| Full name: G protein pathway suppressor 1 | Alias Symbol: COPS1|CSN1 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 2873 | HGNC ID: HGNC:4549 | Ensembl Gene: ENSG00000169727 | OMIM ID: 601934 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GPS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPS1 | 2873 | 217782_s_at | 0.4626 | 0.2910 | |
| GSE20347 | GPS1 | 2873 | 217782_s_at | 0.1132 | 0.4789 | |
| GSE23400 | GPS1 | 2873 | 217782_s_at | 0.1650 | 0.0126 | |
| GSE26886 | GPS1 | 2873 | 217782_s_at | 0.0748 | 0.7569 | |
| GSE29001 | GPS1 | 2873 | 217782_s_at | 0.2319 | 0.3003 | |
| GSE38129 | GPS1 | 2873 | 217782_s_at | 0.1736 | 0.0854 | |
| GSE45670 | GPS1 | 2873 | 217782_s_at | 0.1808 | 0.1518 | |
| GSE53622 | GPS1 | 2873 | 75904 | 0.0258 | 0.6529 | |
| GSE53624 | GPS1 | 2873 | 75904 | -0.0390 | 0.4965 | |
| GSE63941 | GPS1 | 2873 | 217782_s_at | 1.3735 | 0.0010 | |
| GSE77861 | GPS1 | 2873 | 217782_s_at | 0.2441 | 0.2361 | |
| GSE97050 | GPS1 | 2873 | A_23_P158662 | -0.1415 | 0.6907 | |
| SRP007169 | GPS1 | 2873 | RNAseq | -0.2227 | 0.5263 | |
| SRP008496 | GPS1 | 2873 | RNAseq | -0.1793 | 0.3100 | |
| SRP064894 | GPS1 | 2873 | RNAseq | 0.7519 | 0.0047 | |
| SRP133303 | GPS1 | 2873 | RNAseq | 0.3225 | 0.0342 | |
| SRP159526 | GPS1 | 2873 | RNAseq | 0.6274 | 0.0141 | |
| SRP193095 | GPS1 | 2873 | RNAseq | 0.1294 | 0.0963 | |
| SRP219564 | GPS1 | 2873 | RNAseq | 0.0429 | 0.8829 | |
| TCGA | GPS1 | 2873 | RNAseq | 0.0446 | 0.3404 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GPS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPS1 | 2873 | 4 | 4 | 22 | |
| GSE20123 | GPS1 | 2873 | 4 | 4 | 22 | |
| GSE43470 | GPS1 | 2873 | 3 | 5 | 35 | |
| GSE46452 | GPS1 | 2873 | 34 | 0 | 25 | |
| GSE47630 | GPS1 | 2873 | 9 | 2 | 29 | |
| GSE54993 | GPS1 | 2873 | 2 | 5 | 63 | |
| GSE54994 | GPS1 | 2873 | 10 | 6 | 37 | |
| GSE60625 | GPS1 | 2873 | 6 | 0 | 5 | |
| GSE74703 | GPS1 | 2873 | 3 | 3 | 30 | |
| GSE74704 | GPS1 | 2873 | 4 | 3 | 13 | |
| TCGA | GPS1 | 2873 | 24 | 13 | 59 |
Total number of gains: 103; Total number of losses: 45; Total Number of normals: 340.
Somatic mutations of GPS1:
Generating mutation plots.
Highly correlated genes for GPS1:
Showing top 20/638 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPS1 | MRPL38 | 0.755657 | 7 | 0 | 7 |
| GPS1 | USP1 | 0.728978 | 3 | 0 | 3 |
| GPS1 | RPS19BP1 | 0.722047 | 3 | 0 | 3 |
| GPS1 | LSM10 | 0.716282 | 4 | 0 | 3 |
| GPS1 | FAM83F | 0.704319 | 3 | 0 | 3 |
| GPS1 | DAG1 | 0.701775 | 3 | 0 | 3 |
| GPS1 | CSTF2T | 0.698699 | 3 | 0 | 3 |
| GPS1 | PTPN1 | 0.692602 | 3 | 0 | 3 |
| GPS1 | MBOAT1 | 0.688142 | 3 | 0 | 3 |
| GPS1 | JUP | 0.684852 | 3 | 0 | 3 |
| GPS1 | SSBP4 | 0.681627 | 3 | 0 | 3 |
| GPS1 | FAM192A | 0.678975 | 4 | 0 | 4 |
| GPS1 | SFXN2 | 0.678211 | 3 | 0 | 3 |
| GPS1 | STK11IP | 0.678174 | 3 | 0 | 3 |
| GPS1 | PKM | 0.677909 | 4 | 0 | 3 |
| GPS1 | RNF2 | 0.677157 | 3 | 0 | 3 |
| GPS1 | GGN | 0.672663 | 3 | 0 | 3 |
| GPS1 | MAP3K13 | 0.672162 | 3 | 0 | 3 |
| GPS1 | MAD2L2 | 0.669305 | 4 | 0 | 3 |
| GPS1 | SIN3A | 0.666946 | 3 | 0 | 3 |
For details and further investigation, click here
