USP1

 

Full name: ubiquitin specific peptidase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p31.3
Entrez ID: 7398 HGNC ID: HGNC:12607 Ensembl Gene: ENSG00000162607 OMIM ID: 603478
Drug and gene relationship at DGIdb
Screen Evidence:

 

USP1 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of USP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 USP1 7398 202413_s_at 0.3225 0.5572
GSE20347 USP1 7398 202413_s_at 0.5513 0.0118
GSE23400 USP1 7398 202413_s_at 0.7202 0.0000
GSE26886 USP1 7398 202413_s_at 0.2236 0.3383
GSE29001 USP1 7398 202413_s_at 0.7494 0.0160
GSE38129 USP1 7398 202413_s_at 0.5436 0.0003
GSE45670 USP1 7398 202413_s_at 0.0183 0.9301
GSE53622 USP1 7398 75699 0.4683 0.0000
GSE53624 USP1 7398 75699 0.6364 0.0000
GSE63941 USP1 7398 202413_s_at 1.3163 0.0025
GSE77861 USP1 7398 202413_s_at 0.2780 0.4450
GSE97050 USP1 7398 A_23_P11652 0.2459 0.4051
SRP007169 USP1 7398 RNAseq 0.3391 0.3997
SRP008496 USP1 7398 RNAseq 0.2966 0.1200
SRP064894 USP1 7398 RNAseq 0.3447 0.1034
SRP133303 USP1 7398 RNAseq 0.7275 0.0010
SRP159526 USP1 7398 RNAseq 0.0134 0.9669
SRP193095 USP1 7398 RNAseq 0.1131 0.3210
SRP219564 USP1 7398 RNAseq 0.4084 0.3028
TCGA USP1 7398 RNAseq 0.1602 0.0044

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by USP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of USP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 USP1 7398 3 6 21
GSE20123 USP1 7398 3 5 22
GSE43470 USP1 7398 5 2 36
GSE46452 USP1 7398 1 1 57
GSE47630 USP1 7398 8 5 27
GSE54993 USP1 7398 0 0 70
GSE54994 USP1 7398 6 4 43
GSE60625 USP1 7398 0 0 11
GSE74703 USP1 7398 4 2 30
GSE74704 USP1 7398 2 2 16
TCGA USP1 7398 10 20 66

Total number of gains: 42; Total number of losses: 47; Total Number of normals: 399.  

 

Somatic mutations of USP1:

 

Generating mutation plots.

 

Highly correlated genes for USP1:

 

Showing top 20/1506 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
USP1RAD180.83701303
USP1FBXO330.805507303
USP1COMMD70.786445303
USP1DUS3L0.781209303
USP1BAG60.777384303
USP1DEK0.77378413012
USP1NAA300.760433404
USP1COPS20.757602303
USP1SWT10.744731303
USP1ALG10B0.740688303
USP1MMS22L0.738926303
USP1NOC2L0.737903303
USP1CCDC1240.736183303
USP1PUS7L0.731257403
USP1EPB41L50.730767303
USP1GPS10.728978303
USP1DNAJC190.723265303
USP1CNIH10.722808404
USP1MAGOH0.721946404
USP1STX160.721526303

For details and further investigation, click here