| Full name: dedicator of cytokinesis 1 | Alias Symbol: DOCK180|ced5 | ||
| Type: protein-coding gene | Cytoband: 10q26.2 | ||
| Entrez ID: 1793 | HGNC ID: HGNC:2987 | Ensembl Gene: ENSG00000150760 | OMIM ID: 601403 |
| Drug and gene relationship at DGIdb | |||
DOCK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05100 | Bacterial invasion of epithelial cells | |
| hsa05131 | Shigellosis |
Expression of DOCK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOCK1 | 1793 | 203187_at | -0.1727 | 0.7040 | |
| GSE20347 | DOCK1 | 1793 | 203187_at | 0.0929 | 0.6154 | |
| GSE23400 | DOCK1 | 1793 | 203187_at | 0.1309 | 0.0036 | |
| GSE26886 | DOCK1 | 1793 | 203187_at | -0.2021 | 0.3635 | |
| GSE29001 | DOCK1 | 1793 | 203187_at | 0.0883 | 0.8135 | |
| GSE38129 | DOCK1 | 1793 | 203187_at | 0.0296 | 0.8389 | |
| GSE45670 | DOCK1 | 1793 | 203187_at | -0.3130 | 0.0099 | |
| GSE53622 | DOCK1 | 1793 | 28375 | 0.1453 | 0.0229 | |
| GSE53624 | DOCK1 | 1793 | 28375 | 0.1307 | 0.1497 | |
| GSE63941 | DOCK1 | 1793 | 203187_at | -1.0777 | 0.0042 | |
| GSE77861 | DOCK1 | 1793 | 203187_at | 0.1460 | 0.4998 | |
| GSE97050 | DOCK1 | 1793 | A_23_P45059 | -0.1382 | 0.6047 | |
| SRP007169 | DOCK1 | 1793 | RNAseq | 1.4380 | 0.0062 | |
| SRP008496 | DOCK1 | 1793 | RNAseq | 1.1118 | 0.0016 | |
| SRP064894 | DOCK1 | 1793 | RNAseq | -0.1832 | 0.4492 | |
| SRP133303 | DOCK1 | 1793 | RNAseq | -0.0284 | 0.8134 | |
| SRP159526 | DOCK1 | 1793 | RNAseq | -0.3967 | 0.1501 | |
| SRP193095 | DOCK1 | 1793 | RNAseq | 0.0158 | 0.8934 | |
| SRP219564 | DOCK1 | 1793 | RNAseq | -0.2687 | 0.3396 | |
| TCGA | DOCK1 | 1793 | RNAseq | -0.0892 | 0.0638 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by DOCK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOCK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOCK1 | 1793 | 2 | 7 | 21 | |
| GSE20123 | DOCK1 | 1793 | 2 | 7 | 21 | |
| GSE43470 | DOCK1 | 1793 | 0 | 10 | 33 | |
| GSE46452 | DOCK1 | 1793 | 0 | 11 | 48 | |
| GSE47630 | DOCK1 | 1793 | 4 | 13 | 23 | |
| GSE54993 | DOCK1 | 1793 | 8 | 1 | 61 | |
| GSE54994 | DOCK1 | 1793 | 1 | 9 | 43 | |
| GSE60625 | DOCK1 | 1793 | 0 | 0 | 11 | |
| GSE74703 | DOCK1 | 1793 | 0 | 6 | 30 | |
| GSE74704 | DOCK1 | 1793 | 2 | 3 | 15 | |
| TCGA | DOCK1 | 1793 | 7 | 29 | 60 |
Total number of gains: 26; Total number of losses: 96; Total Number of normals: 366.
Somatic mutations of DOCK1:
Generating mutation plots.
Highly correlated genes for DOCK1:
Showing top 20/534 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOCK1 | WEE1 | 0.811442 | 3 | 0 | 3 |
| DOCK1 | FBXW4 | 0.789373 | 3 | 0 | 3 |
| DOCK1 | FGFR1OP2 | 0.774951 | 3 | 0 | 3 |
| DOCK1 | C11orf68 | 0.762119 | 3 | 0 | 3 |
| DOCK1 | PODN | 0.75683 | 3 | 0 | 3 |
| DOCK1 | LDLRAP1 | 0.755958 | 3 | 0 | 3 |
| DOCK1 | COQ10A | 0.740133 | 3 | 0 | 3 |
| DOCK1 | P2RY12 | 0.725534 | 3 | 0 | 3 |
| DOCK1 | ADPRH | 0.723447 | 3 | 0 | 3 |
| DOCK1 | ZNF655 | 0.723303 | 3 | 0 | 3 |
| DOCK1 | UNC45A | 0.720776 | 3 | 0 | 3 |
| DOCK1 | ANO5 | 0.718423 | 3 | 0 | 3 |
| DOCK1 | CD99L2 | 0.706443 | 4 | 0 | 4 |
| DOCK1 | GNAQ | 0.705705 | 4 | 0 | 3 |
| DOCK1 | WDR92 | 0.704276 | 3 | 0 | 3 |
| DOCK1 | SPOPL | 0.702115 | 4 | 0 | 4 |
| DOCK1 | CREB3L2 | 0.701204 | 3 | 0 | 3 |
| DOCK1 | KLHDC1 | 0.700324 | 5 | 0 | 5 |
| DOCK1 | SGCA | 0.697188 | 3 | 0 | 3 |
| DOCK1 | CHL1 | 0.691835 | 3 | 0 | 3 |
For details and further investigation, click here
