| Full name: IQ motif and Sec7 domain 3 | Alias Symbol: KIAA1110|MGC30156 | ||
| Type: protein-coding gene | Cytoband: 12p13.33 | ||
| Entrez ID: 440073 | HGNC ID: HGNC:29193 | Ensembl Gene: ENSG00000120645 | OMIM ID: 612118 |
| Drug and gene relationship at DGIdb | |||
Expression of IQSEC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IQSEC3 | 440073 | 213834_at | 0.0463 | 0.8756 | |
| GSE20347 | IQSEC3 | 440073 | 213834_at | 0.0006 | 0.9961 | |
| GSE23400 | IQSEC3 | 440073 | 213834_at | -0.0655 | 0.0337 | |
| GSE26886 | IQSEC3 | 440073 | 1556872_s_at | 0.4066 | 0.0026 | |
| GSE29001 | IQSEC3 | 440073 | 213834_at | -0.0847 | 0.6860 | |
| GSE38129 | IQSEC3 | 440073 | 213834_at | -0.1170 | 0.1518 | |
| GSE45670 | IQSEC3 | 440073 | 1556872_s_at | -0.0140 | 0.8915 | |
| GSE53622 | IQSEC3 | 440073 | 12842 | -0.0116 | 0.9454 | |
| GSE53624 | IQSEC3 | 440073 | 12842 | 0.3046 | 0.0144 | |
| GSE63941 | IQSEC3 | 440073 | 1553949_at | -0.2184 | 0.1371 | |
| GSE77861 | IQSEC3 | 440073 | 213834_at | -0.0833 | 0.6523 | |
| GSE97050 | IQSEC3 | 440073 | A_33_P3209581 | 0.1087 | 0.6669 | |
| SRP064894 | IQSEC3 | 440073 | RNAseq | 1.0021 | 0.0021 | |
| SRP133303 | IQSEC3 | 440073 | RNAseq | -0.0637 | 0.8707 | |
| SRP159526 | IQSEC3 | 440073 | RNAseq | -0.2944 | 0.6293 | |
| SRP219564 | IQSEC3 | 440073 | RNAseq | 1.4343 | 0.0059 | |
| TCGA | IQSEC3 | 440073 | RNAseq | -1.0729 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by IQSEC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IQSEC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IQSEC3 | 440073 | 7 | 4 | 19 | |
| GSE20123 | IQSEC3 | 440073 | 7 | 4 | 19 | |
| GSE43470 | IQSEC3 | 440073 | 9 | 3 | 31 | |
| GSE46452 | IQSEC3 | 440073 | 10 | 1 | 48 | |
| GSE47630 | IQSEC3 | 440073 | 12 | 2 | 26 | |
| GSE54993 | IQSEC3 | 440073 | 1 | 10 | 59 | |
| GSE54994 | IQSEC3 | 440073 | 10 | 2 | 41 | |
| GSE60625 | IQSEC3 | 440073 | 0 | 1 | 10 | |
| GSE74703 | IQSEC3 | 440073 | 8 | 2 | 26 | |
| GSE74704 | IQSEC3 | 440073 | 4 | 2 | 14 | |
| TCGA | IQSEC3 | 440073 | 41 | 7 | 48 |
Total number of gains: 109; Total number of losses: 38; Total Number of normals: 341.
Somatic mutations of IQSEC3:
Generating mutation plots.
Highly correlated genes for IQSEC3:
Showing top 20/609 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IQSEC3 | DPEP3 | 0.771635 | 4 | 0 | 3 |
| IQSEC3 | PGK2 | 0.763821 | 3 | 0 | 3 |
| IQSEC3 | NXF5 | 0.754435 | 3 | 0 | 3 |
| IQSEC3 | ZIC1 | 0.751332 | 3 | 0 | 3 |
| IQSEC3 | ISLR2 | 0.750968 | 4 | 0 | 4 |
| IQSEC3 | EBF4 | 0.720393 | 3 | 0 | 3 |
| IQSEC3 | GNL1 | 0.719783 | 4 | 0 | 3 |
| IQSEC3 | USHBP1 | 0.713489 | 3 | 0 | 3 |
| IQSEC3 | CDRT15 | 0.712548 | 4 | 0 | 4 |
| IQSEC3 | PHGR1 | 0.712144 | 3 | 0 | 3 |
| IQSEC3 | TULP1 | 0.708237 | 4 | 0 | 4 |
| IQSEC3 | CNTD2 | 0.706446 | 5 | 0 | 5 |
| IQSEC3 | LCT | 0.705994 | 5 | 0 | 5 |
| IQSEC3 | AQP6 | 0.695854 | 6 | 0 | 6 |
| IQSEC3 | BEND4 | 0.693238 | 3 | 0 | 3 |
| IQSEC3 | LMAN1L | 0.692595 | 6 | 0 | 6 |
| IQSEC3 | TSPAN32 | 0.690566 | 6 | 0 | 6 |
| IQSEC3 | TSPO2 | 0.690265 | 5 | 0 | 5 |
| IQSEC3 | RALYL | 0.689229 | 4 | 0 | 4 |
| IQSEC3 | PHF1 | 0.688726 | 3 | 0 | 3 |
For details and further investigation, click here
