| Full name: coatomer protein complex subunit epsilon | Alias Symbol: epsilon-COP | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 11316 | HGNC ID: HGNC:2234 | Ensembl Gene: ENSG00000105669 | OMIM ID: 606942 |
| Drug and gene relationship at DGIdb | |||
Expression of COPE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COPE | 11316 | 201264_at | -0.0560 | 0.9080 | |
| GSE20347 | COPE | 11316 | 201264_at | -0.5490 | 0.0008 | |
| GSE23400 | COPE | 11316 | 201264_at | -0.0041 | 0.9581 | |
| GSE26886 | COPE | 11316 | 201264_at | 0.3746 | 0.3738 | |
| GSE29001 | COPE | 11316 | 201264_at | -0.1550 | 0.6967 | |
| GSE38129 | COPE | 11316 | 201264_at | -0.1706 | 0.3020 | |
| GSE45670 | COPE | 11316 | 201264_at | 0.0247 | 0.9073 | |
| GSE63941 | COPE | 11316 | 201264_at | 2.3419 | 0.0000 | |
| GSE77861 | COPE | 11316 | 201264_at | 0.0310 | 0.9198 | |
| GSE97050 | COPE | 11316 | A_24_P399622 | 0.0090 | 0.9770 | |
| SRP007169 | COPE | 11316 | RNAseq | -1.2414 | 0.0002 | |
| SRP008496 | COPE | 11316 | RNAseq | -1.2453 | 0.0000 | |
| SRP064894 | COPE | 11316 | RNAseq | 0.2840 | 0.3600 | |
| SRP133303 | COPE | 11316 | RNAseq | -0.0649 | 0.6201 | |
| SRP159526 | COPE | 11316 | RNAseq | -0.2698 | 0.1246 | |
| SRP193095 | COPE | 11316 | RNAseq | -0.3716 | 0.0004 | |
| SRP219564 | COPE | 11316 | RNAseq | 0.3552 | 0.1567 | |
| TCGA | COPE | 11316 | RNAseq | 0.0279 | 0.5488 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by COPE expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of COPE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COPE | 11316 | 4 | 5 | 21 | |
| GSE20123 | COPE | 11316 | 3 | 3 | 24 | |
| GSE43470 | COPE | 11316 | 2 | 5 | 36 | |
| GSE46452 | COPE | 11316 | 47 | 1 | 11 | |
| GSE47630 | COPE | 11316 | 5 | 8 | 27 | |
| GSE54993 | COPE | 11316 | 16 | 4 | 50 | |
| GSE54994 | COPE | 11316 | 6 | 13 | 34 | |
| GSE60625 | COPE | 11316 | 9 | 0 | 2 | |
| GSE74703 | COPE | 11316 | 2 | 3 | 31 | |
| GSE74704 | COPE | 11316 | 0 | 3 | 17 | |
| TCGA | COPE | 11316 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of COPE:
Generating mutation plots.
Highly correlated genes for COPE:
Showing top 20/513 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COPE | BSG | 0.845276 | 3 | 0 | 3 |
| COPE | SELPLG | 0.828159 | 3 | 0 | 3 |
| COPE | KLF16 | 0.804941 | 3 | 0 | 3 |
| COPE | GNG5 | 0.789964 | 3 | 0 | 3 |
| COPE | FAM131B | 0.782016 | 3 | 0 | 3 |
| COPE | VRK3 | 0.77985 | 3 | 0 | 3 |
| COPE | ZNF683 | 0.773805 | 3 | 0 | 3 |
| COPE | TNKS2 | 0.773421 | 4 | 0 | 4 |
| COPE | RECQL5 | 0.770056 | 3 | 0 | 3 |
| COPE | S1PR5 | 0.768041 | 3 | 0 | 3 |
| COPE | MRPL38 | 0.756135 | 6 | 0 | 6 |
| COPE | CDC14A | 0.754813 | 3 | 0 | 3 |
| COPE | PTPN9 | 0.750935 | 3 | 0 | 3 |
| COPE | CUL7 | 0.749183 | 4 | 0 | 4 |
| COPE | AFTPH | 0.742161 | 4 | 0 | 3 |
| COPE | ZC3H18 | 0.740734 | 3 | 0 | 3 |
| COPE | GNG7 | 0.737411 | 3 | 0 | 3 |
| COPE | RRNAD1 | 0.736771 | 3 | 0 | 3 |
| COPE | SAMD1 | 0.735524 | 4 | 0 | 4 |
| COPE | HES4 | 0.73326 | 3 | 0 | 3 |
For details and further investigation, click here
