| Full name: VPS33A core subunit of CORVET and HOPS complexes | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 65082 | HGNC ID: HGNC:18179 | Ensembl Gene: ENSG00000139719 | OMIM ID: 610034 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of VPS33A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS33A | 65082 | 227815_at | 0.2587 | 0.5948 | |
| GSE20347 | VPS33A | 65082 | 204590_x_at | -0.0041 | 0.9716 | |
| GSE23400 | VPS33A | 65082 | 204590_x_at | -0.0226 | 0.4961 | |
| GSE26886 | VPS33A | 65082 | 227815_at | 0.3174 | 0.1406 | |
| GSE29001 | VPS33A | 65082 | 204590_x_at | -0.2143 | 0.1940 | |
| GSE38129 | VPS33A | 65082 | 204590_x_at | -0.0218 | 0.7987 | |
| GSE45670 | VPS33A | 65082 | 227815_at | 0.0420 | 0.7899 | |
| GSE53622 | VPS33A | 65082 | 74410 | 0.3411 | 0.0000 | |
| GSE53624 | VPS33A | 65082 | 74410 | 0.2670 | 0.0000 | |
| GSE63941 | VPS33A | 65082 | 227815_at | -0.1864 | 0.5866 | |
| GSE77861 | VPS33A | 65082 | 227815_at | 0.0369 | 0.7894 | |
| GSE97050 | VPS33A | 65082 | A_23_P36408 | 0.4108 | 0.1474 | |
| SRP007169 | VPS33A | 65082 | RNAseq | 0.3924 | 0.3348 | |
| SRP008496 | VPS33A | 65082 | RNAseq | 0.4137 | 0.2205 | |
| SRP064894 | VPS33A | 65082 | RNAseq | 0.2382 | 0.0073 | |
| SRP133303 | VPS33A | 65082 | RNAseq | 0.1919 | 0.0628 | |
| SRP159526 | VPS33A | 65082 | RNAseq | 0.2186 | 0.3357 | |
| SRP193095 | VPS33A | 65082 | RNAseq | 0.0491 | 0.4125 | |
| SRP219564 | VPS33A | 65082 | RNAseq | 0.1147 | 0.5764 | |
| TCGA | VPS33A | 65082 | RNAseq | 0.0405 | 0.4430 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS33A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS33A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS33A | 65082 | 5 | 4 | 21 | |
| GSE20123 | VPS33A | 65082 | 5 | 4 | 21 | |
| GSE43470 | VPS33A | 65082 | 2 | 2 | 39 | |
| GSE46452 | VPS33A | 65082 | 9 | 1 | 49 | |
| GSE47630 | VPS33A | 65082 | 9 | 3 | 28 | |
| GSE54993 | VPS33A | 65082 | 0 | 5 | 65 | |
| GSE54994 | VPS33A | 65082 | 5 | 7 | 41 | |
| GSE60625 | VPS33A | 65082 | 0 | 0 | 11 | |
| GSE74703 | VPS33A | 65082 | 2 | 1 | 33 | |
| GSE74704 | VPS33A | 65082 | 4 | 2 | 14 | |
| TCGA | VPS33A | 65082 | 21 | 10 | 65 |
Total number of gains: 62; Total number of losses: 39; Total Number of normals: 387.
Somatic mutations of VPS33A:
Generating mutation plots.
Highly correlated genes for VPS33A:
Showing top 20/456 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS33A | RSBN1L | 0.796554 | 3 | 0 | 3 |
| VPS33A | NUP54 | 0.751988 | 3 | 0 | 3 |
| VPS33A | SRP54 | 0.751293 | 3 | 0 | 3 |
| VPS33A | FARSA | 0.732894 | 4 | 0 | 4 |
| VPS33A | R3HDM2 | 0.732358 | 3 | 0 | 3 |
| VPS33A | NAA10 | 0.729519 | 3 | 0 | 3 |
| VPS33A | MCMBP | 0.729513 | 3 | 0 | 3 |
| VPS33A | CEP41 | 0.728295 | 4 | 0 | 4 |
| VPS33A | CLP1 | 0.725153 | 4 | 0 | 3 |
| VPS33A | CELSR2 | 0.725009 | 3 | 0 | 3 |
| VPS33A | SGMS1 | 0.714995 | 4 | 0 | 3 |
| VPS33A | EID2 | 0.712327 | 3 | 0 | 3 |
| VPS33A | KTI12 | 0.711493 | 3 | 0 | 3 |
| VPS33A | EFHC1 | 0.71069 | 3 | 0 | 3 |
| VPS33A | PIGK | 0.710318 | 3 | 0 | 3 |
| VPS33A | GTF3C4 | 0.704278 | 5 | 0 | 5 |
| VPS33A | ZFC3H1 | 0.699986 | 3 | 0 | 3 |
| VPS33A | TTC26 | 0.699465 | 4 | 0 | 3 |
| VPS33A | ABCB10 | 0.69864 | 3 | 0 | 3 |
| VPS33A | NAIF1 | 0.697859 | 4 | 0 | 4 |
For details and further investigation, click here
