| Full name: VRK serine/threonine kinase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 51231 | HGNC ID: HGNC:18996 | Ensembl Gene: ENSG00000105053 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of VRK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VRK3 | 51231 | 221998_s_at | 0.0717 | 0.9200 | |
| GSE20347 | VRK3 | 51231 | 218022_at | -0.1722 | 0.1343 | |
| GSE23400 | VRK3 | 51231 | 218022_at | -0.0368 | 0.3148 | |
| GSE26886 | VRK3 | 51231 | 218022_at | 0.0472 | 0.7655 | |
| GSE29001 | VRK3 | 51231 | 218022_at | -0.2622 | 0.0647 | |
| GSE38129 | VRK3 | 51231 | 218022_at | -0.1451 | 0.1101 | |
| GSE45670 | VRK3 | 51231 | 218022_at | 0.1711 | 0.1595 | |
| GSE53622 | VRK3 | 51231 | 90271 | -0.0568 | 0.5264 | |
| GSE53624 | VRK3 | 51231 | 90271 | -0.1362 | 0.2799 | |
| GSE63941 | VRK3 | 51231 | 221998_s_at | 1.0441 | 0.0032 | |
| GSE77861 | VRK3 | 51231 | 218022_at | -0.0982 | 0.5758 | |
| GSE97050 | VRK3 | 51231 | A_23_P107933 | 0.0302 | 0.9047 | |
| SRP007169 | VRK3 | 51231 | RNAseq | -0.4130 | 0.2432 | |
| SRP008496 | VRK3 | 51231 | RNAseq | -0.5446 | 0.0220 | |
| SRP064894 | VRK3 | 51231 | RNAseq | 0.2077 | 0.3019 | |
| SRP133303 | VRK3 | 51231 | RNAseq | 0.0911 | 0.6178 | |
| SRP159526 | VRK3 | 51231 | RNAseq | 0.1141 | 0.5151 | |
| SRP193095 | VRK3 | 51231 | RNAseq | -0.1079 | 0.3991 | |
| SRP219564 | VRK3 | 51231 | RNAseq | 0.0281 | 0.9075 | |
| TCGA | VRK3 | 51231 | RNAseq | -0.1422 | 0.0078 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by VRK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VRK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VRK3 | 51231 | 4 | 4 | 22 | |
| GSE20123 | VRK3 | 51231 | 4 | 3 | 23 | |
| GSE43470 | VRK3 | 51231 | 5 | 11 | 27 | |
| GSE46452 | VRK3 | 51231 | 45 | 1 | 13 | |
| GSE47630 | VRK3 | 51231 | 10 | 6 | 24 | |
| GSE54993 | VRK3 | 51231 | 17 | 4 | 49 | |
| GSE54994 | VRK3 | 51231 | 4 | 14 | 35 | |
| GSE60625 | VRK3 | 51231 | 9 | 0 | 2 | |
| GSE74703 | VRK3 | 51231 | 5 | 7 | 24 | |
| GSE74704 | VRK3 | 51231 | 4 | 1 | 15 | |
| TCGA | VRK3 | 51231 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of VRK3:
Generating mutation plots.
Highly correlated genes for VRK3:
Showing top 20/405 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VRK3 | ATXN7L3B | 0.829729 | 3 | 0 | 3 |
| VRK3 | ZNF227 | 0.808519 | 3 | 0 | 3 |
| VRK3 | COPE | 0.77985 | 3 | 0 | 3 |
| VRK3 | ABCA3 | 0.761114 | 3 | 0 | 3 |
| VRK3 | ELOF1 | 0.756797 | 4 | 0 | 4 |
| VRK3 | MGMT | 0.75634 | 3 | 0 | 3 |
| VRK3 | RCOR3 | 0.74525 | 3 | 0 | 3 |
| VRK3 | ATG4C | 0.744587 | 3 | 0 | 3 |
| VRK3 | ZXDC | 0.737692 | 3 | 0 | 3 |
| VRK3 | FAM104B | 0.736617 | 4 | 0 | 4 |
| VRK3 | TMEM185A | 0.736071 | 3 | 0 | 3 |
| VRK3 | NUCB1 | 0.735294 | 5 | 0 | 5 |
| VRK3 | RPS24 | 0.734662 | 3 | 0 | 3 |
| VRK3 | TMTC4 | 0.733572 | 3 | 0 | 3 |
| VRK3 | CSNK1D | 0.727786 | 3 | 0 | 3 |
| VRK3 | ETV6 | 0.726733 | 3 | 0 | 3 |
| VRK3 | UBL5 | 0.723437 | 3 | 0 | 3 |
| VRK3 | PHF13 | 0.721271 | 3 | 0 | 3 |
| VRK3 | PROSER1 | 0.720512 | 4 | 0 | 4 |
| VRK3 | RAB4B | 0.72002 | 3 | 0 | 3 |
For details and further investigation, click here
