404
RASAL1CLIC30.8049210010
RASAL1TGM10.80426412012
RASAL1CLCA40.80081912012
RASAL1EVPL0.79915712012
RASAL1SPINK50.7989112012
RASAL1TRIP100.79764210010
RASAL1GDPD30.79723612012
RASAL1BLNK0.79714111010
RASAL1CWH430.79404410010
RASAL1CEACAM70.79034212011
RASAL1VPS4B0.7891910010
RASAL1ACAA10.788687808
RASAL1TTC39A0.78778410010
RASAL1TMPRSS11E0.78474111011

For details and further investigation, click here