| Full name: tetratricopeptide repeat domain 22 | Alias Symbol: FLJ20619 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 55001 | HGNC ID: HGNC:26067 | Ensembl Gene: ENSG00000006555 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TTC22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC22 | 55001 | 235651_at | -1.3631 | 0.2111 | |
| GSE20347 | TTC22 | 55001 | 220309_at | -0.6872 | 0.0000 | |
| GSE23400 | TTC22 | 55001 | 220309_at | -0.4564 | 0.0000 | |
| GSE26886 | TTC22 | 55001 | 235651_at | -2.5748 | 0.0000 | |
| GSE29001 | TTC22 | 55001 | 220309_at | -1.0008 | 0.0005 | |
| GSE38129 | TTC22 | 55001 | 220309_at | -0.6758 | 0.0019 | |
| GSE45670 | TTC22 | 55001 | 235651_at | -0.5166 | 0.1896 | |
| GSE53622 | TTC22 | 55001 | 33962 | -1.5438 | 0.0000 | |
| GSE53624 | TTC22 | 55001 | 33962 | -1.7180 | 0.0000 | |
| GSE63941 | TTC22 | 55001 | 235651_at | 3.1632 | 0.0371 | |
| GSE77861 | TTC22 | 55001 | 235651_at | -2.0129 | 0.0042 | |
| GSE97050 | TTC22 | 55001 | A_24_P11436 | -0.0447 | 0.9567 | |
| SRP007169 | TTC22 | 55001 | RNAseq | -3.4250 | 0.0000 | |
| SRP008496 | TTC22 | 55001 | RNAseq | -3.5406 | 0.0000 | |
| SRP064894 | TTC22 | 55001 | RNAseq | -2.8331 | 0.0000 | |
| SRP133303 | TTC22 | 55001 | RNAseq | -2.3947 | 0.0000 | |
| SRP159526 | TTC22 | 55001 | RNAseq | -2.2415 | 0.0000 | |
| SRP193095 | TTC22 | 55001 | RNAseq | -1.9309 | 0.0000 | |
| SRP219564 | TTC22 | 55001 | RNAseq | -2.5311 | 0.0199 | |
| TCGA | TTC22 | 55001 | RNAseq | 0.2046 | 0.2284 |
Upregulated datasets: 1; Downregulated datasets: 12.
Survival by TTC22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC22 | 55001 | 3 | 3 | 24 | |
| GSE20123 | TTC22 | 55001 | 3 | 2 | 25 | |
| GSE43470 | TTC22 | 55001 | 7 | 2 | 34 | |
| GSE46452 | TTC22 | 55001 | 2 | 1 | 56 | |
| GSE47630 | TTC22 | 55001 | 8 | 4 | 28 | |
| GSE54993 | TTC22 | 55001 | 0 | 0 | 70 | |
| GSE54994 | TTC22 | 55001 | 10 | 3 | 40 | |
| GSE60625 | TTC22 | 55001 | 0 | 0 | 11 | |
| GSE74703 | TTC22 | 55001 | 5 | 1 | 30 | |
| GSE74704 | TTC22 | 55001 | 2 | 0 | 18 | |
| TCGA | TTC22 | 55001 | 10 | 18 | 68 |
Total number of gains: 50; Total number of losses: 34; Total Number of normals: 404.
Somatic mutations of TTC22:
Generating mutation plots.
Highly correlated genes for TTC22:
Showing top 20/1447 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC22 | GBP6 | 0.906174 | 4 | 0 | 4 |
| TTC22 | PRSS27 | 0.863298 | 7 | 0 | 7 |
| TTC22 | CYSRT1 | 0.862048 | 6 | 0 | 6 |
| TTC22 | TMEM154 | 0.857461 | 7 | 0 | 7 |
| TTC22 | VSIG10L | 0.849705 | 7 | 0 | 7 |
| TTC22 | CAPN14 | 0.848249 | 6 | 0 | 6 |
| TTC22 | CCNYL1 | 0.84103 | 4 | 0 | 4 |
| TTC22 | FAM3D | 0.839749 | 7 | 0 | 7 |
| TTC22 | C6orf132 | 0.828073 | 8 | 0 | 8 |
| TTC22 | ULK3 | 0.827919 | 6 | 0 | 6 |
| TTC22 | FUT3 | 0.825279 | 11 | 0 | 11 |
| TTC22 | CNFN | 0.824925 | 7 | 0 | 7 |
| TTC22 | SCNN1B | 0.824743 | 11 | 0 | 11 |
| TTC22 | EPS8L2 | 0.824664 | 11 | 0 | 11 |
| TTC22 | UPK3B | 0.824316 | 3 | 0 | 3 |
| TTC22 | ATP13A4 | 0.81815 | 7 | 0 | 7 |
| TTC22 | SFTA2 | 0.817904 | 4 | 0 | 4 |
| TTC22 | PRSS2 | 0.817682 | 9 | 0 | 9 |
| TTC22 | BTBD11 | 0.816304 | 7 | 0 | 7 |
| TTC22 | SLC13A4 | 0.816156 | 11 | 0 | 11 |
For details and further investigation, click here
