| Full name: early endosome antigen 1 | Alias Symbol: ZFYVE2 | ||
| Type: protein-coding gene | Cytoband: 12q22 | ||
| Entrez ID: 8411 | HGNC ID: HGNC:3185 | Ensembl Gene: ENSG00000102189 | OMIM ID: 605070 |
| Drug and gene relationship at DGIdb | |||
EEA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05152 | Tuberculosis |
Expression of EEA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EEA1 | 8411 | 225885_at | -0.7633 | 0.2193 | |
| GSE20347 | EEA1 | 8411 | 204841_s_at | -0.4003 | 0.0046 | |
| GSE23400 | EEA1 | 8411 | 204841_s_at | -0.0659 | 0.1941 | |
| GSE26886 | EEA1 | 8411 | 225885_at | -1.1579 | 0.0003 | |
| GSE29001 | EEA1 | 8411 | 204841_s_at | -0.5491 | 0.0542 | |
| GSE38129 | EEA1 | 8411 | 204841_s_at | -0.2569 | 0.1348 | |
| GSE45670 | EEA1 | 8411 | 225885_at | -0.5248 | 0.0055 | |
| GSE53622 | EEA1 | 8411 | 65205 | -0.8451 | 0.0000 | |
| GSE53624 | EEA1 | 8411 | 65205 | -0.9962 | 0.0000 | |
| GSE63941 | EEA1 | 8411 | 225885_at | -2.4673 | 0.0037 | |
| GSE77861 | EEA1 | 8411 | 225885_at | -1.1808 | 0.0148 | |
| GSE97050 | EEA1 | 8411 | A_23_P76159 | -0.3158 | 0.2196 | |
| SRP007169 | EEA1 | 8411 | RNAseq | -0.9841 | 0.0072 | |
| SRP008496 | EEA1 | 8411 | RNAseq | -0.7167 | 0.0004 | |
| SRP064894 | EEA1 | 8411 | RNAseq | -0.9873 | 0.0011 | |
| SRP133303 | EEA1 | 8411 | RNAseq | -0.6201 | 0.0003 | |
| SRP159526 | EEA1 | 8411 | RNAseq | -1.0372 | 0.0104 | |
| SRP193095 | EEA1 | 8411 | RNAseq | -0.8459 | 0.0000 | |
| SRP219564 | EEA1 | 8411 | RNAseq | -0.9774 | 0.0179 | |
| TCGA | EEA1 | 8411 | RNAseq | -0.0326 | 0.6230 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by EEA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EEA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EEA1 | 8411 | 3 | 2 | 25 | |
| GSE20123 | EEA1 | 8411 | 3 | 2 | 25 | |
| GSE43470 | EEA1 | 8411 | 3 | 0 | 40 | |
| GSE46452 | EEA1 | 8411 | 9 | 1 | 49 | |
| GSE47630 | EEA1 | 8411 | 10 | 1 | 29 | |
| GSE54993 | EEA1 | 8411 | 0 | 6 | 64 | |
| GSE54994 | EEA1 | 8411 | 6 | 1 | 46 | |
| GSE60625 | EEA1 | 8411 | 0 | 0 | 11 | |
| GSE74703 | EEA1 | 8411 | 3 | 0 | 33 | |
| GSE74704 | EEA1 | 8411 | 1 | 2 | 17 | |
| TCGA | EEA1 | 8411 | 18 | 10 | 68 |
Total number of gains: 56; Total number of losses: 25; Total Number of normals: 407.
Somatic mutations of EEA1:
Generating mutation plots.
Highly correlated genes for EEA1:
Showing top 20/1581 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EEA1 | IMPACT | 0.818385 | 3 | 0 | 3 |
| EEA1 | MNS1 | 0.800216 | 3 | 0 | 3 |
| EEA1 | ESYT2 | 0.7892 | 4 | 0 | 4 |
| EEA1 | COPG2 | 0.786473 | 3 | 0 | 3 |
| EEA1 | S100A16 | 0.785601 | 6 | 0 | 6 |
| EEA1 | GBP6 | 0.779063 | 4 | 0 | 4 |
| EEA1 | SMIM14 | 0.768538 | 5 | 0 | 5 |
| EEA1 | ZNF823 | 0.763995 | 7 | 0 | 7 |
| EEA1 | NKTR | 0.762895 | 3 | 0 | 3 |
| EEA1 | TMX3 | 0.757462 | 3 | 0 | 3 |
| EEA1 | TRIM6 | 0.753402 | 7 | 0 | 7 |
| EEA1 | IKZF2 | 0.747546 | 7 | 0 | 7 |
| EEA1 | CA13 | 0.747025 | 3 | 0 | 3 |
| EEA1 | CAST | 0.745179 | 10 | 0 | 10 |
| EEA1 | TAB3 | 0.744053 | 8 | 0 | 8 |
| EEA1 | FAM122A | 0.743872 | 4 | 0 | 4 |
| EEA1 | PRKAR2A | 0.743347 | 8 | 0 | 6 |
| EEA1 | FCHO2 | 0.74224 | 8 | 0 | 7 |
| EEA1 | BCS1L | 0.742235 | 3 | 0 | 3 |
| EEA1 | FIBIN | 0.738142 | 3 | 0 | 3 |
For details and further investigation, click here
