| Full name: cadherin EGF LAG seven-pass G-type receptor 2 | Alias Symbol: KIAA0279|MEGF3|Flamingo1|CDHF10|ADGRC2 | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 1952 | HGNC ID: HGNC:3231 | Ensembl Gene: ENSG00000143126 | OMIM ID: 604265 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CELSR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CELSR2 | 1952 | 36499_at | 0.2811 | 0.7415 | |
| GSE20347 | CELSR2 | 1952 | 36499_at | -0.5012 | 0.0013 | |
| GSE23400 | CELSR2 | 1952 | 204029_at | 0.0042 | 0.9666 | |
| GSE26886 | CELSR2 | 1952 | 36499_at | -0.4077 | 0.1215 | |
| GSE29001 | CELSR2 | 1952 | 36499_at | 0.0944 | 0.7491 | |
| GSE38129 | CELSR2 | 1952 | 36499_at | 0.0398 | 0.9001 | |
| GSE45670 | CELSR2 | 1952 | 36499_at | 0.3369 | 0.0665 | |
| GSE53622 | CELSR2 | 1952 | 12454 | 0.1327 | 0.4234 | |
| GSE53624 | CELSR2 | 1952 | 12454 | 0.1439 | 0.1856 | |
| GSE63941 | CELSR2 | 1952 | 36499_at | 2.4528 | 0.0013 | |
| GSE77861 | CELSR2 | 1952 | 36499_at | 0.1900 | 0.4053 | |
| GSE97050 | CELSR2 | 1952 | A_24_P182620 | 0.4319 | 0.1937 | |
| SRP007169 | CELSR2 | 1952 | RNAseq | 1.2617 | 0.0600 | |
| SRP008496 | CELSR2 | 1952 | RNAseq | 0.4986 | 0.2753 | |
| SRP064894 | CELSR2 | 1952 | RNAseq | -0.0844 | 0.8165 | |
| SRP133303 | CELSR2 | 1952 | RNAseq | 0.2289 | 0.3049 | |
| SRP159526 | CELSR2 | 1952 | RNAseq | -0.0516 | 0.8976 | |
| SRP193095 | CELSR2 | 1952 | RNAseq | 0.1060 | 0.7224 | |
| SRP219564 | CELSR2 | 1952 | RNAseq | -0.4733 | 0.5107 | |
| TCGA | CELSR2 | 1952 | RNAseq | 0.3881 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CELSR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CELSR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CELSR2 | 1952 | 0 | 12 | 18 | |
| GSE20123 | CELSR2 | 1952 | 0 | 11 | 19 | |
| GSE43470 | CELSR2 | 1952 | 0 | 8 | 35 | |
| GSE46452 | CELSR2 | 1952 | 2 | 1 | 56 | |
| GSE47630 | CELSR2 | 1952 | 9 | 5 | 26 | |
| GSE54993 | CELSR2 | 1952 | 0 | 1 | 69 | |
| GSE54994 | CELSR2 | 1952 | 7 | 4 | 42 | |
| GSE60625 | CELSR2 | 1952 | 0 | 0 | 11 | |
| GSE74703 | CELSR2 | 1952 | 0 | 6 | 30 | |
| GSE74704 | CELSR2 | 1952 | 0 | 7 | 13 | |
| TCGA | CELSR2 | 1952 | 9 | 26 | 61 |
Total number of gains: 27; Total number of losses: 81; Total Number of normals: 380.
Somatic mutations of CELSR2:
Generating mutation plots.
Highly correlated genes for CELSR2:
Showing top 20/443 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CELSR2 | TMEM60 | 0.770338 | 3 | 0 | 3 |
| CELSR2 | CPNE2 | 0.747834 | 3 | 0 | 3 |
| CELSR2 | TMEM44 | 0.746431 | 3 | 0 | 3 |
| CELSR2 | VPS33A | 0.725009 | 3 | 0 | 3 |
| CELSR2 | AGTRAP | 0.724893 | 3 | 0 | 3 |
| CELSR2 | ZDHHC5 | 0.724714 | 3 | 0 | 3 |
| CELSR2 | COPE | 0.724445 | 4 | 0 | 4 |
| CELSR2 | TPM3 | 0.723254 | 3 | 0 | 3 |
| CELSR2 | C1orf43 | 0.721111 | 3 | 0 | 3 |
| CELSR2 | RHBDD2 | 0.719455 | 3 | 0 | 3 |
| CELSR2 | SYNE2 | 0.718396 | 4 | 0 | 4 |
| CELSR2 | COMMD2 | 0.715606 | 3 | 0 | 3 |
| CELSR2 | SNW1 | 0.71521 | 3 | 0 | 3 |
| CELSR2 | CHCHD5 | 0.709174 | 3 | 0 | 3 |
| CELSR2 | IAH1 | 0.706856 | 4 | 0 | 4 |
| CELSR2 | SLC25A39 | 0.705779 | 4 | 0 | 4 |
| CELSR2 | SYK | 0.701922 | 5 | 0 | 4 |
| CELSR2 | NUP210 | 0.701215 | 3 | 0 | 3 |
| CELSR2 | ARMC10 | 0.697562 | 3 | 0 | 3 |
| CELSR2 | C12orf60 | 0.697033 | 3 | 0 | 3 |
For details and further investigation, click here
