KRAS

 

Full name: KRAS proto-oncogene, GTPase Alias Symbol: KRAS1
Type: protein-coding gene Cytoband: 12p12.1
Entrez ID: 3845 HGNC ID: HGNC:6407 Ensembl Gene: ENSG00000133703 OMIM ID: 190070
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 84/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

KRAS involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04530Tight junction
hsa04540Gap junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04960Aldosterone-regulated sodium reabsorption
hsa05034Alcoholism
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of KRAS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KRAS 3845 204009_s_at -0.1116 0.8563
GSE20347 KRAS 3845 214352_s_at -0.2528 0.2578
GSE23400 KRAS 3845 204009_s_at -0.0730 0.4859
GSE26886 KRAS 3845 204009_s_at -0.7191 0.0030
GSE29001 KRAS 3845 204009_s_at -0.1544 0.4241
GSE38129 KRAS 3845 214352_s_at -0.2236 0.5252
GSE45670 KRAS 3845 204009_s_at -0.0469 0.8183
GSE53622 KRAS 3845 148548 -0.5233 0.0000
GSE53624 KRAS 3845 148548 -0.6472 0.0000
GSE63941 KRAS 3845 204009_s_at 0.0524 0.9334
GSE77861 KRAS 3845 204009_s_at 0.0102 0.9705
GSE97050 KRAS 3845 A_33_P3317815 -0.4306 0.1581
SRP007169 KRAS 3845 RNAseq -0.7009 0.0288
SRP008496 KRAS 3845 RNAseq -0.3943 0.0605
SRP064894 KRAS 3845 RNAseq -0.6533 0.0069
SRP133303 KRAS 3845 RNAseq 0.2237 0.1573
SRP159526 KRAS 3845 RNAseq -0.4376 0.0647
SRP193095 KRAS 3845 RNAseq -0.5363 0.0000
SRP219564 KRAS 3845 RNAseq -0.7799 0.0165
TCGA KRAS 3845 RNAseq -0.0708 0.2039

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KRAS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KRAS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KRAS 3845 10 1 19
GSE20123 KRAS 3845 10 1 19
GSE43470 KRAS 3845 9 4 30
GSE46452 KRAS 3845 10 1 48
GSE47630 KRAS 3845 15 0 25
GSE54993 KRAS 3845 0 9 61
GSE54994 KRAS 3845 11 2 40
GSE60625 KRAS 3845 0 1 10
GSE74703 KRAS 3845 9 3 24
GSE74704 KRAS 3845 6 1 13
TCGA KRAS 3845 43 4 49

Total number of gains: 123; Total number of losses: 27; Total Number of normals: 338.  

 

Somatic mutations of KRAS:

 

Generating mutation plots.

 

Highly correlated genes for KRAS:

 

Showing top 20/691 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KRASUBE2NL0.758453303
KRASGGA30.752025303
KRASCHD90.747546303
KRASLETMD10.740568303
KRASSENP80.7305303
KRASCBLL10.730087303
KRASEXOC40.725709303
KRASINSIG10.715505303
KRASING40.712718403
KRASEPG50.712315303
KRASPIK3C30.70869303
KRASSREBF20.706521303
KRASARL5B0.705643303
KRASKCTD150.705266303
KRASPRPF38A0.700359303
KRASCWC250.698776303
KRASCS0.697475404
KRASCTTNBP2NL0.693627505
KRASCPEB40.692647505
KRASCOX5A0.692602403

For details and further investigation, click here