| Full name: X-ray repair cross complementing 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 7515 | HGNC ID: HGNC:12828 | Ensembl Gene: ENSG00000073050 | OMIM ID: 194360 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of XRCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRCC1 | 7515 | 203655_at | 0.1872 | 0.5397 | |
| GSE20347 | XRCC1 | 7515 | 203655_at | -0.0411 | 0.6814 | |
| GSE23400 | XRCC1 | 7515 | 203655_at | 0.1598 | 0.0032 | |
| GSE26886 | XRCC1 | 7515 | 203655_at | 0.4888 | 0.0225 | |
| GSE29001 | XRCC1 | 7515 | 203655_at | 0.4735 | 0.1994 | |
| GSE38129 | XRCC1 | 7515 | 203655_at | 0.0506 | 0.5249 | |
| GSE45670 | XRCC1 | 7515 | 203655_at | 0.1476 | 0.1032 | |
| GSE53622 | XRCC1 | 7515 | 10317 | 0.3914 | 0.0000 | |
| GSE53624 | XRCC1 | 7515 | 10317 | 0.5286 | 0.0000 | |
| GSE63941 | XRCC1 | 7515 | 203655_at | 0.2229 | 0.4198 | |
| GSE77861 | XRCC1 | 7515 | 203655_at | -0.0628 | 0.8058 | |
| GSE97050 | XRCC1 | 7515 | A_23_P153692 | 0.3106 | 0.2434 | |
| SRP007169 | XRCC1 | 7515 | RNAseq | 0.2893 | 0.4418 | |
| SRP008496 | XRCC1 | 7515 | RNAseq | -0.0221 | 0.9364 | |
| SRP064894 | XRCC1 | 7515 | RNAseq | 0.6647 | 0.0009 | |
| SRP133303 | XRCC1 | 7515 | RNAseq | 0.3526 | 0.0714 | |
| SRP159526 | XRCC1 | 7515 | RNAseq | 0.7092 | 0.0194 | |
| SRP193095 | XRCC1 | 7515 | RNAseq | 0.3999 | 0.0000 | |
| SRP219564 | XRCC1 | 7515 | RNAseq | 0.4595 | 0.0617 | |
| TCGA | XRCC1 | 7515 | RNAseq | 0.0674 | 0.2326 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by XRCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRCC1 | 7515 | 6 | 5 | 19 | |
| GSE20123 | XRCC1 | 7515 | 5 | 4 | 21 | |
| GSE43470 | XRCC1 | 7515 | 4 | 11 | 28 | |
| GSE46452 | XRCC1 | 7515 | 45 | 1 | 13 | |
| GSE47630 | XRCC1 | 7515 | 8 | 6 | 26 | |
| GSE54993 | XRCC1 | 7515 | 17 | 4 | 49 | |
| GSE54994 | XRCC1 | 7515 | 6 | 12 | 35 | |
| GSE60625 | XRCC1 | 7515 | 9 | 0 | 2 | |
| GSE74703 | XRCC1 | 7515 | 4 | 7 | 25 | |
| GSE74704 | XRCC1 | 7515 | 4 | 2 | 14 | |
| TCGA | XRCC1 | 7515 | 14 | 16 | 66 |
Total number of gains: 122; Total number of losses: 68; Total Number of normals: 298.
Somatic mutations of XRCC1:
Generating mutation plots.
Highly correlated genes for XRCC1:
Showing top 20/673 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRCC1 | ZNF121 | 0.805594 | 3 | 0 | 3 |
| XRCC1 | CSTF2T | 0.803957 | 3 | 0 | 3 |
| XRCC1 | ACY1 | 0.788195 | 3 | 0 | 3 |
| XRCC1 | PPP1R37 | 0.766263 | 4 | 0 | 4 |
| XRCC1 | ADCK1 | 0.760218 | 3 | 0 | 3 |
| XRCC1 | LTV1 | 0.759586 | 3 | 0 | 3 |
| XRCC1 | LEMD2 | 0.748805 | 3 | 0 | 3 |
| XRCC1 | PACSIN3 | 0.745525 | 3 | 0 | 3 |
| XRCC1 | HIVEP3 | 0.741492 | 3 | 0 | 3 |
| XRCC1 | SEC16A | 0.740322 | 3 | 0 | 3 |
| XRCC1 | TBC1D28 | 0.739684 | 3 | 0 | 3 |
| XRCC1 | FAM90A1 | 0.737999 | 3 | 0 | 3 |
| XRCC1 | RBM26 | 0.730504 | 3 | 0 | 3 |
| XRCC1 | MAD2L2 | 0.730231 | 3 | 0 | 3 |
| XRCC1 | UNK | 0.726863 | 3 | 0 | 3 |
| XRCC1 | ZNF503 | 0.726764 | 3 | 0 | 3 |
| XRCC1 | UBIAD1 | 0.724403 | 3 | 0 | 3 |
| XRCC1 | FOXP4 | 0.722394 | 3 | 0 | 3 |
| XRCC1 | SGSH | 0.717231 | 3 | 0 | 3 |
| XRCC1 | POLR3C | 0.713948 | 3 | 0 | 3 |
For details and further investigation, click here
