| Full name: COP9 signalosome subunit 2 | Alias Symbol: TRIP15|ALIEN|CSN2 | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 9318 | HGNC ID: HGNC:30747 | Ensembl Gene: ENSG00000166200 | OMIM ID: 604508 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of COPS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPS2 | 9318 | 202467_s_at | -0.3577 | 0.2886 | |
| GSE20347 | COPS2 | 9318 | 202467_s_at | -0.1081 | 0.5394 | |
| GSE23400 | COPS2 | 9318 | 202467_s_at | 0.1015 | 0.2365 | |
| GSE26886 | COPS2 | 9318 | 202467_s_at | -0.0093 | 0.9671 | |
| GSE29001 | COPS2 | 9318 | 202467_s_at | -0.1663 | 0.6193 | |
| GSE38129 | COPS2 | 9318 | 202467_s_at | -0.0380 | 0.8077 | |
| GSE45670 | COPS2 | 9318 | 202467_s_at | -0.2509 | 0.0319 | |
| GSE53622 | COPS2 | 9318 | 62418 | 0.0291 | 0.6275 | |
| GSE53624 | COPS2 | 9318 | 62418 | 0.0581 | 0.1805 | |
| GSE63941 | COPS2 | 9318 | 202467_s_at | 0.0432 | 0.9205 | |
| GSE77861 | COPS2 | 9318 | 202467_s_at | -0.0380 | 0.9146 | |
| GSE97050 | COPS2 | 9318 | A_23_P26021 | -0.0522 | 0.8198 | |
| SRP007169 | COPS2 | 9318 | RNAseq | -0.6238 | 0.1206 | |
| SRP008496 | COPS2 | 9318 | RNAseq | -0.6050 | 0.0067 | |
| SRP064894 | COPS2 | 9318 | RNAseq | -0.4609 | 0.0076 | |
| SRP133303 | COPS2 | 9318 | RNAseq | 0.1543 | 0.3035 | |
| SRP159526 | COPS2 | 9318 | RNAseq | -0.3679 | 0.2671 | |
| SRP193095 | COPS2 | 9318 | RNAseq | -0.3430 | 0.0049 | |
| SRP219564 | COPS2 | 9318 | RNAseq | -0.5215 | 0.0717 | |
| TCGA | COPS2 | 9318 | RNAseq | 0.0151 | 0.7357 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COPS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COPS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPS2 | 9318 | 5 | 3 | 22 | |
| GSE20123 | COPS2 | 9318 | 5 | 3 | 22 | |
| GSE43470 | COPS2 | 9318 | 5 | 4 | 34 | |
| GSE46452 | COPS2 | 9318 | 3 | 7 | 49 | |
| GSE47630 | COPS2 | 9318 | 8 | 10 | 22 | |
| GSE54993 | COPS2 | 9318 | 4 | 6 | 60 | |
| GSE54994 | COPS2 | 9318 | 5 | 7 | 41 | |
| GSE60625 | COPS2 | 9318 | 4 | 0 | 7 | |
| GSE74703 | COPS2 | 9318 | 5 | 3 | 28 | |
| GSE74704 | COPS2 | 9318 | 2 | 3 | 15 | |
| TCGA | COPS2 | 9318 | 9 | 16 | 71 |
Total number of gains: 55; Total number of losses: 62; Total Number of normals: 371.
Somatic mutations of COPS2:
Generating mutation plots.
Highly correlated genes for COPS2:
Showing top 20/518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPS2 | UBE2N | 0.82622 | 3 | 0 | 3 |
| COPS2 | SDHD | 0.794967 | 4 | 0 | 4 |
| COPS2 | UBQLN1 | 0.786735 | 3 | 0 | 3 |
| COPS2 | MRPL30 | 0.772474 | 3 | 0 | 3 |
| COPS2 | ACRBP | 0.771686 | 3 | 0 | 3 |
| COPS2 | TRIM44 | 0.768207 | 3 | 0 | 3 |
| COPS2 | LAPTM4A | 0.766926 | 4 | 0 | 4 |
| COPS2 | ALG13 | 0.763198 | 3 | 0 | 3 |
| COPS2 | STXBP3 | 0.759754 | 3 | 0 | 3 |
| COPS2 | USP1 | 0.757602 | 3 | 0 | 3 |
| COPS2 | ZNF79 | 0.754879 | 3 | 0 | 3 |
| COPS2 | ZC3H15 | 0.748994 | 3 | 0 | 3 |
| COPS2 | CBLL1 | 0.747855 | 3 | 0 | 3 |
| COPS2 | ZNF655 | 0.742884 | 3 | 0 | 3 |
| COPS2 | TM9SF3 | 0.738705 | 3 | 0 | 3 |
| COPS2 | SNX18 | 0.729531 | 3 | 0 | 3 |
| COPS2 | GSTZ1 | 0.7228 | 3 | 0 | 3 |
| COPS2 | MRPS15 | 0.71834 | 4 | 0 | 3 |
| COPS2 | UQCRFS1 | 0.717021 | 3 | 0 | 3 |
| COPS2 | RHBDD1 | 0.715742 | 3 | 0 | 3 |
For details and further investigation, click here
