| Full name: ubiquitin specific peptidase 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.2 | ||
| Entrez ID: 7874 | HGNC ID: HGNC:12630 | Ensembl Gene: ENSG00000187555 | OMIM ID: 602519 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
USP7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection | |
| hsa05169 | Epstein-Barr virus infection |
Expression of USP7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP7 | 7874 | 201499_s_at | -0.0471 | 0.9385 | |
| GSE20347 | USP7 | 7874 | 201498_at | -0.1730 | 0.1680 | |
| GSE23400 | USP7 | 7874 | 201499_s_at | -0.2279 | 0.0002 | |
| GSE26886 | USP7 | 7874 | 201498_at | -0.2517 | 0.2277 | |
| GSE29001 | USP7 | 7874 | 201498_at | -0.0159 | 0.9525 | |
| GSE38129 | USP7 | 7874 | 201498_at | -0.1254 | 0.3335 | |
| GSE45670 | USP7 | 7874 | 201498_at | -0.0012 | 0.9937 | |
| GSE53622 | USP7 | 7874 | 27859 | -0.3087 | 0.0000 | |
| GSE53624 | USP7 | 7874 | 27859 | -0.2553 | 0.0000 | |
| GSE63941 | USP7 | 7874 | 201499_s_at | 0.6371 | 0.0517 | |
| GSE77861 | USP7 | 7874 | 201499_s_at | -0.1453 | 0.5237 | |
| GSE97050 | USP7 | 7874 | A_24_P245108 | -0.3402 | 0.2307 | |
| SRP007169 | USP7 | 7874 | RNAseq | -0.4487 | 0.1392 | |
| SRP008496 | USP7 | 7874 | RNAseq | -0.2786 | 0.1140 | |
| SRP064894 | USP7 | 7874 | RNAseq | -0.5902 | 0.0001 | |
| SRP133303 | USP7 | 7874 | RNAseq | -0.0205 | 0.8723 | |
| SRP159526 | USP7 | 7874 | RNAseq | -0.1200 | 0.6938 | |
| SRP193095 | USP7 | 7874 | RNAseq | -0.2132 | 0.0038 | |
| SRP219564 | USP7 | 7874 | RNAseq | -0.3464 | 0.1007 | |
| TCGA | USP7 | 7874 | RNAseq | 0.0209 | 0.6148 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by USP7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP7 | 7874 | 4 | 4 | 22 | |
| GSE20123 | USP7 | 7874 | 4 | 3 | 23 | |
| GSE43470 | USP7 | 7874 | 3 | 2 | 38 | |
| GSE46452 | USP7 | 7874 | 38 | 1 | 20 | |
| GSE47630 | USP7 | 7874 | 13 | 6 | 21 | |
| GSE54993 | USP7 | 7874 | 3 | 5 | 62 | |
| GSE54994 | USP7 | 7874 | 5 | 9 | 39 | |
| GSE60625 | USP7 | 7874 | 4 | 0 | 7 | |
| GSE74703 | USP7 | 7874 | 3 | 2 | 31 | |
| GSE74704 | USP7 | 7874 | 2 | 1 | 17 | |
| TCGA | USP7 | 7874 | 21 | 12 | 63 |
Total number of gains: 100; Total number of losses: 45; Total Number of normals: 343.
Somatic mutations of USP7:
Generating mutation plots.
Highly correlated genes for USP7:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP7 | BTBD10 | 0.663224 | 3 | 0 | 3 |
| USP7 | NPAS3 | 0.661559 | 3 | 0 | 3 |
| USP7 | PEX11A | 0.633679 | 3 | 0 | 3 |
| USP7 | NDST2 | 0.619732 | 4 | 0 | 4 |
| USP7 | ZNF30 | 0.618497 | 3 | 0 | 3 |
| USP7 | MIEF2 | 0.613441 | 3 | 0 | 3 |
| USP7 | KRAS | 0.608141 | 4 | 0 | 4 |
| USP7 | MOB2 | 0.597327 | 4 | 0 | 3 |
| USP7 | NUDT7 | 0.597146 | 3 | 0 | 3 |
| USP7 | TOLLIP | 0.596848 | 6 | 0 | 6 |
| USP7 | METTL9 | 0.594337 | 5 | 0 | 3 |
| USP7 | FRAT1 | 0.587805 | 4 | 0 | 3 |
| USP7 | TALDO1 | 0.586546 | 4 | 0 | 3 |
| USP7 | THUMPD1 | 0.577328 | 4 | 0 | 3 |
| USP7 | ITGB1BP2 | 0.574798 | 4 | 0 | 3 |
| USP7 | MYCL | 0.573107 | 4 | 0 | 3 |
| USP7 | EEA1 | 0.555679 | 4 | 0 | 3 |
| USP7 | NUDT16L1 | 0.552588 | 4 | 0 | 3 |
| USP7 | DCTN5 | 0.545035 | 6 | 0 | 3 |
| USP7 | ZNF264 | 0.542712 | 5 | 0 | 4 |
For details and further investigation, click here
