| Full name: serine protease 2 | Alias Symbol: TRY2 | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 5645 | HGNC ID: HGNC:9483 | Ensembl Gene: ENSG00000275896 | OMIM ID: 601564 |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS2 | 5645 | 205402_x_at | -1.4054 | 0.1511 | |
| GSE20347 | PRSS2 | 5645 | 205402_x_at | -1.5507 | 0.0000 | |
| GSE23400 | PRSS2 | 5645 | 205402_x_at | -0.8216 | 0.0000 | |
| GSE26886 | PRSS2 | 5645 | 205402_x_at | -2.1513 | 0.0000 | |
| GSE29001 | PRSS2 | 5645 | 205402_x_at | -1.7386 | 0.0000 | |
| GSE38129 | PRSS2 | 5645 | 205402_x_at | -1.2994 | 0.0000 | |
| GSE45670 | PRSS2 | 5645 | 205402_x_at | -0.5068 | 0.2006 | |
| GSE63941 | PRSS2 | 5645 | 205402_x_at | 0.0547 | 0.9435 | |
| GSE77861 | PRSS2 | 5645 | 205402_x_at | -1.0181 | 0.0011 | |
| GSE97050 | PRSS2 | 5645 | A_23_P310274 | 0.1503 | 0.7006 |
Upregulated datasets: 0; Downregulated datasets: 5.
Copy number change of PRSS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS2 | 5645 | 3 | 2 | 25 | |
| GSE20123 | PRSS2 | 5645 | 3 | 2 | 25 | |
| GSE43470 | PRSS2 | 5645 | 2 | 4 | 37 | |
| GSE46452 | PRSS2 | 5645 | 7 | 2 | 50 | |
| GSE47630 | PRSS2 | 5645 | 6 | 7 | 27 | |
| GSE54993 | PRSS2 | 5645 | 3 | 4 | 63 | |
| GSE54994 | PRSS2 | 5645 | 5 | 8 | 40 | |
| GSE60625 | PRSS2 | 5645 | 0 | 0 | 11 | |
| GSE74703 | PRSS2 | 5645 | 2 | 4 | 30 | |
| GSE74704 | PRSS2 | 5645 | 1 | 2 | 17 |
Total number of gains: 32; Total number of losses: 35; Total Number of normals: 325.
Somatic mutations of PRSS2:
Generating mutation plots.
Highly correlated genes for PRSS2:
Showing top 20/1156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS2 | CYSRT1 | 0.912445 | 4 | 0 | 4 |
| PRSS2 | PRSS3 | 0.901122 | 11 | 0 | 11 |
| PRSS2 | RAET1E | 0.869398 | 5 | 0 | 5 |
| PRSS2 | VSIG10L | 0.867548 | 5 | 0 | 5 |
| PRSS2 | FUT6 | 0.861599 | 8 | 0 | 8 |
| PRSS2 | MPZL3 | 0.859895 | 4 | 0 | 4 |
| PRSS2 | IL36A | 0.85795 | 9 | 0 | 9 |
| PRSS2 | RANBP9 | 0.85712 | 8 | 0 | 8 |
| PRSS2 | TMPRSS11E | 0.856566 | 9 | 0 | 9 |
| PRSS2 | FCHO2 | 0.85455 | 4 | 0 | 4 |
| PRSS2 | TP53INP2 | 0.853674 | 3 | 0 | 3 |
| PRSS2 | USP6NL | 0.851638 | 8 | 0 | 8 |
| PRSS2 | TRIP10 | 0.849889 | 8 | 0 | 8 |
| PRSS2 | GDPD3 | 0.848707 | 10 | 0 | 10 |
| PRSS2 | KLB | 0.841961 | 4 | 0 | 4 |
| PRSS2 | PADI1 | 0.84127 | 8 | 0 | 8 |
| PRSS2 | C18orf25 | 0.839628 | 8 | 0 | 8 |
| PRSS2 | MYO5B | 0.830078 | 5 | 0 | 5 |
| PRSS2 | PRSS27 | 0.828992 | 6 | 0 | 5 |
| PRSS2 | GBP6 | 0.825231 | 4 | 0 | 4 |
For details and further investigation, click here
