| Full name: unc-5 netrin receptor A | Alias Symbol: KIAA1976|UNC5H1 | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 90249 | HGNC ID: HGNC:12567 | Ensembl Gene: ENSG00000113763 | OMIM ID: 607869 |
| Drug and gene relationship at DGIdb | |||
UNC5A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of UNC5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNC5A | 90249 | 243833_at | -0.0653 | 0.8492 | |
| GSE26886 | UNC5A | 90249 | 243833_at | 0.1581 | 0.1896 | |
| GSE45670 | UNC5A | 90249 | 243833_at | -0.0029 | 0.9760 | |
| GSE53622 | UNC5A | 90249 | 86008 | 0.1975 | 0.0867 | |
| GSE53624 | UNC5A | 90249 | 86008 | -0.1265 | 0.2650 | |
| GSE63941 | UNC5A | 90249 | 243833_at | 0.0561 | 0.7573 | |
| GSE77861 | UNC5A | 90249 | 243833_at | 0.0290 | 0.8646 | |
| GSE97050 | UNC5A | 90249 | A_33_P3379001 | 0.0561 | 0.7919 | |
| TCGA | UNC5A | 90249 | RNAseq | -1.8421 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by UNC5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNC5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNC5A | 90249 | 2 | 13 | 15 | |
| GSE20123 | UNC5A | 90249 | 2 | 13 | 15 | |
| GSE43470 | UNC5A | 90249 | 1 | 11 | 31 | |
| GSE46452 | UNC5A | 90249 | 0 | 27 | 32 | |
| GSE47630 | UNC5A | 90249 | 0 | 20 | 20 | |
| GSE54993 | UNC5A | 90249 | 10 | 2 | 58 | |
| GSE54994 | UNC5A | 90249 | 2 | 17 | 34 | |
| GSE60625 | UNC5A | 90249 | 1 | 0 | 10 | |
| GSE74703 | UNC5A | 90249 | 1 | 7 | 28 | |
| GSE74704 | UNC5A | 90249 | 1 | 6 | 13 | |
| TCGA | UNC5A | 90249 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of UNC5A:
Generating mutation plots.
Highly correlated genes for UNC5A:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNC5A | NMRK2 | 0.780299 | 3 | 0 | 3 |
| UNC5A | DSCR10 | 0.743263 | 3 | 0 | 3 |
| UNC5A | NKX2-5 | 0.72945 | 3 | 0 | 3 |
| UNC5A | OAZ2 | 0.721235 | 3 | 0 | 3 |
| UNC5A | KRTAP12-2 | 0.719117 | 3 | 0 | 3 |
| UNC5A | BET1L | 0.705857 | 3 | 0 | 3 |
| UNC5A | SLC26A5 | 0.705173 | 3 | 0 | 3 |
| UNC5A | TCF23 | 0.701848 | 3 | 0 | 3 |
| UNC5A | ZC3H18 | 0.699311 | 3 | 0 | 3 |
| UNC5A | SPEG | 0.686663 | 3 | 0 | 3 |
| UNC5A | DEFB132 | 0.685275 | 3 | 0 | 3 |
| UNC5A | ZNF676 | 0.684513 | 3 | 0 | 3 |
| UNC5A | KLHL31 | 0.684321 | 3 | 0 | 3 |
| UNC5A | OR2T12 | 0.684212 | 3 | 0 | 3 |
| UNC5A | MATN4 | 0.682813 | 4 | 0 | 4 |
| UNC5A | KRTAP10-9 | 0.682702 | 3 | 0 | 3 |
| UNC5A | SLC13A2 | 0.681474 | 5 | 0 | 4 |
| UNC5A | ETV2 | 0.67907 | 3 | 0 | 3 |
| UNC5A | KIR3DL2 | 0.678458 | 3 | 0 | 3 |
| UNC5A | CCDC154 | 0.673867 | 5 | 0 | 4 |
For details and further investigation, click here
