| Full name: Zic family member 1 | Alias Symbol: ZIC|ZNF201 | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 7545 | HGNC ID: HGNC:12872 | Ensembl Gene: ENSG00000152977 | OMIM ID: 600470 |
| Drug and gene relationship at DGIdb | |||
Expression of ZIC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZIC1 | 7545 | 206373_at | 2.2252 | 0.3210 | |
| GSE20347 | ZIC1 | 7545 | 206373_at | 2.9505 | 0.0000 | |
| GSE23400 | ZIC1 | 7545 | 206373_at | 0.8345 | 0.0000 | |
| GSE26886 | ZIC1 | 7545 | 234716_at | 0.5562 | 0.0009 | |
| GSE29001 | ZIC1 | 7545 | 206373_at | 2.3927 | 0.0135 | |
| GSE38129 | ZIC1 | 7545 | 206373_at | 2.7220 | 0.0000 | |
| GSE45670 | ZIC1 | 7545 | 206373_at | 2.1642 | 0.0235 | |
| GSE53622 | ZIC1 | 7545 | 116929 | 1.0542 | 0.0000 | |
| GSE53624 | ZIC1 | 7545 | 116929 | 1.3972 | 0.0000 | |
| GSE63941 | ZIC1 | 7545 | 206373_at | 2.6490 | 0.2325 | |
| GSE77861 | ZIC1 | 7545 | 234716_at | -0.1279 | 0.4921 | |
| GSE97050 | ZIC1 | 7545 | A_33_P3219578 | 0.3104 | 0.2481 | |
| SRP159526 | ZIC1 | 7545 | RNAseq | 6.7962 | 0.0000 | |
| TCGA | ZIC1 | 7545 | RNAseq | 2.4872 | 0.0017 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by ZIC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZIC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZIC1 | 7545 | 22 | 0 | 8 | |
| GSE20123 | ZIC1 | 7545 | 22 | 0 | 8 | |
| GSE43470 | ZIC1 | 7545 | 23 | 0 | 20 | |
| GSE46452 | ZIC1 | 7545 | 16 | 3 | 40 | |
| GSE47630 | ZIC1 | 7545 | 19 | 3 | 18 | |
| GSE54993 | ZIC1 | 7545 | 1 | 9 | 60 | |
| GSE54994 | ZIC1 | 7545 | 34 | 1 | 18 | |
| GSE60625 | ZIC1 | 7545 | 0 | 6 | 5 | |
| GSE74703 | ZIC1 | 7545 | 20 | 0 | 16 | |
| GSE74704 | ZIC1 | 7545 | 15 | 0 | 5 | |
| TCGA | ZIC1 | 7545 | 68 | 2 | 26 |
Total number of gains: 240; Total number of losses: 24; Total Number of normals: 224.
Somatic mutations of ZIC1:
Generating mutation plots.
Highly correlated genes for ZIC1:
Showing top 20/301 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZIC1 | MGAT5B | 0.794631 | 3 | 0 | 3 |
| ZIC1 | SCARF2 | 0.77752 | 3 | 0 | 3 |
| ZIC1 | ARMC5 | 0.774297 | 3 | 0 | 3 |
| ZIC1 | CCDC114 | 0.767728 | 3 | 0 | 3 |
| ZIC1 | TSPAN10 | 0.764268 | 3 | 0 | 3 |
| ZIC1 | KLK14 | 0.754517 | 3 | 0 | 3 |
| ZIC1 | IQSEC3 | 0.751332 | 3 | 0 | 3 |
| ZIC1 | PHGR1 | 0.739118 | 3 | 0 | 3 |
| ZIC1 | CEMP1 | 0.733724 | 3 | 0 | 3 |
| ZIC1 | ZNF687 | 0.730827 | 3 | 0 | 3 |
| ZIC1 | CPNE9 | 0.730406 | 3 | 0 | 3 |
| ZIC1 | UPK3A | 0.728515 | 3 | 0 | 3 |
| ZIC1 | SP8 | 0.727486 | 3 | 0 | 3 |
| ZIC1 | PPP1R3F | 0.724598 | 3 | 0 | 3 |
| ZIC1 | CLSTN3 | 0.722282 | 3 | 0 | 3 |
| ZIC1 | ARMC7 | 0.722209 | 3 | 0 | 3 |
| ZIC1 | NCR3 | 0.719871 | 3 | 0 | 3 |
| ZIC1 | DNAJB8 | 0.719815 | 3 | 0 | 3 |
| ZIC1 | FAM181B | 0.717903 | 3 | 0 | 3 |
| ZIC1 | CEBPE | 0.714976 | 4 | 0 | 3 |
For details and further investigation, click here
