| Full name: DEK proto-oncogene | Alias Symbol: D6S231E | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 7913 | HGNC ID: HGNC:2768 | Ensembl Gene: ENSG00000124795 | OMIM ID: 125264 |
| Drug and gene relationship at DGIdb | |||
Expression of DEK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEK | 7913 | 200934_at | 0.4343 | 0.1802 | |
| GSE20347 | DEK | 7913 | 200934_at | 0.6450 | 0.0002 | |
| GSE23400 | DEK | 7913 | 200934_at | 0.9216 | 0.0000 | |
| GSE26886 | DEK | 7913 | 200934_at | 0.2656 | 0.0821 | |
| GSE29001 | DEK | 7913 | 200934_at | 0.8727 | 0.0062 | |
| GSE38129 | DEK | 7913 | 200934_at | 0.5962 | 0.0000 | |
| GSE45670 | DEK | 7913 | 200934_at | 0.1822 | 0.3409 | |
| GSE53622 | DEK | 7913 | 65913 | 0.6553 | 0.0000 | |
| GSE53624 | DEK | 7913 | 65913 | 0.9468 | 0.0000 | |
| GSE63941 | DEK | 7913 | 200934_at | 1.3715 | 0.0001 | |
| GSE77861 | DEK | 7913 | 200934_at | 0.3897 | 0.2071 | |
| GSE97050 | DEK | 7913 | A_23_P254702 | 0.1923 | 0.5210 | |
| SRP007169 | DEK | 7913 | RNAseq | 1.2023 | 0.0006 | |
| SRP008496 | DEK | 7913 | RNAseq | 1.1571 | 0.0000 | |
| SRP064894 | DEK | 7913 | RNAseq | 0.6750 | 0.0043 | |
| SRP133303 | DEK | 7913 | RNAseq | 0.8081 | 0.0000 | |
| SRP159526 | DEK | 7913 | RNAseq | 0.6829 | 0.0355 | |
| SRP193095 | DEK | 7913 | RNAseq | 0.4231 | 0.0021 | |
| SRP219564 | DEK | 7913 | RNAseq | 0.1736 | 0.5573 | |
| TCGA | DEK | 7913 | RNAseq | 0.1749 | 0.0002 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DEK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEK | 7913 | 2 | 6 | 22 | |
| GSE20123 | DEK | 7913 | 2 | 6 | 22 | |
| GSE43470 | DEK | 7913 | 9 | 0 | 34 | |
| GSE46452 | DEK | 7913 | 1 | 10 | 48 | |
| GSE47630 | DEK | 7913 | 8 | 6 | 26 | |
| GSE54993 | DEK | 7913 | 1 | 1 | 68 | |
| GSE54994 | DEK | 7913 | 10 | 4 | 39 | |
| GSE60625 | DEK | 7913 | 0 | 1 | 10 | |
| GSE74703 | DEK | 7913 | 8 | 0 | 28 | |
| GSE74704 | DEK | 7913 | 1 | 2 | 17 | |
| TCGA | DEK | 7913 | 16 | 26 | 54 |
Total number of gains: 58; Total number of losses: 62; Total Number of normals: 368.
Somatic mutations of DEK:
Generating mutation plots.
Highly correlated genes for DEK:
Showing top 20/1660 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEK | ALMS1 | 0.827946 | 3 | 0 | 3 |
| DEK | RAB34 | 0.793487 | 3 | 0 | 3 |
| DEK | BAG6 | 0.788319 | 3 | 0 | 3 |
| DEK | TRUB1 | 0.782381 | 3 | 0 | 3 |
| DEK | NAA30 | 0.779804 | 3 | 0 | 3 |
| DEK | USP1 | 0.773784 | 13 | 0 | 12 |
| DEK | AURKAIP1 | 0.769157 | 3 | 0 | 3 |
| DEK | NF1 | 0.768641 | 3 | 0 | 3 |
| DEK | GMNN | 0.764273 | 13 | 0 | 13 |
| DEK | MMS22L | 0.753599 | 3 | 0 | 3 |
| DEK | XPO1 | 0.75093 | 12 | 0 | 11 |
| DEK | SMARCC1 | 0.750506 | 3 | 0 | 3 |
| DEK | DAZAP1 | 0.744727 | 3 | 0 | 3 |
| DEK | SYNGR3 | 0.738045 | 3 | 0 | 3 |
| DEK | ZNF496 | 0.737086 | 4 | 0 | 4 |
| DEK | MCM3 | 0.73171 | 12 | 0 | 12 |
| DEK | HNRNPR | 0.729448 | 13 | 0 | 12 |
| DEK | ZNF354B | 0.723763 | 3 | 0 | 3 |
| DEK | ANAPC1 | 0.722662 | 3 | 0 | 3 |
| DEK | RFC4 | 0.721035 | 12 | 0 | 12 |
For details and further investigation, click here
