| Full name: RAD18 E3 ubiquitin protein ligase | Alias Symbol: RNF73 | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 56852 | HGNC ID: HGNC:18278 | Ensembl Gene: ENSG00000070950 | OMIM ID: 605256 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RAD18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAD18 | 56852 | 238670_at | 0.5651 | 0.2515 | |
| GSE26886 | RAD18 | 56852 | 238670_at | 0.2880 | 0.1146 | |
| GSE45670 | RAD18 | 56852 | 238670_at | -0.2106 | 0.1614 | |
| GSE53622 | RAD18 | 56852 | 11620 | -0.0374 | 0.6522 | |
| GSE53624 | RAD18 | 56852 | 11620 | 0.5655 | 0.0000 | |
| GSE63941 | RAD18 | 56852 | 223417_at | 0.4257 | 0.4961 | |
| GSE77861 | RAD18 | 56852 | 238670_at | -0.0394 | 0.8255 | |
| GSE97050 | RAD18 | 56852 | A_23_P121222 | 0.2979 | 0.2882 | |
| SRP007169 | RAD18 | 56852 | RNAseq | 1.1993 | 0.0420 | |
| SRP008496 | RAD18 | 56852 | RNAseq | 1.2436 | 0.0014 | |
| SRP064894 | RAD18 | 56852 | RNAseq | 0.2018 | 0.1724 | |
| SRP133303 | RAD18 | 56852 | RNAseq | 0.1810 | 0.2971 | |
| SRP159526 | RAD18 | 56852 | RNAseq | 0.0851 | 0.7257 | |
| SRP193095 | RAD18 | 56852 | RNAseq | 0.1580 | 0.1736 | |
| SRP219564 | RAD18 | 56852 | RNAseq | -0.0879 | 0.8092 | |
| TCGA | RAD18 | 56852 | RNAseq | 0.2812 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RAD18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAD18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAD18 | 56852 | 1 | 18 | 11 | |
| GSE20123 | RAD18 | 56852 | 1 | 18 | 11 | |
| GSE43470 | RAD18 | 56852 | 0 | 21 | 22 | |
| GSE46452 | RAD18 | 56852 | 2 | 17 | 40 | |
| GSE47630 | RAD18 | 56852 | 2 | 22 | 16 | |
| GSE54993 | RAD18 | 56852 | 6 | 1 | 63 | |
| GSE54994 | RAD18 | 56852 | 3 | 31 | 19 | |
| GSE60625 | RAD18 | 56852 | 5 | 0 | 6 | |
| GSE74703 | RAD18 | 56852 | 0 | 17 | 19 | |
| GSE74704 | RAD18 | 56852 | 1 | 11 | 8 | |
| TCGA | RAD18 | 56852 | 6 | 64 | 26 |
Total number of gains: 27; Total number of losses: 220; Total Number of normals: 241.
Somatic mutations of RAD18:
Generating mutation plots.
Highly correlated genes for RAD18:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAD18 | MCMBP | 0.841942 | 3 | 0 | 3 |
| RAD18 | XPO1 | 0.84074 | 3 | 0 | 3 |
| RAD18 | USP1 | 0.83701 | 3 | 0 | 3 |
| RAD18 | RPAP3 | 0.828867 | 3 | 0 | 3 |
| RAD18 | PACS1 | 0.813483 | 3 | 0 | 3 |
| RAD18 | DNASE2 | 0.800012 | 3 | 0 | 3 |
| RAD18 | ZNF317 | 0.798215 | 3 | 0 | 3 |
| RAD18 | ZDHHC16 | 0.795202 | 3 | 0 | 3 |
| RAD18 | TBRG4 | 0.791992 | 3 | 0 | 3 |
| RAD18 | CDK4 | 0.789198 | 3 | 0 | 3 |
| RAD18 | ELOF1 | 0.78873 | 3 | 0 | 3 |
| RAD18 | DPM2 | 0.787662 | 3 | 0 | 3 |
| RAD18 | ABCF2 | 0.783182 | 3 | 0 | 3 |
| RAD18 | MSH2 | 0.781392 | 3 | 0 | 3 |
| RAD18 | SMC3 | 0.781271 | 3 | 0 | 3 |
| RAD18 | DHX57 | 0.780443 | 3 | 0 | 3 |
| RAD18 | CSE1L | 0.779952 | 3 | 0 | 3 |
| RAD18 | RNF34 | 0.779717 | 3 | 0 | 3 |
| RAD18 | ORC1 | 0.778864 | 3 | 0 | 3 |
| RAD18 | RAB1B | 0.77729 | 3 | 0 | 3 |
For details and further investigation, click here
