| Full name: toll interacting protein | Alias Symbol: IL-1RAcPIP | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 54472 | HGNC ID: HGNC:16476 | Ensembl Gene: ENSG00000078902 | OMIM ID: 606277 |
| Drug and gene relationship at DGIdb | |||
TOLLIP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
Expression of TOLLIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOLLIP | 54472 | 217930_s_at | -0.5501 | 0.3993 | |
| GSE20347 | TOLLIP | 54472 | 217930_s_at | -1.3056 | 0.0000 | |
| GSE23400 | TOLLIP | 54472 | 217930_s_at | -0.8404 | 0.0000 | |
| GSE26886 | TOLLIP | 54472 | 222469_s_at | -1.1241 | 0.0000 | |
| GSE29001 | TOLLIP | 54472 | 217930_s_at | -0.9564 | 0.0021 | |
| GSE38129 | TOLLIP | 54472 | 217930_s_at | -0.8671 | 0.0000 | |
| GSE45670 | TOLLIP | 54472 | 217930_s_at | -0.3868 | 0.0518 | |
| GSE53622 | TOLLIP | 54472 | 18507 | -0.7243 | 0.0000 | |
| GSE53624 | TOLLIP | 54472 | 18507 | -0.8671 | 0.0000 | |
| GSE63941 | TOLLIP | 54472 | 217930_s_at | 0.2847 | 0.4223 | |
| GSE77861 | TOLLIP | 54472 | 217930_s_at | -0.6104 | 0.0392 | |
| GSE97050 | TOLLIP | 54472 | A_33_P3385101 | -0.3329 | 0.2657 | |
| SRP007169 | TOLLIP | 54472 | RNAseq | -2.1247 | 0.0000 | |
| SRP008496 | TOLLIP | 54472 | RNAseq | -1.9765 | 0.0000 | |
| SRP064894 | TOLLIP | 54472 | RNAseq | -1.0055 | 0.0000 | |
| SRP133303 | TOLLIP | 54472 | RNAseq | -0.9374 | 0.0000 | |
| SRP159526 | TOLLIP | 54472 | RNAseq | -1.5544 | 0.0000 | |
| SRP193095 | TOLLIP | 54472 | RNAseq | -1.1601 | 0.0000 | |
| SRP219564 | TOLLIP | 54472 | RNAseq | -1.0878 | 0.0007 | |
| TCGA | TOLLIP | 54472 | RNAseq | -0.1321 | 0.0363 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by TOLLIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOLLIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOLLIP | 54472 | 1 | 11 | 18 | |
| GSE20123 | TOLLIP | 54472 | 1 | 12 | 17 | |
| GSE43470 | TOLLIP | 54472 | 1 | 10 | 32 | |
| GSE46452 | TOLLIP | 54472 | 7 | 8 | 44 | |
| GSE47630 | TOLLIP | 54472 | 4 | 12 | 24 | |
| GSE54993 | TOLLIP | 54472 | 3 | 1 | 66 | |
| GSE54994 | TOLLIP | 54472 | 1 | 12 | 40 | |
| GSE60625 | TOLLIP | 54472 | 0 | 0 | 11 | |
| GSE74703 | TOLLIP | 54472 | 1 | 8 | 27 | |
| GSE74704 | TOLLIP | 54472 | 0 | 8 | 12 | |
| TCGA | TOLLIP | 54472 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of TOLLIP:
Generating mutation plots.
Highly correlated genes for TOLLIP:
Showing top 20/1523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOLLIP | RNF141 | 0.824913 | 10 | 0 | 10 |
| TOLLIP | TMEM9B | 0.798107 | 10 | 0 | 10 |
| TOLLIP | PDCD6IP | 0.791766 | 10 | 0 | 10 |
| TOLLIP | EPS8L2 | 0.778325 | 11 | 0 | 10 |
| TOLLIP | IL18 | 0.775422 | 10 | 0 | 10 |
| TOLLIP | ABHD5 | 0.77094 | 9 | 0 | 9 |
| TOLLIP | C6orf132 | 0.770266 | 6 | 0 | 6 |
| TOLLIP | EVPL | 0.769074 | 11 | 0 | 10 |
| TOLLIP | FAM180B | 0.767204 | 3 | 0 | 3 |
| TOLLIP | S100A16 | 0.766799 | 7 | 0 | 7 |
| TOLLIP | OSTF1 | 0.766339 | 10 | 0 | 10 |
| TOLLIP | PRSS3 | 0.76558 | 10 | 0 | 10 |
| TOLLIP | UBL3 | 0.76407 | 11 | 0 | 11 |
| TOLLIP | MFSD5 | 0.76381 | 11 | 0 | 10 |
| TOLLIP | CCNYL1 | 0.756661 | 4 | 0 | 4 |
| TOLLIP | BTBD11 | 0.756199 | 6 | 0 | 6 |
| TOLLIP | TMED3 | 0.753945 | 10 | 0 | 9 |
| TOLLIP | SLK | 0.753054 | 10 | 0 | 9 |
| TOLLIP | TGM1 | 0.752863 | 11 | 0 | 10 |
| TOLLIP | SULT2B1 | 0.752584 | 9 | 0 | 8 |
For details and further investigation, click here
